ENSDARG00000019000


Danio rerio

Features
Gene ID: ENSDARG00000019000
  
Biological name :smc3
  
Synonyms : smc3 / structural maintenance of chromosomes 3
  
Possible biological names infered from orthology : Q9CW03 / Q9UQE7 / Structural maintenance of chromosomes protein 3
  
Species: Danio rerio
  
Chr. number: 22
Strand: -1
Band:
Gene start: 29858535
Gene end: 29906764
  
Corresponding Affymetrix probe sets: Dr.24937.1.S1_at (Zebrafish Array)   NM_214689_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000024411
NCBI entrez gene - 324475     See in Manteia.
RefSeq - NM_214689
RefSeq Peptide - NP_999854
swissprot - Q1LVV8
ZFIN ID - ZDB-GENE-030131-3196
Ensembl - ENSDARG00000019000
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SMC3ENSGALG00000008585Gallus gallus
 SMC3ENSG00000108055Homo sapiens
 Smc3ENSMUSG00000024974Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003395  RecF/RecN/SMC, N-terminal
 IPR010935  SMCs flexible hinge
 IPR024704  Structural maintenance of chromosomes protein
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007064 mitotic sister chromatid cohesion IMP
 biological_processGO:0051276 chromosome organization IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005694 chromosome IEA
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
Separation of Sister Chromatids
Establishment of Sister Chromatid Cohesion
Cohesin Loading onto Chromatin
Resolution of Sister Chromatid Cohesion
SUMOylation of DNA damage response and repair proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain necrotic , abnormal
Show

 ZFA:0000100 cerebellum cerebellum necrotic , abnormal
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 ZFA:0000107 eye eye necrotic , abnormal
eye decreased size , abnormal
eye decreased size , ameliorated
Show

 ZFA:0000114 heart heart edematous , abnormal
Show

 ZFA:0000135 notochord notochord morphology , abnormal
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 ZFA:0000155 somite somite structure , abnormal
Show

 ZFA:0001058 caudal fin caudal fin aplastic , abnormal
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 ZFA:0001094 whole organism whole organism decreased length , abnormal
whole organism ploidy , abnormal
whole organism morphology , abnormal
whole organism deformed , abnormal
whole organism increased amount , abnormal
whole organism lethal (sensu genetics) , abnormal
whole organism lethal (sensu genetics) , ameliorated
Show

 ZFA:0001114 head head decreased size , abnormal
head decreased size , ameliorated
head apoptotic process increased occurrence , abnormal
head apoptotic process increased occurrence , ameliorated
Show

 ZFA:0001115 trunk trunk decreased length , ameliorated
Show

 ZFA:0001117 post-vent region post-vent region morphology , abnormal
post-vent region curved , abnormal
post-vent region curved , ameliorated
post-vent region apoptotic process increased occurrence , abnormal
post-vent region apoptotic process increased occurrence , ameliorated
Show

 ZFA:0001458 cranial cartilage cranial cartilage cartilage development disrupted , abnormal
cranial cartilage cartilage development decreased process quality , ameliorated
Show

 ZFA:0009000 cell cell spindle morphology , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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