ENSDARG00000026081


Danio rerio

Features
Gene ID: ENSDARG00000026081
  
Biological name :lhcgr
  
Synonyms : lhcgr / luteinizing hormone/choriogonadotropin receptor
  
Possible biological names infered from orthology : AC073082.1 / Lutropin-choriogonadotropic hormone receptor / P22888 / P30730
  
Species: Danio rerio
  
Chr. number: 13
Strand: 1
Band:
Gene start: 47573405
Gene end: 47618847
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000088230
NCBI entrez gene - 402920     See in Manteia.
RefSeq - NM_205625
RefSeq Peptide - NP_991188
swissprot - B8JME5
ZFIN ID - ZDB-GENE-040806-3
Ensembl - ENSDARG00000026081
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LHCGRENSGALG00000009095Gallus gallus
 AC073082.1ENSG00000279956Homo sapiens
 LHCGRENSG00000138039Homo sapiens
 LhcgrENSMUSG00000024107Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
fshr / follicle stimulating hormone receptor / P23945* / P35378*ENSDARG0000007149445
tshr / thyroid stimulating hormone receptor / P16473*ENSDARG0000003719545
lgr4 / E7FE13 / leucine-rich repeat containing G protein-coupled receptor 4 / A2ARI4* / Q9BXB1*ENSDARG0000006054223
rxfp2b / relaxin/insulin-like family peptide receptor 2b / RXFP2* / Q91ZZ5* / Q8WXD0* / Relaxin receptor 2 * / relaxin/insulin like family peptide receptor 2*ENSDARG0000001966019
rxfp1 / relaxin/insulin-like family peptide receptor 1 / Q6R6I7* / Q9HBX9* / Relaxin receptor 1 *ENSDARG0000009007119
rxfp2a / relaxin/insulin-like family peptide receptor 2a / RXFP2* / Q91ZZ5* / Q8WXD0* / Relaxin receptor 2 * / relaxin/insulin like family peptide receptor 2*ENSDARG0000003282018
rxfp2l / relaxin/insulin-like family peptide receptor 2, likeENSDARG0000006873118


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR002131  Glycoprotein hormone receptor family
 IPR002272  Follicle stimulating hormone receptor
 IPR002273  Lutropin-choriogonadotropic hormone receptor
 IPR017452  GPCR, rhodopsin-like, 7TM
 IPR024635  Gonadotropin hormone receptor, transmembrane domain
 IPR026906  Leucine rich repeat 5
 IPR032675  Leucine-rich repeat domain superfamily
 IPR034298  TSH/LHCG/FSH receptor


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001545 primary ovarian follicle growth IBA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IBA
 biological_processGO:0007190 activation of adenylate cyclase activity IBA
 biological_processGO:0007283 spermatogenesis IGI
 biological_processGO:0008584 male gonad development IMP
 biological_processGO:0008585 female gonad development IGI
 biological_processGO:0009755 hormone-mediated signaling pathway IBA
 biological_processGO:0030728 ovulation IMP
 biological_processGO:0042699 follicle-stimulating hormone signaling pathway IBA
 biological_processGO:0042700 luteinizing hormone signaling pathway IEA
 biological_processGO:0045670 regulation of osteoclast differentiation IBA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004963 follicle-stimulating hormone receptor activity IBA
 molecular_functionGO:0004964 luteinizing hormone receptor activity IDA
 molecular_functionGO:0008528 G-protein coupled peptide receptor activity IBA
 molecular_functionGO:0016500 protein-hormone receptor activity IEA


Pathways (from Reactome)
Pathway description
Hormone ligand-binding receptors
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000007 blood blood testosterone decreased amount , abnormal
blood androgen decreased amount , abnormal
Show

 ZFA:0000242 male organism male organism male sterile , abnormal
male organism sterile , abnormal
Show

 ZFA:0000303 female organism female organism absent , abnormal
female organism female semi-sterile , abnormal
female organism decreased fertility , abnormal
Show

 ZFA:0000403 ovary ovary increased size , abnormal
Show

 ZFA:0000598 testis testis immature , abnormal
testis increased amount , abnormal
testis decreased size , abnormal
testis decreased amount , abnormal
Show

 ZFA:0001264 ovarian follicle stage IV ovarian follicle stage IV increased amount , abnormal
Show

 ZFA:0001266 ovarian follicle stage III ovarian follicle stage III decreased amount , abnormal
Show

 ZFA:0001571 postovulatory follicle postovulatory follicle increased amount , abnormal
Show

 ZFA:0009006 sperm sperm absent , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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