ENSDARG00000040492


Danio rerio

Features
Gene ID: ENSDARG00000040492
  
Biological name :mthfd1b
  
Synonyms : methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1b / mthfd1b
  
Possible biological names infered from orthology : methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 / methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase / MTHFD1 / P11586 / Q922D8
  
Species: Danio rerio
  
Chr. number: 17
Strand: -1
Band:
Gene start: 49354343
Gene end: 49412313
  
Corresponding Affymetrix probe sets: Dr.7124.1.S1_at (Zebrafish Array)   NM_199529_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000126431
Ensembl peptide - ENSDARP00000126462
Ensembl peptide - ENSDARP00000020770
NCBI entrez gene - 260441     See in Manteia.
RefSeq - NM_199529
RefSeq Peptide - NP_955823
swissprot - K7DYA3
swissprot - F1QXP5
swissprot - K7DYD3
ZFIN ID - ZDB-GENE-020905-4
Ensembl - ENSDARG00000040492
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MTHFD1ENSGALG00000011797Gallus gallus
 MTHFD1ENSG00000100714Homo sapiens
 Mthfd1ENSMUSG00000021048Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
mthfd1a / methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1a, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase / Q922D8* / MTHFD1* / P11586* / methylenet...ENSDARG0000001826660
mthfd1l / methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like / Q3V3R1* / Q6UB35*ENSDARG0000004222156


Protein motifs (from Interpro)
Interpro ID Name
 IPR000559  Formate-tetrahydrofolate ligase, FTHFS
 IPR000672  Tetrahydrofolate dehydrogenase/cyclohydrolase
 IPR016040  NAD(P)-binding domain
 IPR020628  Formate-tetrahydrofolate ligase, FTHFS, conserved site
 IPR020630  Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
 IPR020631  Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
 IPR020867  Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0009113 purine nucleobase biosynthetic process IBA
 biological_processGO:0009257 10-formyltetrahydrofolate biosynthetic process IBA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004329 formate-tetrahydrofolate ligase activity IBA
 molecular_functionGO:0004477 methenyltetrahydrofolate cyclohydrolase activity IBA
 molecular_functionGO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity IEA
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
Metabolism of folate and pterines


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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