ENSDARG00000019838


Danio rerio

Features
Gene ID: ENSDARG00000019838
  
Biological name :ugdh
  
Synonyms : UDP-glucose 6-dehydrogenase / ugdh
  
Possible biological names infered from orthology : O60701 / O70475 / UDP-glucose dehydrogenase
  
Species: Danio rerio
  
Chr. number: 1
Strand: -1
Band:
Gene start: 23283532
Gene end: 23294753
  
Corresponding Affymetrix probe sets: Dr.14669.1.S1_a_at (Zebrafish Array)   Dr.14669.2.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000004687
Ensembl peptide - ENSDARP00000108630
NCBI entrez gene - 116991     See in Manteia.
swissprot - A8WGP7
ZFIN ID - ZDB-GENE-011022-1
Ensembl - ENSDARG00000019838
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 UGDHENSGALG00000041993Gallus gallus
 UGDHENSG00000109814Homo sapiens
 UgdhENSMUSG00000029201Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001732  UDP-glucose/GDP-mannose dehydrogenase, N-terminal
 IPR008927  6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily
 IPR014026  UDP-glucose/GDP-mannose dehydrogenase, dimerisation
 IPR014027  UDP-glucose/GDP-mannose dehydrogenase, C-terminal
 IPR016040  NAD(P)-binding domain
 IPR017476  UDP-glucose/GDP-mannose dehydrogenase
 IPR028356  UDP-glucose 6-dehydrogenase, eukaryotic type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003188 heart valve formation IMP
 biological_processGO:0003190 atrioventricular valve formation IMP
 biological_processGO:0006024 glycosaminoglycan biosynthetic process IBA
 biological_processGO:0007368 determination of left/right symmetry IMP
 biological_processGO:0007507 heart development IMP
 biological_processGO:0045880 positive regulation of smoothened signaling pathway IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IMP
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005829 cytosol IBA
 molecular_functionGO:0003979 UDP-glucose 6-dehydrogenase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
 molecular_functionGO:0051287 NAD binding IEA


Pathways (from Reactome)
Pathway description
Formation of the active cofactor, UDP-glucuronate


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000001 Kupffer s vesicle Kupffers vesicle increased diameter , abnormal
Kupffers vesicle calcium-mediated signaling process quality , abnormal
Show

 ZFA:0000007 blood blood accumulation cardiac ventricle , abnormal
blood accumulation atrium , abnormal
Show

 ZFA:0000009 cardiac ventricle cardiac ventricle morphology , abnormal
cardiac ventricle shape , abnormal
Show

 ZFA:0000012 central nervous system central nervous system morphology , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000095 pharyngeal arch 3-7 skeleton pharyngeal arch 3-7 skeleton quality , abnormal
Show

 ZFA:0000114 heart heart malformed , abnormal
heart quality , abnormal
heart edematous , abnormal
heart increased size , abnormal
heart lacks all parts of type atrioventricular valve , abnormal
Show

 ZFA:0000431 semicircular canal semicircular canal aplastic , abnormal
Show

 ZFA:0000471 atrium atrium shape , abnormal
Show

 ZFA:0001058 caudal fin caudal fin decreased size , abnormal
Show

 ZFA:0001094 whole organism whole organism decreased length , abnormal
whole organism increased width , abnormal
Show

 ZFA:0001114 head head decreased length , abnormal
Show

 ZFA:0001161 pectoral fin pectoral fin decreased length , abnormal
pectoral fin kinked , abnormal
Show

 ZFA:0001306 pharyngeal arch pharyngeal arch morphology , abnormal
Show

 ZFA:0001460 pharyngeal arch cartilage pharyngeal arch cartilage decreased size , abnormal
pharyngeal arch cartilage condensed , abnormal
Show

 ZFA:0001606 pharyngeal arch 3 pharyngeal arch 3 increased diameter , abnormal
Show

 ZFA:0001613 pharyngeal arch 3-7 pharyngeal arch 3-7 orientation whole organism anterior-posterior axis, abnormal
Show

 ZFA:0005064 atrioventricular valve atrioventricular valve aplastic , abnormal
atrioventricular valve morphology , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000019838 ugdh / UDP-glucose 6-dehydrogenase / O60701* / O70475* / UDP-glucose dehydrogenase*  / complex






 

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