ENSMUSG00000020052


Mus musculus

Features
Gene ID: ENSMUSG00000020052
  
Biological name :Ascl1
  
Synonyms : Achaete-scute homolog 1 / Ascl1 / Q02067
  
Possible biological names infered from orthology : achaete-scute family bHLH transcription factor 1 / P50553
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: C1
Gene start: 87490819
Gene end: 87493660
  
Corresponding Affymetrix probe sets: 10371578 (MoGene1.0st)   1437086_at (Mouse Genome 430 2.0 Array)   1450164_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020243
NCBI entrez gene - 17172     See in Manteia.
MGI - MGI:96919
RefSeq - NM_008553
RefSeq Peptide - NP_032579
swissprot - Q02067
Ensembl - ENSMUSG00000020052
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ascl1aENSDARG00000038386Danio rerio
 ASCL1ENSGALG00000037082Gallus gallus
 ASCL1ENSG00000139352Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ascl2 / O35885 / Achaete-scute homolog 2 / Q99929* / achaete-scute family bHLH transcription factor 2*ENSMUSG0000000924844
Ascl4 / achaete-scute family bHLH transcription factor 4 / Q6XD76*ENSMUSG0000008511122
Ascl5 / achaete-scute family bHLH transcription factor 5 / Q7RTU5*ENSMUSG0000009791822
Ascl3 / Q9JJR7 / Achaete-scute homolog 3 / Q9NQ33* / achaete-scute family bHLH transcription factor 3*ENSMUSG0000003595119


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR015660  Achaete-scute transcription factor-related
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001764 neuron migration IMP
 biological_processGO:0003358 noradrenergic neuron development IMP
 biological_processGO:0003359 noradrenergic neuron fate commitment IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IDA
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IMP
 biological_processGO:0007389 pattern specification process IMP
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007400 neuroblast fate determination IMP
 biological_processGO:0007405 neuroblast proliferation IGI
 biological_processGO:0008593 regulation of Notch signaling pathway IMP
 biological_processGO:0010001 glial cell differentiation IGI
 biological_processGO:0010226 response to lithium ion IEA
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0014003 oligodendrocyte development IMP
 biological_processGO:0021527 spinal cord association neuron differentiation IMP
 biological_processGO:0021529 spinal cord oligodendrocyte cell differentiation IGI
 biological_processGO:0021530 spinal cord oligodendrocyte cell fate specification IMP
 biological_processGO:0021750 vestibular nucleus development IMP
 biological_processGO:0021779 oligodendrocyte cell fate commitment IMP
 biological_processGO:0021879 forebrain neuron differentiation IEA
 biological_processGO:0021892 cerebral cortex GABAergic interneuron differentiation IEA
 biological_processGO:0021902 commitment of neuronal cell to specific neuron type in forebrain IMP
 biological_processGO:0021954 central nervous system neuron development IMP
 biological_processGO:0021987 cerebral cortex development IMP
 biological_processGO:0022008 neurogenesis IEA
 biological_processGO:0030154 cell differentiation IMP
 biological_processGO:0030182 neuron differentiation IDA
 biological_processGO:0030856 regulation of epithelial cell differentiation IMP
 biological_processGO:0032526 response to retinoic acid IEA
 biological_processGO:0042127 regulation of cell proliferation IDA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043525 positive regulation of neuron apoptotic process IMP
 biological_processGO:0045665 negative regulation of neuron differentiation IEA
 biological_processGO:0045666 positive regulation of neuron differentiation IEA
 biological_processGO:0045747 positive regulation of Notch signaling pathway IMP
 biological_processGO:0045787 positive regulation of cell cycle IDA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048469 cell maturation IMP
 biological_processGO:0048484 enteric nervous system development TAS
 biological_processGO:0048485 sympathetic nervous system development TAS
 biological_processGO:0048486 parasympathetic nervous system development TAS
 biological_processGO:0048663 neuron fate commitment IDA
 biological_processGO:0048665 neuron fate specification IDA
 biological_processGO:0048666 neuron development IMP
 biological_processGO:0048699 generation of neurons IMP
 biological_processGO:0048709 oligodendrocyte differentiation IMP
 biological_processGO:0050767 regulation of neurogenesis IMP
 biological_processGO:0050769 positive regulation of neurogenesis IMP
 biological_processGO:0050883 musculoskeletal movement, spinal reflex action IMP
 biological_processGO:0051593 response to folic acid IEA
 biological_processGO:0060163 subpallium neuron fate commitment IMP
 biological_processGO:0060165 regulation of timing of subpallium neuron differentiation IMP
 biological_processGO:0060166 olfactory pit development IMP
 biological_processGO:0060579 ventral spinal cord interneuron fate commitment IMP
 biological_processGO:0061100 lung neuroendocrine cell differentiation IMP
 biological_processGO:0061102 stomach neuroendocrine cell differentiation IMP
 biological_processGO:0061103 carotid body glomus cell differentiation IMP
 biological_processGO:0061104 adrenal chromaffin cell differentiation IMP
 biological_processGO:0061549 sympathetic ganglion development IMP
 biological_processGO:0070849 response to epidermal growth factor IEA
 biological_processGO:0071259 cellular response to magnetism IEA
 biological_processGO:2000179 positive regulation of neural precursor cell proliferation IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0043025 neuronal cell body IDA
 cellular_componentGO:0090575 RNA polymerase II transcription factor complex IBA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000989 transcription factor activity, transcription factor binding IDA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003690 double-stranded DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0043425 bHLH transcription factor binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0070888 E-box binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000934 abnormal telencephalon development "malformed or incomplete differentiation of the anterior division of the embryonic prosencephalon " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]
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Allelic Composition: Hdac1tm1Sei/Hdac1tm1Sei
Genetic Background: either: (involves: 129P2/OlaHsd * 129/Sv) or (involves: 129P2/OlaHsd * C57BL/6)

