ENSMUSG00000005410


Mus musculus

Features
Gene ID: ENSMUSG00000005410
  
Biological name :Mcm5
  
Synonyms : Mcm5 / minichromosome maintenance complex component 5
  
Possible biological names infered from orthology : P33992
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: C1
Gene start: 75109569
Gene end: 75128439
  
Corresponding Affymetrix probe sets: 10572906 (MoGene1.0st)   1415945_at (Mouse Genome 430 2.0 Array)   1436808_x_at (Mouse Genome 430 2.0 Array)   1459658_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000126135
Ensembl peptide - ENSMUSP00000148525
Ensembl peptide - ENSMUSP00000148648
NCBI entrez gene - 17218     See in Manteia.
MGI - MGI:103197
RefSeq - NM_001302540
RefSeq - NM_008566
RefSeq Peptide - NP_001289469
RefSeq Peptide - NP_032592
swissprot - Q52KC3
Ensembl - ENSMUSG00000005410
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mcm5ENSDARG00000019507Danio rerio
 MCM5ENSGALG00000012546Gallus gallus
 MCM5ENSG00000100297Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001208  MCM domain
 IPR008048  DNA replication licensing factor Mcm5
 IPR012340  Nucleic acid-binding, OB-fold
 IPR018525  Mini-chromosome maintenance, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR027925  MCM N-terminal domain
 IPR031327  Mini-chromosome maintenance protein
 IPR033762  MCM OB domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006270 DNA replication initiation IEA
 biological_processGO:0032508 DNA duplex unwinding IEA
 biological_processGO:0051301 cell division IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0042555 MCM complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003678 DNA helicase activity IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003688 DNA replication origin binding IEA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Activation of ATR in response to replication stress
Assembly of the pre-replicative complex
Orc1 removal from chromatin
Activation of the pre-replicative complex
Switching of origins to a post-replicative state


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0008762 embryonic lethality "death of an animal in the embryonic period (Mus: up to E14)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Klm1Anu/Klm1Anu
Genetic Background: C57BL/6NCrlAnu-Klm1Anu

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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