ENSMUSG00000040850


Mus musculus

Features
Gene ID: ENSMUSG00000040850
  
Biological name :Psme4
  
Synonyms : Proteasome activator complex subunit 4 / Psme4 / Q5SSW2
  
Possible biological names infered from orthology : proteasome activator subunit 4 / Q14997
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: A4
Gene start: 30771726
Gene end: 30880361
  
Corresponding Affymetrix probe sets: 10374934 (MoGene1.0st)   1426823_s_at (Mouse Genome 430 2.0 Array)   1426824_at (Mouse Genome 430 2.0 Array)   1443116_at (Mouse Genome 430 2.0 Array)   1445147_at (Mouse Genome 430 2.0 Array)   1446464_at (Mouse Genome 430 2.0 Array)   1452211_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000045460
Ensembl peptide - ENSMUSP00000114537
Ensembl peptide - ENSMUSP00000119133
NCBI entrez gene - 103554     See in Manteia.
MGI - MGI:2143994
RefSeq - XM_017314207
RefSeq - NM_134013
RefSeq - XM_011243649
RefSeq Peptide - NP_598774
swissprot - Q5SSW0
swissprot - Q5SSW2
swissprot - F6R7K9
Ensembl - ENSMUSG00000040850
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 psme4aENSDARG00000087911Danio rerio
 psme4bENSDARG00000018742Danio rerio
 PSME4ENSGALG00000008163Gallus gallus
 PSME4ENSG00000068878Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR021843  Proteasome activator complex subunit 4 C-terminal domain
 IPR032430  Proteasome activator Blm10, mid region
 IPR035309  Proteasome activator complex subunit 4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IMP
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0010499 proteasomal ubiquitin-independent protein catabolic process IDA
 biological_processGO:0010952 positive regulation of peptidase activity IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0035093 spermatogenesis, exchange of chromosomal proteins IMP
 cellular_componentGO:0000502 proteasome complex IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005839 proteasome core complex IBA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:1990111 spermatoproteasome complex IDA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0016504 peptidase activator activity IEA
 molecular_functionGO:0070577 lysine-acetylated histone binding IEA
 molecular_functionGO:0070628 proteasome binding IEA


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Cross-presentation of soluble exogenous antigens (endosomes)
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog on state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
Ubiquitin-dependent degradation of Cyclin D1
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of PTEN stability and activity
Neddylation
Interleukin-1 signaling
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
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Allelic Composition: Adora2atm1Dyj/Adora2atm1Dyj,Tg(Camk2a-cre)1Szi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Adora2atm1Dyj/Adora2atm1Dyj,Tg(Camk2a-cre)1Szi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Psme4tm1Tchi/Psme4tm1Tchi
Genetic Background: involves: C57BL/6

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Adora2atm1Dyj/Adora2atm1Dyj,Tg(Camk2a-cre)1Szi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0005578 teratozoospermia "presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
Show

Allelic Composition: Adora2atm1Dyj/Adora2atm1Dyj,Tg(Camk2a-cre)1Szi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0006362 abnormal male germ cell morphology "any structural anomaly of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adora2atm1Dyj/Adora2atm1Dyj,Tg(Camk2a-cre)1Szi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0006379 abnormal spermatocyte morphology "anomaly in the number or structure of male germ cells that through meiosis give rise to spermatids " [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adora2atm1Dyj/Adora2atm1Dyj,Tg(Camk2a-cre)1Szi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adora2atm1Dyj/Adora2atm1Dyj,Tg(Camk2a-cre)1Szi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Psme4tm1Tchi/Psme4tm1Tchi
Genetic Background: involves: C57BL/6

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Psme4tm1Tchi/Psme4tm1Tchi
Genetic Background: involves: C57BL/6

 MP:0020550 multinucleated giant male germ cells "presence of large cells containing multiple nuclei formed abnormal opening of the cytoplasmic bridges that are part of normal germ cell division" [PMID:16272280, url:https://ntp.niehs.nih.gov/nnl/male_reproductive/testis/setubmgcel/index.htm]
Show

Allelic Composition: Adora2atm1Dyj/Adora2atm1Dyj,Tg(Camk2a-cre)1Szi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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