ENSG00000100297


Homo sapiens

Features
Gene ID: ENSG00000100297
  
Biological name :MCM5
  
Synonyms : MCM5 / minichromosome maintenance complex component 5 / P33992
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 22
Strand: 1
Band: q12.3
Gene start: 35400063
Gene end: 35425430
  
Corresponding Affymetrix probe sets: 201755_at (Human Genome U133 Plus 2.0 Array)   216237_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000216122
Ensembl peptide - ENSP00000412847
Ensembl peptide - ENSP00000408705
Ensembl peptide - ENSP00000393977
Ensembl peptide - ENSP00000371441
NCBI entrez gene - 4174     See in Manteia.
OMIM - 602696
RefSeq - NM_006739
RefSeq - XM_006724242
RefSeq Peptide - NP_006730
swissprot - B1AHB2
swissprot - P33992
swissprot - F8WFD7
swissprot - B1AHB1
swissprot - B1AHB0
swissprot - B1AHA9
Ensembl - ENSG00000100297
  
Related genetic diseases (OMIM): 617564 - ?Meier-Gorlin syndrome 8, 617564
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mcm5ENSDARG00000019507Danio rerio
 MCM5ENSGALG00000012546Gallus gallus
 Mcm5ENSMUSG00000005410Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001208  MCM domain
 IPR008048  DNA replication licensing factor Mcm5
 IPR012340  Nucleic acid-binding, OB-fold
 IPR018525  Mini-chromosome maintenance, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR027925  MCM N-terminal domain
 IPR031327  Mini-chromosome maintenance protein
 IPR033762  MCM OB domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle TAS
 biological_processGO:0006260 DNA replication TAS
 biological_processGO:0006270 DNA replication initiation IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0032508 DNA duplex unwinding IEA
 biological_processGO:0051301 cell division IEA
 cellular_componentGO:0000784 nuclear chromosome, telomeric region HDA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0042555 MCM complex IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003678 DNA helicase activity IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003688 DNA replication origin binding IEA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Activation of ATR in response to replication stress
Unwinding of DNA
Assembly of the pre-replicative complex
Orc1 removal from chromatin
Activation of the pre-replicative complex
Switching of origins to a post-replicative state


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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