Allelic Composition: Ascl1tm1And/Ascl1tm1And
Genetic Background: involves: 129/Sv

 MP:0001008 abnormal sympathetic ganglia morphology "malformed or absent groups of neuronal cell bodies of the autonomic nervous system" [J:18048]
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Allelic Composition: Mdm2tm1Glo/Mdm2tm1Glo,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J

 MP:0001034 abnormal parasympathetic ganglia morphology "malformation or absence of the ganglia of the parasympathetic nervous system, including the ciliary, pterygopalatine, submandibular, and otic ganglia in the cranial region and intrinsic (terminal) ganglia associated with target organs in the thorax and abdomen" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mdm2tm1Glo/Mdm2tm1Glo,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J

 MP:0001046 abnormal enteric neuron morphology "malformed or absent neurons that innervate the esophagus, stomach, small and large bowel" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mdm2tm1Glo/Mdm2tm1Glo,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J

 MP:0001048 absent enteric neurons "missing neurons that innervate the esophagus, stomach, small and large bowel" [Principles of Neural Science:ISBN 0-8385-8034-3, J:49471]
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Allelic Composition: Mdm2tm1Glo/Mdm2tm1Glo,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J

 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Ascl1tm1(Neurog2)Fgu/Ascl1tm1(Neurog2)Fgu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001327 reduced retinal photoreceptor cell number "fewer than the expected number of rods and/or cones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ascl1tm1And/Ascl1tm1And,Neurod4tm1Kag/Neurod4tm1Kag,Neurog2tm1Fgu/Neurog2tm1Fgu
Genetic Background: involves: 129/Sv * C57BL/6 * CBA * ICR

Allelic Composition: Ascl1tm1And/Ascl1tm1And,Neurod1tm1Jle/Neurod1tm1Jle
Genetic Background: either: (involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * ICR) or (involves: 129S2/SvPas * 129S4/SvJaeSor * ICR)

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Mdm2tm1Glo/Mdm2tm1Glo,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J

 MP:0002095 abnormal skin pigmentation "variation of skin color or complexion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mdm2tm1Glo/Mdm2tm1Glo,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pou5f1tm1.1(cre/Esr1*)Yseg/Pou5f1+
Genetic Background: C57BL/6-Pou5f1tm1.1(cre/Esr1*)Yseg

 MP:0002983 increased retinal ganglion cell number "greater number of cells in the innermost nuclear layer of the retina, which projects axons through the optic nerve to the brain " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Ascl1tm1And/Ascl1tm1And,Neurod4tm1Kag/Neurod4tm1Kag,Neurog2tm1Fgu/Neurog2tm1Fgu
Genetic Background: involves: 129/Sv * C57BL/6 * CBA * ICR

Allelic Composition: Ascl1tm1And/Ascl1tm1And,Neurod1tm1Jle/Neurod1tm1Jle,Neurod4tm1Kag/Neurod4tm1Kag
Genetic Background: involves: 129/Sv * C57BL/6 * CBA * ICR

 MP:0003202 abnormal neuron apoptosis "change in the timing or the number of neurons undergoing programmed cell death" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Errfi1tm1Kln/Errfi1tm1Kln
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

Allelic Composition: Ascl1tm1And/Ascl1tm1And
Genetic Background: involves: 129/Sv

