ENSDARG00000042221


Danio rerio

Features
Gene ID: ENSDARG00000042221
  
Biological name :mthfd1l
  
Synonyms : methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like / mthfd1l
  
Possible biological names infered from orthology : Q3V3R1 / Q6UB35
  
Species: Danio rerio
  
Chr. number: 20
Strand: -1
Band:
Gene start: 26478197
Gene end: 26532167
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000061913
Ensembl peptide - ENSDARP00000118299
Ensembl peptide - ENSDARP00000122040
Ensembl peptide - ENSDARP00000154669
NCBI entrez gene - 100034522     See in Manteia.
RefSeq - NM_001242996
RefSeq - XM_005160551
RefSeq - XM_005160552
RefSeq Peptide - NP_001229925
swissprot - Q5PNN3
swissprot - Q5PNN5
swissprot - F1QQ79
ZFIN ID - ZDB-GENE-041001-133
Ensembl - ENSDARG00000042221
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MTHFD1LENSGALG00000012412Gallus gallus
 Q6UB35ENSG00000120254Homo sapiens
 Q3V3R1ENSMUSG00000040675Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
mthfd1b / methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1b / Q922D8* / MTHFD1* / P11586* / methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate syn...ENSDARG0000004049254
mthfd1a / methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1a, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase / Q922D8* / MTHFD1* / P11586* / methylenet...ENSDARG0000001826637


Protein motifs (from Interpro)
Interpro ID Name
 IPR000559  Formate-tetrahydrofolate ligase, FTHFS
 IPR000672  Tetrahydrofolate dehydrogenase/cyclohydrolase
 IPR016040  NAD(P)-binding domain
 IPR020628  Formate-tetrahydrofolate ligase, FTHFS, conserved site
 IPR020630  Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
 IPR020631  Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0009113 purine nucleobase biosynthetic process IBA
 biological_processGO:0009257 10-formyltetrahydrofolate biosynthetic process IBA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0004329 formate-tetrahydrofolate ligase activity IBA
 molecular_functionGO:0004477 methenyltetrahydrofolate cyclohydrolase activity IBA
 molecular_functionGO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity IBA
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
Metabolism of folate and pterines


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000042221 mthfd1l / methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like / Q3V3R1* / Q6UB35*  / complex






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr