ENSMUSG00000009248


Mus musculus

Features
Gene ID: ENSMUSG00000009248
  
Biological name :Ascl2
  
Synonyms : Achaete-scute homolog 2 / Ascl2 / O35885
  
Possible biological names infered from orthology : achaete-scute family bHLH transcription factor 2 / Q99929
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: F5
Gene start: 142966829
Gene end: 142969264
  
Corresponding Affymetrix probe sets: 10569385 (MoGene1.0st)   1422396_s_at (Mouse Genome 430 2.0 Array)   1432018_at (Mouse Genome 430 2.0 Array)   1460514_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000009392
Ensembl peptide - ENSMUSP00000113012
NCBI entrez gene - 17173     See in Manteia.
MGI - MGI:96920
RefSeq - XM_011241984
RefSeq - NM_008554
RefSeq - XM_006508498
RefSeq Peptide - NP_032580
swissprot - O35885
swissprot - Q3TJR9
swissprot - D3Z7Q6
Ensembl - ENSMUSG00000009248
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ASCL2ENSG00000183734Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ascl1 / Q02067 / Achaete-scute homolog 1 / P50553* / achaete-scute family bHLH transcription factor 1*ENSMUSG0000002005239
Ascl4 / achaete-scute family bHLH transcription factor 4 / Q6XD76*ENSMUSG0000008511121
Ascl5 / achaete-scute family bHLH transcription factor 5 / Q7RTU5*ENSMUSG0000009791819
Ascl3 / Q9JJR7 / Achaete-scute homolog 3 / Q9NQ33* / achaete-scute family bHLH transcription factor 3*ENSMUSG0000003595117


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR015660  Achaete-scute transcription factor-related
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0001890 placenta development IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0010626 negative regulation of Schwann cell proliferation IEA
 biological_processGO:0030154 cell differentiation IMP
 biological_processGO:0035019 somatic stem cell population maintenance IMP
 biological_processGO:0050767 regulation of neurogenesis IBA
 biological_processGO:0060708 spongiotrophoblast differentiation IMP
 biological_processGO:0060712 spongiotrophoblast layer development IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0090575 RNA polymerase II transcription factor complex IBA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0070888 E-box binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001712 abnormal placental development "malformed or incomplete differentiation of the organ of metabolic exchange between the fetus and mother" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
Show

Allelic Composition: Wastm1Sbs/Wastm1Sbs
Genetic Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6)

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Eomestm1Rob/Eomestm2.1Rob,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0002836 abnormal chorion "malformations of the outermost extraembryonic membrane" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Wastm1Sbs/Wastm1Sbs
Genetic Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6)

Allelic Composition: Ascl2tm1Alj/Ascl2tm1Alj
Genetic Background: involves: 129 * CD-1

Allelic Composition: Ascl2tm1Alj/Ascl2+
Genetic Background: involves: 129 * CD-1

 MP:0003123 paternal imprinting "specific loci are inactivated during spermatogenesis and are not expressed in offspring " [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator, llw2:Linda Washburn, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ascl2tm1Alj/Ascl2+
Genetic Background: involves: 129 * CD-1

 MP:0003787 abnormal imprinting "defect in the normal inactivation of specific loci during gametogenesis" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kcnq1ot1tm1.1Mjh/Del(7Ins2-Tel)1Lef
Genetic Background: involves: 129 * C57BL/6 * ICR

 MP:0004255 abnormal spongiotrophoblast layer morphology "anomaly in the structure of the outer structural layer of the rodent placenta" [PMID:11433360]
Show

Allelic Composition: Ascl2tm1Alj/Ascl2+
Genetic Background: involves: 129 * CD-1

 MP:0004841 abnormal small intestine crypts of Lieberkuhn morphology "any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the small intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: F3tm1Jld/F3+
Genetic Background: involves: 129P2/OlaHsd * NIH Black Swiss

 MP:0008800 increased small intestinal crypt cell apoptosis "increase in the number of small intestinal crypt cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: F3tm1Jld/F3+
Genetic Background: involves: 129P2/OlaHsd * NIH Black Swiss

 MP:0008803 abnormal placental labyrinth vasculature morphology "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Wastm1Sbs/Wastm1Sbs
Genetic Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6)

 MP:0008959 abnormal spongiotrophoblast cell morphology "any structural anomaly of a trophoblast cell that arises in the junctional zone of the placenta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: SpastM1Gri/Spast+
Genetic Background: B6.C-SpastM1Gri

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Ascl2tm1Alj/Ascl2+
Genetic Background: involves: 129 * CD-1

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Wastm1Sbs/Wastm1Sbs
Genetic Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6)

Allelic Composition: Ascl2tm1Alj/Ascl2tm1Alj
Genetic Background: involves: 129 * CD-1

 MP:0012100 absent spongiotrophoblast "absence of the middle layer of the placenta between the outermost giant cells and the innermost labyrinth layer; it has a structural role and also produces several layer-specific secreted factors" [MGI:csmith]
Show

Allelic Composition: Wastm1Sbs/Wastm1Sbs
Genetic Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6)

Allelic Composition: Ascl2tm1Alj/Ascl2tm1Alj
Genetic Background: involves: 129 * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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