 MP:0003661 abnormal locus ceruleus "anomaly in a dense cluster of neurons within the dorsorostral pons; it is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic" [J:96328, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Errfi1tm1Kln/Errfi1tm1Kln
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0003727 abnormal retinal layer morphology "malformation in any of the layers that make up the retina" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ascl1tm1And/Ascl1tm1And,Neurod4tm1Kag/Neurod4tm1Kag,Neurog2tm1Fgu/Neurog2tm1Fgu
Genetic Background: involves: 129/Sv * C57BL/6 * CBA * ICR

Allelic Composition: Ascl1tm1And/Ascl1tm1And,Neurod1tm1Jle/Neurod1tm1Jle,Neurod4tm1Kag/Neurod4tm1Kag
Genetic Background: involves: 129/Sv * C57BL/6 * CBA * ICR

 MP:0003733 abnormal inner nuclear layer morphology "malformation/anomalous structure of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Ascl1tm1And/Ascl1tm1And,Neurod4tm1Kag/Neurod4tm1Kag,Neurog2tm1Fgu/Neurog2tm1Fgu
Genetic Background: involves: 129/Sv * C57BL/6 * CBA * ICR

Allelic Composition: Ascl1tm1And/Ascl1tm1And,Neurod1tm1Jle/Neurod1tm1Jle,Neurod4tm1Kag/Neurod4tm1Kag
Genetic Background: involves: 129/Sv * C57BL/6 * CBA * ICR

 MP:0003861 abnormal nervous system development "impaired or altered growth of the components of the nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pou5f1tm1.1(cre/Esr1*)Yseg/Pou5f1+
Genetic Background: C57BL/6-Pou5f1tm1.1(cre/Esr1*)Yseg

 MP:0004077 abnormal striatum morphology "malformation of a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Ascl1tm1And/Ascl1tm1And,Gsx2tm1Ssp/Gsx2tm1Ssp
Genetic Background: involves: 129 * 129S2/SvPas

 MP:0004100 abnormal spinal cord interneuron morphology "malformation or absence of neurons that exclusively interact with other neurons in the spinal cord" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Errfi1tm1Kln/Errfi1tm1Kln
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

Allelic Composition: Ascl1tm1And/Ascl1tm1And
Genetic Background: involves: 129/Sv

Allelic Composition: Ascl1tm1And/Ascl1tm1And,Neurog2tm1Fgu/Neurog2tm1Fgu
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ

Allelic Composition: Ascl1tm1And/Ascl1tm1And,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Tg(Ascl1-EGFP,-cre)1Jejo/0
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6 * DBA

Allelic Composition: Ascl1tm1(Neurog2)Fgu/Ascl1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004101 abnormal brain interneuron morphology "malformation or absence of neurons that exclusively interact with other neurons in the brain; this includes most brain neuronal cell types" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ascl1tm1And/Ascl1tm1And,Gsx2tm1Ssp/Gsx2tm1Ssp
Genetic Background: involves: 129 * 129S2/SvPas

 MP:0004201 fetal growth retardation "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cfbtm1Hrc/Cfb+,Cfhtm1Mbo/Cfhtm1Mbo
Genetic Background: involves: 129S/Sv * C57BL/6

 MP:0004277 abnormal lateral ganglionic eminence morphology "any structural anomaly of a distinct elevation of a transient proliferating cell mass of the fetal subventricular zone; this mass contributes most of its cells to the striatum; however, neocortex, thalamus, septum and olfactory bulb neurons are also partly derived from the LGE" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
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Allelic Composition: Ascl1tm1And/Ascl1tm1And,Gsx2tm1Ssp/Gsx2tm1Ssp
Genetic Background: involves: 129 * 129S2/SvPas

 MP:0004279 abnormal rostral migratory stream morphology "any structural anomaly of the transient structure formed by neurons migrating from the subventricular zone into the olfactory bulbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ascl1tm1And/Ascl1tm1And,Gsx2tm1Ssp/Gsx2tm1Ssp
Genetic Background: involves: 129 * 129S2/SvPas

 MP:0004981 decreased neuronal precursor cell number "reduced number of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ascl1tm1And/Ascl1tm1And,Neurog2tm4Fgu/Neurog2tm4Fgu
Genetic Background: involves: 129 * MF1

 MP:0005547 abnormal Muller cell morphology "anomalous structure of the elongated neuroglial cells that traverse all the layers of the retina and that act as supporting elements" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Neurod1tm1Jle/Neurod1tm1Jle,Neurod4tm1Kag/Neurod4tm1Kag
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA * ICR

