ENSDARG00000087911


Danio rerio

Features
Gene ID: ENSDARG00000087911
  
Biological name :psme4a
  
Synonyms : proteasome activator subunit 4a / psme4a / psme4b
  
Possible biological names infered from orthology : Proteasome activator complex subunit 4 / proteasome activator subunit 4 / PSME4 / Q14997 / Q5SSW2
  
Species: Danio rerio
  
Chr. number: 13
Strand: 1
Band:
Gene start: 35689749
Gene end: 35744963
  
Corresponding Affymetrix probe sets: Dr.7842.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000107489
Ensembl peptide - ENSDARP00000131347
Ensembl peptide - ENSDARP00000107560
NCBI entrez gene - 793897     See in Manteia.
RefSeq - XM_009307491
swissprot - A0A0R4IAF6
swissprot - A0A0A0MPN8
swissprot - T1ECT6
ZFIN ID - ZDB-GENE-091204-452
ZFIN ID - ZDB-GENE-100316-4
Ensembl - ENSDARG00000087911
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PSME4ENSGALG00000008163Gallus gallus
 PSME4ENSG00000068878Homo sapiens
 Psme4ENSMUSG00000040850Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
psme4b / proteasome activator subunit 4b / PSME4* / Q14997* / Q5SSW2* / proteasome activator subunit 4* / Proteasome activator complex subunit 4 *ENSDARG0000001874276


Protein motifs (from Interpro)
Interpro ID Name
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR021843  Proteasome activator complex subunit 4 C-terminal domain
 IPR032430  Proteasome activator Blm10, mid region
 IPR035309  Proteasome activator complex subunit 4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010499 proteasomal ubiquitin-independent protein catabolic process IBA
 biological_processGO:0010952 positive regulation of peptidase activity IEA
 biological_processGO:0035093 spermatogenesis, exchange of chromosomal proteins IBA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005829 cytosol IBA
 cellular_componentGO:0005839 proteasome core complex IBA
 cellular_componentGO:1990111 spermatoproteasome complex IBA
 molecular_functionGO:0016504 peptidase activator activity IBA
 molecular_functionGO:0070577 lysine-acetylated histone binding IBA
 molecular_functionGO:0070628 proteasome binding IBA


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Cross-presentation of soluble exogenous antigens (endosomes)
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
Ubiquitin-dependent degradation of Cyclin D1
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of PTEN stability and activity
Neddylation
Interleukin-1 signaling
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr