ENSDARG00000039077


Danio rerio

Features
Gene ID: ENSDARG00000039077
  
Biological name :tyr
  
Synonyms : tyr / tyrosinase
  
Possible biological names infered from orthology : P11344 / P14679
  
Species: Danio rerio
  
Chr. number: 15
Strand: 1
Band:
Gene start: 43799258
Gene end: 43818697
  
Corresponding Affymetrix probe sets: Dr.19561.1.S1_at (Zebrafish Array)   NM_131013_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000111575
NCBI entrez gene - 30207     See in Manteia.
RefSeq - NM_131013
RefSeq Peptide - NP_571088
swissprot - F1QDZ4
ZFIN ID - ZDB-GENE-991026-3
Ensembl - ENSDARG00000039077
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TYRENSGALG00000017237Gallus gallus
 TYRENSG00000077498Homo sapiens
 TyrENSMUSG00000004651Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
dct / dopachrome tautomerase / P29812* / P40126* / L-dopachrome tautomerase *ENSDARG0000000600840
tyrp1a / tyrosinase-related protein 1a / TYRP1* / P17643* / tyrosinase related protein 1*ENSDARG0000002920437
tyrp1b / tyrosinase-related protein 1b / TYRP1* / P07147* / P17643* / tyrosinase related protein 1*ENSDARG0000005615137


Protein motifs (from Interpro)
Interpro ID Name
 IPR002227  Tyrosinase copper-binding domain
 IPR008922  Uncharacterised domain, di-copper centre


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006585 dopamine biosynthetic process from tyrosine IMP
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0032438 melanosome organization IMP
 biological_processGO:0043473 pigmentation IMP
 biological_processGO:0048066 developmental pigmentation IMP
 biological_processGO:0050935 iridophore differentiation IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004097 catechol oxidase activity IMP
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Melanin biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000107 eye eye red , abnormal
eye catechol oxidase activity disrupted , abnormal
eye decreased size , abnormal
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 ZFA:0000144 retinal pigmented epithelium retinal pigmented epithelium quality , abnormal
retinal pigmented epithelium unpigmented , abnormal
retinal pigmented epithelium decreased pigmentation , abnormal
retinal pigmented epithelium melanosome immature , abnormal
retinal pigmented epithelium melanosome absent , abnormal
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 ZFA:0001094 whole organism whole organism has fewer parts of type melanocyte , abnormal
whole organism semi-viable , abnormal
whole organism lacks all parts of type melanocyte , abnormal
whole organism colorless , abnormal
whole organism decreased pigmentation , abnormal
whole organism degree of pigmentation , abnormal
whole organism lacks parts or has fewer parts of type melanocyte , abnormal
whole organism melanocyte absent , abnormal
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 ZFA:0001162 anal fin anal fin lacks all parts of type melanocyte , abnormal
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 ZFA:0001463 melanophore stripe melanophore stripe absent , abnormal
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 ZFA:0005221 dorsal larval melanophore stripe dorsal larval melanophore stripe iridophore mislocalised anteriorly , abnormal
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 ZFA:0005222 ventral larval melanophore stripe ventral larval melanophore stripe iridophore increased amount , abnormal
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 ZFA:0009090 pigment cell pigment cell quality , abnormal
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 ZFA:0009091 melanocyte melanocyte quality , abnormal
melanocyte unpigmented , abnormal
melanocyte decreased pigmentation , abnormal
melanocyte morphology , abnormal
melanocyte catechol oxidase activity disrupted , abnormal
melanocyte intensity , abnormal
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 ZFA:0009154 eye photoreceptor cell eye photoreceptor cell membrane immature , abnormal
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 ZFA:0009199 iridophore iridophore irregular spatial pattern , abnormal
iridophore morphology , abnormal
iridophore spatial pattern , abnormal
iridophore quality , abnormal
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 ZFA:0009249 melanoblast melanoblast unpigmented , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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