ENSMUSG00000024974


Mus musculus

Features
Gene ID: ENSMUSG00000024974
  
Biological name :Smc3
  
Synonyms : Q9CW03 / Smc3 / Structural maintenance of chromosomes protein 3
  
Possible biological names infered from orthology : Q9UQE7 / structural maintenance of chromosomes 3
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: D2
Gene start: 53600398
Gene end: 53645833
  
Corresponding Affymetrix probe sets: 10463951 (MoGene1.0st)   1450950_at (Mouse Genome 430 2.0 Array)   1450951_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025930
NCBI entrez gene - 13006     See in Manteia.
MGI - MGI:1339795
RefSeq - NM_007790
RefSeq Peptide - NP_031816
swissprot - Q1HL32
swissprot - Q9CW03
Ensembl - ENSMUSG00000024974
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 smc3ENSDARG00000019000Danio rerio
 SMC3ENSGALG00000008585Gallus gallus
 SMC3ENSG00000108055Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003395  RecF/RecN/SMC, N-terminal
 IPR010935  SMCs flexible hinge
 IPR024704  Structural maintenance of chromosomes protein
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR036277  SMCs flexible hinge superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006275 regulation of DNA replication IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007062 sister chromatid cohesion IEA
 biological_processGO:0019827 stem cell population maintenance IMP
 biological_processGO:0032876 negative regulation of DNA endoreduplication IEA
 biological_processGO:0044791 positive regulation by host of viral release from host cell IEA
 biological_processGO:0051276 chromosome organization IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051321 meiotic cell cycle ISO
 biological_processGO:0051702 interaction with symbiont IEA
 biological_processGO:1901673 regulation of mitotic spindle assembly IEA
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000785 chromatin IEA
 cellular_componentGO:0000800 lateral element IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0008278 cohesin complex IDA
 cellular_componentGO:0016363 nuclear matrix IEA
 cellular_componentGO:0030893 meiotic cohesin complex IEA
 cellular_componentGO:0034991 nuclear meiotic cohesin complex IDA
 cellular_componentGO:0097431 mitotic spindle pole IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0036033 mediator complex binding IDA
 molecular_functionGO:0044877 protein-containing complex binding IDA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0048487 beta-tubulin binding IEA
 molecular_functionGO:0070840 dynein complex binding IEA


Pathways (from Reactome)
Pathway description
Separation of Sister Chromatids
Establishment of Sister Chromatid Cohesion
Cohesin Loading onto Chromatin
Resolution of Sister Chromatid Cohesion
SUMOylation of DNA damage response and repair proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Braftm1Mmcm/Braftm1Mmcm,Nkx3-1tm4(cre/ERT2)Mms/Nkx3-1+,Ptentm1Hwu/Pten+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Braftm1Mmcm/Braftm1Mmcm,Nkx3-1tm4(cre/ERT2)Mms/Nkx3-1+,Ptentm1Hwu/Pten+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Smc3tm1a(EUCOMM)Wtsi/Smc3+
Genetic Background: B6Dnk;B6Brd;B6N-Tyrc-Brd Smc3tm1a(EUCOMM)Wtsi/WtsiH

 MP:0002075 abnormal coat color "irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slx4tm1a(EUCOMM)Wtsi/Slx4tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Slx4tm1a(EUCOMM)Wtsi/Wtsi

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Smc3tm1a(EUCOMM)Wtsi/Smc3+
Genetic Background: B6Dnk;B6Brd;B6N-Tyrc-Brd Smc3tm1a(EUCOMM)Wtsi/WtsiH

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Braftm1Mmcm/Braftm1Mmcm,Nkx3-1tm4(cre/ERT2)Mms/Nkx3-1+,Ptentm1Hwu/Pten+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0005562 decreased mean corpuscular hemoglobin "less than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Smc3tm1a(EUCOMM)Wtsi/Smc3+
Genetic Background: B6Dnk;B6Brd;B6N-Tyrc-Brd Smc3tm1a(EUCOMM)Wtsi/WtsiH

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Smc3tm1a(EUCOMM)Wtsi/Smc3+
Genetic Background: B6Dnk;B6Brd;B6N-Tyrc-Brd Smc3tm1a(EUCOMM)Wtsi/WtsiH

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Smc3tm1a(EUCOMM)Wtsi/Smc3+
Genetic Background: B6Dnk;B6Brd;B6N-Tyrc-Brd Smc3tm1a(EUCOMM)Wtsi/WtsiH

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Braftm1Mmcm/Braftm1Mmcm,Nkx3-1tm4(cre/ERT2)Mms/Nkx3-1+,Ptentm1Hwu/Pten+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Braftm1Mmcm/Braftm1Mmcm,Nkx3-1tm4(cre/ERT2)Mms/Nkx3-1+,Ptentm1Hwu/Pten+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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