ENSDARG00000044216


Danio rerio

Features
Gene ID: ENSDARG00000044216
  
Biological name :fto
  
Synonyms : fat mass and obesity associated / fto
  
Possible biological names infered from orthology : Alpha-ketoglutarate-dependent dioxygenase FTO / FTO, alpha-ketoglutarate dependent dioxygenase / Q8BGW1 / Q9C0B1
  
Species: Danio rerio
  
Chr. number: 7
Strand: -1
Band:
Gene start: 36110972
Gene end: 36358735
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000145984
Ensembl peptide - ENSDARP00000064912
Ensembl peptide - ENSDARP00000107656
NCBI entrez gene - 553363     See in Manteia.
RefSeq - XM_009303351
RefSeq - XM_021471999
RefSeq - XM_001345874
RefSeq - XM_021471998
swissprot - F1R5T4
swissprot - E7F9A2
ZFIN ID - ZDB-GENE-061108-1
Ensembl - ENSDARG00000044216
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FTOENSGALG00000041036Gallus gallus
 FTOENSG00000140718Homo sapiens
 FtoENSMUSG00000055932Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR024366  Alpha-ketoglutarate-dependent dioxygenase FTO, C-terminal
 IPR024367  Alpha-ketoglutarate-dependent dioxygenase FTO, catalytic domain
 IPR027450  Alpha-ketoglutarate-dependent dioxygenase AlkB-like
 IPR032868  Alpha-ketoglutarate-dependent dioxygenase FTO


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006307 DNA dealkylation involved in DNA repair IEA
 biological_processGO:0035552 oxidative single-stranded DNA demethylation IEA
 biological_processGO:0035553 oxidative single-stranded RNA demethylation IEA
 biological_processGO:0040014 regulation of multicellular organism growth IEA
 biological_processGO:0042245 RNA repair IEA
 biological_processGO:0043009 chordate embryonic development IMP
 biological_processGO:0060271 cilium assembly IMP
 biological_processGO:0060972 left/right pattern formation IMP
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IMP
 molecular_functionGO:0035515 oxidative RNA demethylase activity IEA
 molecular_functionGO:0035516 oxidative DNA demethylase activity IEA


Pathways (from Reactome)
Pathway description
Reversal of alkylation damage by DNA dioxygenases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000001 Kupffer s vesicle Kupffers vesicle decreased functionality , abnormal
Kupffers vesicle cilium decreased length , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
eye decreased distance eye , abnormal
Show

 ZFA:0000130 olfactory pit olfactory pit cilium decreased amount , abnormal
Show

 ZFA:0000150 pronephric duct pronephric duct cilium disorganized , abnormal
Show

 ZFA:0000155 somite somite decreased size , abnormal
Show

 ZFA:0001094 whole organism whole organism anterior-posterior axis curved , abnormal
whole organism dorsal-ventral axis shortened , abnormal
Show

 ZFA:0001114 head head decreased size , abnormal
Show

 ZFA:0001135 neural tube neural tube cilium disorganized , abnormal
Show

 ZFA:0001306 pharyngeal arch pharyngeal arch decreased width , abnormal
Show

 ZFA:0001458 cranial cartilage cranial cartilage decreased size , abnormal
Show

 ZFA:0001558 pronephric tubule pronephric tubule dilated , abnormal
Show

 ZFA:0009091 melanocyte melanocyte mislocalised , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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