Allelic Composition: Ascl1tm1And/Ascl1tm1And,Neurod4tm1Kag/Neurod4tm1Kag,Neurog2tm1Fgu/Neurog2tm1Fgu
Genetic Background: involves: 129/Sv * C57BL/6 * CBA * ICR

Allelic Composition: Ascl1tm1And/Ascl1tm1And,Neurod1tm1Jle/Neurod1tm1Jle,Neurod4tm1Kag/Neurod4tm1Kag
Genetic Background: involves: 129/Sv * C57BL/6 * CBA * ICR

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Enpp1asj/Enpp1asj
Genetic Background: C57BL/6J-Enpp1asj/GrsrJ

 MP:0006068 abnormal horizontal cell morphology "anomalous structure of the laterally interconnecting neurons in the outer plexiform layer" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ascl1tm1And/Ascl1tm1And,Neurod4tm1Kag/Neurod4tm1Kag,Neurog2tm1Fgu/Neurog2tm1Fgu
Genetic Background: involves: 129/Sv * C57BL/6 * CBA * ICR

 MP:0006073 abnormal retinal bipolar cell morphology "anomalous structure of the cells that transmit signals from the photoreceptors to retinal amacrine and ganglion cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92623:]
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Allelic Composition: Ascl1tm1And/Ascl1tm1And,Neurod4tm1Kag/Neurod4tm1Kag,Neurog2tm1Fgu/Neurog2tm1Fgu
Genetic Background: involves: 129/Sv * C57BL/6 * CBA * ICR

Allelic Composition: Ascl1tm1And/Ascl1tm1And,Neurod1tm1Jle/Neurod1tm1Jle,Neurod4tm1Kag/Neurod4tm1Kag
Genetic Background: involves: 129/Sv * C57BL/6 * CBA * ICR

 MP:0006092 abnormal olfactory neuron morphology "malformation in the neurons that are activated by specific odorants" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92950]
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Allelic Composition: Mdm2tm1Glo/Mdm2tm1Glo,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Ascl1tm1And/Ascl1tm1And,Gsx2tm1Ssp/Gsx2tm1Ssp
Genetic Background: involves: 129 * 129S2/SvPas

 MP:0006096 absent retinal bipolar cells "absence of the cells that transmit signals from the photoreceptors to retinal amacrine and ganglion cells" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator, J:65410]
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Allelic Composition: Ascl1tm1And/Ascl1tm1And,Neurod4tm1Kag/Neurod4tm1Kag
Genetic Background: either: (involves: 129S2/SvPas * C57BL/6 * CBA) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA)

 MP:0006104 abnormal tectum morphology "any structural alterations or malfunction of the rostral part of the midbrain roof" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator, J:65762]
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Allelic Composition: Ascl1tm1And/Ascl1tm1And,Neurod4tm1Kag/Neurod4tm1Kag
Genetic Background: either: (involves: 129S2/SvPas * C57BL/6 * CBA) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA)

 MP:0006105 reduced tectum size "reduced size of the rostral part of the midbrain roof" [smb:Susan M Bello, Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65410]
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Allelic Composition: Ascl1tm1And/Ascl1tm1And,Neurod4tm1Kag/Neurod4tm1Kag
Genetic Background: either: (involves: 129S2/SvPas * C57BL/6 * CBA) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA)

 MP:0008106 decreased amacrine cell number "reduction in the number of one of the three types of interneurons found in the inner nuclear layer of the mature retina" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ascl1tm1And/Ascl1tm1And,Neurod4tm1Kag/Neurod4tm1Kag,Neurog2tm1Fgu/Neurog2tm1Fgu
Genetic Background: involves: 129/Sv * C57BL/6 * CBA * ICR

 MP:0008789 abnormal olfactory epithelium morphology "any structural anomaly in the epithelial cells that line the interior of the nose" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Mdm2tm1Glo/Mdm2tm1Glo,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Mdm2tm1Glo/Mdm2tm1Glo,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ascl1tm1And/Ascl1tm1And,Neurod4tm1Kag/Neurod4tm1Kag
Genetic Background: either: (involves: 129S2/SvPas * C57BL/6 * CBA) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA)

