ENSDARG00000030494


Danio rerio

Features
Gene ID: ENSDARG00000030494
  
Biological name :hfe2
  
Synonyms : hemochromatosis type 2 / hfe2
  
Possible biological names infered from orthology : hemochromatosis type 2 (juvenile) / Hemojuvelin / Q6ZVN8 / Q7TQ32
  
Species: Danio rerio
  
Chr. number: 16
Strand: -1
Band:
Gene start: 42883799
Gene end: 42894628
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000045599
Ensembl peptide - ENSDARP00000123796
NCBI entrez gene - 321932     See in Manteia.
RefSeq - NM_001045281
RefSeq Peptide - NP_001038746
swissprot - F8W533
swissprot - Q1JQE7
ZFIN ID - ZDB-GENE-030131-651
Ensembl - ENSDARG00000030494
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 HFE2ENSG00000168509Homo sapiens
 Hfe2ENSMUSG00000038403Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
rgma / repulsive guidance molecule family member a / Q6PCX7* / Q96B86* / Repulsive guidance molecule A * / repulsive guidance molecule BMP co-receptor a*ENSDARG0000001224838
rgmd / RGM domain family, member DENSDARG0000003401337
rgmb / repulsive guidance molecule family member b / Q6NW40* / repulsive guidance molecule BMP co-receptor b*ENSDARG0000007932336


Protein motifs (from Interpro)
Interpro ID Name
 IPR009496  Repulsive guidance molecule, C-terminal
 IPR010536  Repulsive guidance molecule, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0030509 BMP signaling pathway IEA
 biological_processGO:0030903 notochord development IMP
 biological_processGO:0055072 iron ion homeostasis IEA
 biological_processGO:0061053 somite development IMP
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0046658 anchored component of plasma membrane ISS
 cellular_componentGO:1990712 HFE-transferrin receptor complex IEA
 molecular_functionGO:0015026 coreceptor activity IBA
 molecular_functionGO:0036122 BMP binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000123 liver liver decreased size , abnormal
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 ZFA:0000135 notochord notochord undulate , abnormal
Show

 ZFA:0000155 somite somite decreased thickness , abnormal
somite U-shaped , abnormal
Show

 ZFA:0001094 whole organism whole organism undulate , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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