ENSGALG00000008163


Gallus gallus

Features
Gene ID: ENSGALG00000008163
  
Biological name :PSME4
  
Synonyms : proteasome activator subunit 4 / PSME4
  
Possible biological names infered from orthology : Proteasome activator complex subunit 4 / Q14997 / Q5SSW2
  
Species: Gallus gallus
  
Chr. number: 3
Strand: 1
Band:
Gene start: 2947673
Gene end: 3011366
  
Corresponding Affymetrix probe sets: Gga.5829.1.S1_at (Chicken Array)   GgaAffx.11962.1.S1_at (Chicken Array)   GgaAffx.11962.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000013250
Ensembl peptide - ENSGALP00000040718
NCBI entrez gene - 421218     See in Manteia.
RefSeq - XM_015283354
RefSeq - NM_001006393
RefSeq Peptide - NP_001006393
swissprot - R4GFD0
swissprot - F1ND07
Ensembl - ENSGALG00000008163
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 psme4aENSDARG00000087911Danio rerio
 psme4bENSDARG00000018742Danio rerio
 PSME4ENSG00000068878Homo sapiens
 Psme4ENSMUSG00000040850Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR021843  Proteasome activator complex subunit 4 C-terminal domain
 IPR032430  Proteasome activator Blm10, mid region


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0010499 proteasomal ubiquitin-independent protein catabolic process IBA
 biological_processGO:0010952 positive regulation of peptidase activity IEA
 biological_processGO:0035093 spermatogenesis, exchange of chromosomal proteins IBA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005829 cytosol IBA
 cellular_componentGO:0005839 proteasome core complex IBA
 cellular_componentGO:1990111 spermatoproteasome complex IBA
 molecular_functionGO:0016504 peptidase activator activity IBA
 molecular_functionGO:0070577 lysine-acetylated histone binding IBA
 molecular_functionGO:0070628 proteasome binding IBA


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells
Cross-presentation of soluble exogenous antigens (endosomes)
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog on state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
Ubiquitin-dependent degradation of Cyclin D1
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of PTEN stability and activity
Neddylation
Interleukin-1 signaling
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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