ENSGALG00000012412


Gallus gallus

Features
Gene ID: ENSGALG00000012412
  
Biological name :MTHFD1L
  
Synonyms : methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like / MTHFD1L
  
Possible biological names infered from orthology : Q3V3R1 / Q6UB35
  
Species: Gallus gallus
  
Chr. number: 3
Strand: 1
Band:
Gene start: 48792857
Gene end: 48928383
  
Corresponding Affymetrix probe sets: GgaAffx.7876.1.S1_s_at (Chicken Array)   GgaAffx.7876.4.S1_s_at (Chicken Array)   GgaAffx.7876.7.S1_at (Chicken Array)   GgaAffx.7876.7.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000020258
Ensembl peptide - ENSGALP00000047384
NCBI entrez gene - 421633     See in Manteia.
RefSeq - XM_004935617
swissprot - A0A1D5P3X8
swissprot - F1NCS6
Ensembl - ENSGALG00000012412
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mthfd1lENSDARG00000042221Danio rerio
 Q6UB35ENSG00000120254Homo sapiens
 Q3V3R1ENSMUSG00000040675Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MTHFD1 / C-1-tetrahydrofolate synthase, cytoplasmic / Q922D8* / P11586* / methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1* / methylenetetrah...ENSGALG0000001179760


Protein motifs (from Interpro)
Interpro ID Name
 IPR000559  Formate-tetrahydrofolate ligase, FTHFS
 IPR000672  Tetrahydrofolate dehydrogenase/cyclohydrolase
 IPR016040  NAD(P)-binding domain
 IPR020628  Formate-tetrahydrofolate ligase, FTHFS, conserved site
 IPR020630  Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
 IPR020631  Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001843 neural tube closure IEA
 biological_processGO:0009113 purine nucleobase biosynthetic process IBA
 biological_processGO:0009257 10-formyltetrahydrofolate biosynthetic process IBA
 biological_processGO:0048702 embryonic neurocranium morphogenesis IEA
 biological_processGO:0048703 embryonic viscerocranium morphogenesis IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005739 mitochondrion IEA
 molecular_functionGO:0004329 formate-tetrahydrofolate ligase activity IEA
 molecular_functionGO:0004477 methenyltetrahydrofolate cyclohydrolase activity IBA
 molecular_functionGO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity IBA
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
Metabolism of folate and pterines


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000012412 MTHFD1L / methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like / Q3V3R1* / Q6UB35*  / complex






 

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