ENSDARG00000018742


Danio rerio

Features
Gene ID: ENSDARG00000018742
  
Biological name :psme4b
  
Synonyms : proteasome activator subunit 4b / psme4b
  
Possible biological names infered from orthology : Proteasome activator complex subunit 4 / proteasome activator subunit 4 / PSME4 / Q14997 / Q5SSW2
  
Species: Danio rerio
  
Chr. number: 12
Strand: 1
Band:
Gene start: 23991276
Gene end: 24053079
  
Corresponding Affymetrix probe sets: Dr.11168.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000015440
Ensembl peptide - ENSDARP00000127351
NCBI entrez gene - 553346     See in Manteia.
RefSeq - NM_001191020
RefSeq - XM_005156206
RefSeq Peptide - NP_001177949
swissprot - T1ECT6
swissprot - F1QE31
ZFIN ID - ZDB-GENE-100316-4
Ensembl - ENSDARG00000018742
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PSME4ENSGALG00000008163Gallus gallus
 PSME4ENSG00000068878Homo sapiens
 Psme4ENSMUSG00000040850Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
psme4b / psme4a / proteasome activator subunit 4a / PSME4* / Q14997* / Q5SSW2* / proteasome activator subunit 4* / Proteasome activator complex subunit 4 *ENSDARG0000008791178


Protein motifs (from Interpro)
Interpro ID Name
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR021843  Proteasome activator complex subunit 4 C-terminal domain
 IPR032430  Proteasome activator Blm10, mid region
 IPR035309  Proteasome activator complex subunit 4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010952 positive regulation of peptidase activity IEA
 molecular_functionGO:0016504 peptidase activator activity IEA
 molecular_functionGO:0070577 lysine-acetylated histone binding IEA
 molecular_functionGO:0070628 proteasome binding IEA


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Cross-presentation of soluble exogenous antigens (endosomes)
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
Ubiquitin-dependent degradation of Cyclin D1
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of PTEN stability and activity
Neddylation
Interleukin-1 signaling
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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