 MP:0010916 decreased solitary pulmonary neuroendocrine cell number "decreased number of the specialized non-ciliated, round- to oval-shaped epithelial cells found as solitary cells in the nasal respiratory epithelium and the mucosa of the larynx, trachea and bronchi up to the terminal bronchioles; PNECs are the first cell type to differentiate during early fetal lung development, produce amine (e.g. serotonin, 5-HT) and peptides (e.g. bombesin, calcitonin) with growth factor-like properties, and appear to be involved in processes ranging from lung development and respiratory physiology to repair, disease and carcinogenesis" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Lamb2tm1Jrs/Lamb2tm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0010917 absent solitary pulmonary neuroendocrine cells "absence of the specialized non-ciliated, round- to oval-shaped epithelial cells found as solitary cells in the nasal respiratory epithelium and the mucosa of the larynx, trachea and bronchi up to the terminal bronchioles; PNECs are the first cell type to differentiate during early fetal lung development, produce amine (e.g. serotonin, 5-HT) and peptides (e.g. bombesin, calcitonin) with growth factor-like properties, and appear to be involved in processes ranging from lung development and respiratory physiology to repair, disease and carcinogenesis" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ascl1tm1And/Ascl1tm1And
Genetic Background: involves: 129/Sv

 MP:0010920 decreased number of pulmonary neuroendocrine bodies "reduction in the number of the corpuscular, organoid structures composed of PNECs, found as distinctive innervated clusters only within intrapulmonary airways, where they appear concentrated at airway branch points; NEBs reach from the basement membrane to the airway lumen and are thought to function as oxygen sensors" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Lamb2tm1Jrs/Lamb2tm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0010921 absent pulmonary neuroendocrine bodies "absence of the corpuscular, organoid structures composed of PNECs, found as distinctive innervated clusters only within intrapulmonary airways, where they appear concentrated at airway branch points; NEBs reach from the basement membrane to the airway lumen and are thought to function as oxygen sensors" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ascl1tm1And/Ascl1tm1And
Genetic Background: involves: 129/Sv

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Mdm2tm1Glo/Mdm2tm1Glo,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Ascl1tm1And/Ascl1tm1And
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ascl1tm1(Neurog2)Fgu/Ascl1tm1(Neurog2)Fgu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ascl1tm1.1(cre/ERT2)Jejo/Ascl1tm1.1(cre/ERT2)Jejo
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * ICR

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Ascl1tm1And/Ascl1tm1And,Neurod4tm1Kag/Neurod4tm1Kag,Neurog2tm1Fgu/Neurog2tm1Fgu
Genetic Background: involves: 129/Sv * C57BL/6 * CBA * ICR

Allelic Composition: Ascl1tm1And/Ascl1tm1And,Neurod1tm1Jle/Neurod1tm1Jle,Neurod4tm1Kag/Neurod4tm1Kag
Genetic Background: involves: 129/Sv * C57BL/6 * CBA * ICR

Allelic Composition: Ascl1tm1And/Ascl1tm1And,Neurog2tm1Fgu/Neurog2tm1Fgu
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * ICR

Allelic Composition: Ascl1tm1And/Ascl1tm1And,Neurod4tm1Kag/Neurod4tm1Kag
Genetic Background: involves: 129/Sv * C57BL/6 * CBA * ICR

Allelic Composition: Ascl1tm1And/Ascl1tm1And,Neurod1tm1Jle/Neurod1tm1Jle
Genetic Background: either: (involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * ICR) or (involves: 129S2/SvPas * 129S4/SvJaeSor * ICR)

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Ascl1tm1And/Ascl1tm1And,Neurod4tm1Kag/Neurod4tm1Kag
Genetic Background: either: (involves: 129S2/SvPas * C57BL/6 * CBA) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA)

 MP:0011827 impaired neuron differentiation "decreased production of or inability to produce the mature cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith]
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Allelic Composition: Ascl1tm1And/Ascl1tm1And
Genetic Background: involves: 129/Sv

 MP:0012069 abnormal horizontal basal cell morphology "any structural anomaly of the flat or angular epithelial cell with condensed nuclei and darkly staining cytoplasm containing numerous intermediate filaments inserted into desmosomes contacting surrounding supporting cells, that lie in contact with the basal lamina of olfactory epithelium" [CL:0002184]
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Allelic Composition: Trp63tm1Sin/Trp63tm1Sin
Genetic Background: involves: C57BL/6

 MP:0020394 decreased neuronal precursor proliferation "reduction in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:anna]
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Allelic Composition: Ascl1tm1And/Ascl1tm1And
Genetic Background: involves: 129/Sv

 MP:0030005 increased retinal apoptosis "increase in the number of cells in the retina undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Ascl1tm1And/Ascl1tm1And,Neurod1tm1Jle/Neurod1tm1Jle,Neurod4tm1Kag/Neurod4tm1Kag
Genetic Background: involves: 129/Sv * C57BL/6 * CBA * ICR

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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