ENSDARG00000038386


Danio rerio

Features
Gene ID: ENSDARG00000038386
  
Biological name :ascl1a
  
Synonyms : achaete-scute family bHLH transcription factor 1a / ascl1a / Q90259
  
Possible biological names infered from orthology : achaete-scute family bHLH transcription factor 1 / Achaete-scute homolog 1 / ASCL1 / P50553 / Q02067
  
Species: Danio rerio
  
Chr. number: 4
Strand: 1
Band:
Gene start: 17417111
Gene end: 17419193
  
Corresponding Affymetrix probe sets: Dr.314.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000056004
NCBI entrez gene - 30466     See in Manteia.
swissprot - Q90259
ZFIN ID - ZDB-GENE-980526-90
Ensembl - ENSDARG00000038386
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ASCL1ENSGALG00000037082Gallus gallus
 ASCL1ENSG00000139352Homo sapiens
 Ascl1ENSMUSG00000020052Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ascl1b / Q90260 / achaete-scute family bHLH transcription factor 1bENSDARG0000010162861


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002070 epithelial cell maturation IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IBA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0021575 hindbrain morphogenesis IMP
 biological_processGO:0021984 adenohypophysis development IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031099 regeneration IMP
 biological_processGO:0031103 axon regeneration IMP
 biological_processGO:0043697 cell dedifferentiation IGI
 biological_processGO:0045666 positive regulation of neuron differentiation ISS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0048566 embryonic digestive tract development IMP
 biological_processGO:0050767 regulation of neurogenesis IBA
 biological_processGO:0060575 intestinal epithelial cell differentiation IMP
 biological_processGO:0061195 taste bud formation IMP
 biological_processGO:0061549 sympathetic ganglion development IMP
 biological_processGO:0070654 sensory epithelium regeneration IGI
 cellular_componentGO:0005634 nucleus IC
 cellular_componentGO:0090575 RNA polymerase II transcription factor complex IBA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA
 molecular_functionGO:0000989 transcription factor activity, transcription factor binding ISS
 molecular_functionGO:0003677 DNA binding ISS
 molecular_functionGO:0003700 DNA-binding transcription factor activity IBA
 molecular_functionGO:0043565 sequence-specific DNA binding IPI
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain quality , abnormal
Show

 ZFA:0000029 hindbrain hindbrain decreased width , abnormal
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 ZFA:0000032 hypothalamus hypothalamus morphology , abnormal
Show

 ZFA:0000076 swim bladder swim bladder decreased volume , abnormal
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 ZFA:0000118 hypophysis hypophysis quality , abnormal
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 ZFA:0000706 posterior intestine posterior intestine peristalsis decreased occurrence , abnormal
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 ZFA:0001074 taste bud taste bud physical quality , abnormal
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 ZFA:0001155 enteric nervous system enteric nervous system lacks all parts of type enteric neuron , abnormal
enteric nervous system has fewer parts of type enteric neuron , abnormal
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 ZFA:0005124 intestinal epithelium intestinal epithelium lacks parts or has fewer parts of type goblet cell , abnormal
intestinal epithelium lacks parts or has fewer parts of type enteroendocrine cell , abnormal
intestinal epithelium Notch signaling pathway process quality , abnormal
intestinal epithelium enteroendocrine cell undifferentiated , abnormal
Show

 ZFA:0005807 intestine lumen intestine lumen anterior region increased diameter , abnormal
Show

 ZFA:0009280 Muller cell Muller cell cell proliferation decreased occurrence , abnormal
Show

 ZFA:0009310 retinal ganglion cell retinal ganglion cell axon regeneration decreased occurrence , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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