ENSMUSG00000029201


Mus musculus

Features
Gene ID: ENSMUSG00000029201
  
Biological name :Ugdh
  
Synonyms : O70475 / UDP-glucose dehydrogenase / Ugdh
  
Possible biological names infered from orthology : O60701 / UDP-glucose 6-dehydrogenase
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: C3.1
Gene start: 65413221
Gene end: 65435949
  
Corresponding Affymetrix probe sets: 10530201 (MoGene1.0st)   1416308_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000031103
Ensembl peptide - ENSMUSP00000118999
NCBI entrez gene - 22235     See in Manteia.
MGI - MGI:1306785
RefSeq - XM_006503862
RefSeq - NM_009466
RefSeq Peptide - NP_033492
swissprot - O70475
swissprot - Q3TS38
swissprot - D3YXP9
Ensembl - ENSMUSG00000029201
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ugdhENSDARG00000019838Danio rerio
 UGDHENSGALG00000041993Gallus gallus
 UGDHENSG00000109814Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001732  UDP-glucose/GDP-mannose dehydrogenase, N-terminal
 IPR008927  6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily
 IPR014026  UDP-glucose/GDP-mannose dehydrogenase, dimerisation
 IPR014027  UDP-glucose/GDP-mannose dehydrogenase, C-terminal
 IPR017476  UDP-glucose/GDP-mannose dehydrogenase
 IPR021157  Cytochrome c1, transmembrane anchor, C-terminal
 IPR028356  UDP-glucose 6-dehydrogenase, eukaryotic type
 IPR036220  UDP-glucose/GDP-mannose dehydrogenase, C-terminal domain superfamily
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001702 gastrulation with mouth forming second IMP
 biological_processGO:0006024 glycosaminoglycan biosynthetic process IBA
 biological_processGO:0006065 UDP-glucuronate biosynthetic process IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005829 cytosol IBA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0003979 UDP-glucose 6-dehydrogenase activity IDA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
 molecular_functionGO:0051287 NAD binding IEA


Pathways (from Reactome)
Pathway description
Formation of the active cofactor, UDP-glucuronate


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Ugdhtm1.1Xzh/Ugdhtm1.1Xzh,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA/J

 MP:0001347 absent lacrimal glands "missing the glands that secrete tears" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Ugdhtm1.1Xzh/Ugdhtm1.1Xzh,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA/J

Allelic Composition: Krastm4Tyj/Krastm4Tyj,Ugdhtm1.1Xzh/Ugdhtm1.1Xzh,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA/J

 MP:0001680 abnormal mesoderm development "failure or abnormality in the formation of the mesoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cops3tm2Jrl/Cops3tm2Jrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Cops3tm2Jrl/Cops3tm2Jrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Ugdhlzme/Ugdhlzme
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Taf7tm1.1Dss/Taf7tm1.2Dss,Tg(Cd8a*-cre)#Asin/0
Genetic Background: involves: C57BL/6

 MP:0002231 abnormal primitive streak morphology "anomaly in the midline ridge of the embryonic epiblast that later develops into mesoderm and endoderm" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ugdhlzme/Ugdhlzme
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cops3tm2Jrl/Cops3tm2Jrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0006323 abnormal extraembryonic mesoderm development "malformation of the mesoderm of the extraembryonic tissue that is involved in forming the amnion, chorion,yolk sac, and body stalk" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cops3tm2Jrl/Cops3tm2Jrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008932 abnormal embryonic tissue physiology "any functional anomaly in any of the tissues of the embryo proper" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ugdhtm1.1Xzh/Ugdhtm1.1Xzh,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA/J

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Ugdhtm1.1Xzh/Ugdhtm1.1Xzh,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA/J

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Cops3tm2Jrl/Cops3tm2Jrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011097 complete embryonic lethality before turning of embryo "death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Ugdhlzme/Ugdhlzme
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0011183 abnormal primitive endoderm morphology "any structural anomaly of the monolayer of cells derived from and located on the surface of inner cell mass, directly facing the blastocoele, and is separated from the more centrally located epiblast by basal lamina; the primitive endoderm give rises to the visceral endoderm and the parietal endoderm" [PMID:21123814]
Show

Allelic Composition: Cops3tm2Jrl/Cops3tm2Jrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0013331 abnormal lacrimal gland development "aberrant formation or incomplete differentiation of the paired almond-shaped glands, one for each eye, that secrete the aqueous layer of the tear film; each lacrimal gland develops through branching morphogenesis regulated by FGF signaling; at E12.5, the conjunctival epithelium at the temporal side of the mouse eyes invades the Fgf10-expressing mesenchyme to form the initial lacrimal gland bud; the bud elongates posteriorly until E15.5 when secondary branching begins to establish the complex tubuloalveolar structure; this eventually gives rise to the mature lacrimal gland composed of numerous ducts, acini and connective tissue" [MGI:Anna, PMID:22745308]
Show

Allelic Composition: Ugdhtm1.1Xzh/Ugdhtm1.1Xzh,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA/J

Allelic Composition: Krastm4Tyj/Krastm4Tyj,Ugdhtm1.1Xzh/Ugdhtm1.1Xzh,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000029201 Ugdh / O70475 / UDP-glucose dehydrogenase / O60701* / UDP-glucose 6-dehydrogenase*  / complex






 

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