ENSDARG00000019507


Danio rerio

Features
Gene ID: ENSDARG00000019507
  
Biological name :mcm5
  
Synonyms : mcm5 / minichromosome maintenance complex component 5
  
Possible biological names infered from orthology : P33992
  
Species: Danio rerio
  
Chr. number: 3
Strand: 1
Band:
Gene start: 25999477
Gene end: 26011440
  
Corresponding Affymetrix probe sets: Dr.11651.1.S1_at (Zebrafish Array)   NM_178436_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000018877
NCBI entrez gene - 286747     See in Manteia.
RefSeq - NM_178436
RefSeq Peptide - NP_848523
swissprot - F1QK71
ZFIN ID - ZDB-GENE-021209-1
Ensembl - ENSDARG00000019507
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MCM5ENSGALG00000012546Gallus gallus
 MCM5ENSG00000100297Homo sapiens
 Mcm5ENSMUSG00000005410Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001208  MCM domain
 IPR008048  DNA replication licensing factor Mcm5
 IPR012340  Nucleic acid-binding, OB-fold
 IPR018525  Mini-chromosome maintenance, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR027925  MCM N-terminal domain
 IPR031327  Mini-chromosome maintenance protein
 IPR033762  MCM OB domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000278 mitotic cell cycle IMP
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006270 DNA replication initiation IEA
 biological_processGO:0032508 DNA duplex unwinding IEA
 biological_processGO:0043009 chordate embryonic development IMP
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0042555 MCM complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003678 DNA helicase activity IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003688 DNA replication origin binding IEA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Activation of ATR in response to replication stress
Assembly of the pre-replicative complex
Orc1 removal from chromatin
Activation of the pre-replicative complex
Switching of origins to a post-replicative state


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000095 pharyngeal arch 3-7 skeleton pharyngeal arch 3-7 skeleton quality , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
Show

 ZFA:0000117 hypoblast hypoblast apoptotic , abnormal
Show

 ZFA:0001094 whole organism whole organism dwarf-like , abnormal
whole organism anatomical surface decreased area , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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