ENSG00000183734


Homo sapiens

Features
Gene ID: ENSG00000183734
  
Biological name :ASCL2
  
Synonyms : achaete-scute family bHLH transcription factor 2 / ASCL2 / Q99929
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: p15.5
Gene start: 2268495
Gene end: 2270952
  
Corresponding Affymetrix probe sets: 207607_at (Human Genome U133 Plus 2.0 Array)   229215_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000332293
NCBI entrez gene - 430     See in Manteia.
OMIM - 601886
RefSeq - NM_005170
RefSeq Peptide - NP_005161
swissprot - Q99929
Ensembl - ENSG00000183734
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Ascl2ENSMUSG00000009248Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ASCL1 / P50553 / achaete-scute family bHLH transcription factor 1ENSG0000013935247
ASCL5 / Q7RTU5 / achaete-scute family bHLH transcription factor 5ENSG0000023223726
ASCL4 / Q6XD76 / achaete-scute family bHLH transcription factor 4ENSG0000018785525
ASCL3 / Q9NQ33 / achaete-scute family bHLH transcription factor 3ENSG0000017600921


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR015660  Achaete-scute transcription factor-related
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0001666 response to hypoxia IEP
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0001890 placenta development IEA
 biological_processGO:0006351 transcription, DNA-templated IDA
 biological_processGO:0006355 regulation of transcription, DNA-templated NAS
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0010626 negative regulation of Schwann cell proliferation IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0035019 somatic stem cell population maintenance IEA
 biological_processGO:0050767 regulation of neurogenesis IBA
 biological_processGO:0060708 spongiotrophoblast differentiation IEA
 biological_processGO:0060712 spongiotrophoblast layer development IEP
 cellular_componentGO:0005634 nucleus NAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0090575 RNA polymerase II transcription factor complex IBA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0070888 E-box binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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