ENSGALG00000011797


Gallus gallus

Features
Gene ID: ENSGALG00000011797
  
Biological name :MTHFD1
  
Synonyms : C-1-tetrahydrofolate synthase, cytoplasmic / MTHFD1
  
Possible biological names infered from orthology : methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 / methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase / P11586 / Q922D8
  
Species: Gallus gallus
  
Chr. number: 5
Strand: -1
Band:
Gene start: 53003519
Gene end: 53041100
  
Corresponding Affymetrix probe sets: Gga.1080.1.S1_s_at (Chicken Array)   Gga.1080.2.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000019224
NCBI entrez gene - 423508     See in Manteia.
RefSeq - NM_001039303
RefSeq - XM_015287494
RefSeq Peptide - NP_001034392
swissprot - F1NMC3
Ensembl - ENSGALG00000011797
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mthfd1aENSDARG00000018266Danio rerio
 mthfd1bENSDARG00000040492Danio rerio
 MTHFD1ENSG00000100714Homo sapiens
 Mthfd1ENSMUSG00000021048Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MTHFD1L / methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like / Q3V3R1* / Q6UB35*ENSGALG0000001241260


Protein motifs (from Interpro)
Interpro ID Name
 IPR000559  Formate-tetrahydrofolate ligase, FTHFS
 IPR000672  Tetrahydrofolate dehydrogenase/cyclohydrolase
 IPR016040  NAD(P)-binding domain
 IPR020628  Formate-tetrahydrofolate ligase, FTHFS, conserved site
 IPR020630  Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
 IPR020631  Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
 IPR020867  Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001780 neutrophil homeostasis IEA
 biological_processGO:0001843 neural tube closure IEA
 biological_processGO:0006164 purine nucleotide biosynthetic process IEA
 biological_processGO:0006555 methionine metabolic process IEA
 biological_processGO:0006730 one-carbon metabolic process IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0009069 serine family amino acid metabolic process IEA
 biological_processGO:0009070 serine family amino acid biosynthetic process IEA
 biological_processGO:0009086 methionine biosynthetic process IEA
 biological_processGO:0009113 purine nucleobase biosynthetic process IBA
 biological_processGO:0009257 10-formyltetrahydrofolate biosynthetic process IEA
 biological_processGO:0019346 transsulfuration IEA
 biological_processGO:0035999 tetrahydrofolate interconversion IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0061053 somite development IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004329 formate-tetrahydrofolate ligase activity IBA
 molecular_functionGO:0004477 methenyltetrahydrofolate cyclohydrolase activity IBA
 molecular_functionGO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity IEA
 molecular_functionGO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity IBA
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
Metabolism of folate and pterines


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000011797 MTHFD1 / C-1-tetrahydrofolate synthase, cytoplasmic / Q922D8* / P11586* / methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1* / methylenetetrah...  / complex






 

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