ENSDARG00000037429


Danio rerio

Features
Gene ID: ENSDARG00000037429
  
Biological name :tll1
  
Synonyms : O57460 / tll1 / tolloid-like 1
  
Possible biological names infered from orthology : O43897 / tolloid-like
  
Species: Danio rerio
  
Chr. number: 1
Strand: -1
Band:
Gene start: 20733102
Gene end: 20826023
  
Corresponding Affymetrix probe sets: Dr.571.1.S1_at (Zebrafish Array)   NM_131010_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000146714
Ensembl peptide - ENSDARP00000054471
NCBI entrez gene - 474335     See in Manteia.
RefSeq - NM_131010
RefSeq Peptide - NP_571085
swissprot - B3DJN6
swissprot - O57460
ZFIN ID - ZDB-GENE-041020-1
Ensembl - ENSDARG00000037429
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TLL1ENSGALG00000009567Gallus gallus
 TLL1ENSG00000038295Homo sapiens
 Tll1ENSMUSG00000053626Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
bmp1a / bone morphogenetic protein 1a / BMP1* / P13497* / bone morphogenetic protein 1*ENSDARG0000002807170
bmp1b / bone morphogenetic protein 1b / BMP1* / P98063* / P13497* / Bone morphotic protein 1 * / bone morphogenetic protein 1*ENSDARG0000002805365
cubn / cubilin (intrinsic factor-cobalamin receptor) / O60494* / cubilin*ENSDARG0000008701329
cdcp2 / CUB domain containing protein 2 / Q5VXM1* / Q8BQH6*ENSDARG0000007586614
pcolcea / procollagen C-endopeptidase enhancer a / Q61398* / PCOLCE* / Q15113* / procollagen C-endopeptidase enhancer* / Procollagen C-endopeptidase enhancer 1 *ENSDARG0000005691311
neto2b / neuropilin (NRP) and tolloid (TLL)-like 2b / NETO2* / Q8NC67* / neuropilin and tolloid like 2*ENSDARG0000011210011
pcolceb / procollagen C-endopeptidase enhancer b / Q61398* / PCOLCE* / Q15113* / procollagen C-endopeptidase enhancer* / Procollagen C-endopeptidase enhancer 1 *ENSDARG0000005205711
neto1l / neuropilin (NRP) and tolloid (TLL)-like 1, like / NETO1* / Q8TDF5* / Q8R4I7* / neuropilin and tolloid like 1* / Neuropilin and tolloid-like protein 1 *ENSDARG0000007159610
pcolce2a / procollagen C-endopeptidase enhancer 2a / Q9UKZ9* / Q8R4W6* / PCOLCE2* / procollagen C-endopeptidase enhancer 2*ENSDARG0000000845010
pimr62 / pcolce2b / procollagen C-endopeptidase enhancer 2b / Q9UKZ9* / Q8R4W6* / PCOLCE2* / procollagen C-endopeptidase enhancer 2*ENSDARG0000005557510
si:cabz01033205.3 / MFRP* / Q8K480* / Q9BY79* / membrane frizzled-related protein*ENSDARG0000008781410
neto2b / neuropilin (NRP) and tolloid (TLL)-like 2b / NETO2* / Q8NC67* / Q8BNJ6* / neuropilin and tolloid like 2* / Mus musculus neuropilin (NRP) and tolloid (TLL)-like 2 (Neto2), transcrip...ENSDARG0000006329310
neto1 / neuropilin (NRP) and tolloid (TLL)-like 1 / Q8TDF5* / Q8R4I7* / neuropilin and tolloid like 1* / Neuropilin and tolloid-like protein 1 *ENSDARG000000684839


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000742  EGF-like domain
 IPR000859  CUB domain
 IPR001506  Peptidase M12A
 IPR001881  EGF-like calcium-binding domain
 IPR006026  Peptidase, metallopeptidase
 IPR013032  EGF-like, conserved site
 IPR015446  Bone morphogenetic protein 1/tolloid-like protein
 IPR018097  EGF-like calcium-binding, conserved site
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR034036  Tolloid/BMP1 peptidase domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001568 blood vessel development IMP
 biological_processGO:0001707 mesoderm formation IMP
 biological_processGO:0001885 endothelial cell development IMP
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0009953 dorsal/ventral pattern formation IMP
 biological_processGO:0030513 positive regulation of BMP signaling pathway IMP
 biological_processGO:0035124 embryonic caudal fin morphogenesis IMP
 biological_processGO:0035162 embryonic hemopoiesis IMP
 biological_processGO:0036342 post-anal tail morphogenesis IMP
 biological_processGO:0048264 determination of ventral identity IMP
 cellular_componentGO:0005576 extracellular region NAS
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Degradation of the extracellular matrix
Collagen biosynthesis and modifying enzymes
Anchoring fibril formation
Crosslinking of collagen fibrils


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000040 median fin fold median fin fold hypoplastic , abnormal
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 ZFA:0000077 tail bud tail bud decreased length , abnormal
tail bud increased size , abnormal
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 ZFA:0000108 fin fin decreased size , abnormal
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 ZFA:0000135 notochord notochord bent , abnormal
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 ZFA:0000292 surface structure surface structure quality , abnormal
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 ZFA:0001058 caudal fin caudal fin ventral region hypoplastic , abnormal
caudal fin hypoplastic , abnormal
caudal fin aplastic , abnormal
caudal fin absent , abnormal
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 ZFA:0001069 ventral fin fold ventral fin fold absent , abnormal
ventral fin fold hypoplastic , abnormal
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 ZFA:0001094 whole organism whole organism viability , abnormal
whole organism wholly dorsalized , abnormal
whole organism lethal (sensu genetics) , abnormal
whole organism dorsal-ventral axis absent , abnormal
whole organism has extra parts of type post-vent region , abnormal
whole organism shape , abnormal
whole organism quality , abnormal
whole organism oblong , abnormal
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 ZFA:0001117 post-vent region post-vent region quality , abnormal
post-vent region bifurcated , abnormal
post-vent region deformed , abnormal
post-vent region decreased length , abnormal
post-vent region has extra parts of type tail bud , abnormal
post-vent region has extra parts of type notochord , abnormal
post-vent region has extra parts of type muscle , abnormal
post-vent region morphology , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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