ENSMUSG00000055932


Mus musculus

Features
Gene ID: ENSMUSG00000055932
  
Biological name :Fto
  
Synonyms : Alpha-ketoglutarate-dependent dioxygenase FTO / Fto / Q8BGW1
  
Possible biological names infered from orthology : FTO, alpha-ketoglutarate dependent dioxygenase / Q9C0B1
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: C4
Gene start: 91313525
Gene end: 91668439
  
Corresponding Affymetrix probe sets: 10573893 (MoGene1.0st)   1430829_s_at (Mouse Genome 430 2.0 Array)   1448223_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000147548
Ensembl peptide - ENSMUSP00000147603
Ensembl peptide - ENSMUSP00000147563
Ensembl peptide - ENSMUSP00000068380
Ensembl peptide - ENSMUSP00000123142
Ensembl peptide - ENSMUSP00000127680
NCBI entrez gene - 26383     See in Manteia.
MGI - MGI:1347093
RefSeq - NM_011936
RefSeq Peptide - NP_036066
swissprot - E9Q1E4
swissprot - D3Z127
swissprot - Q8BGW1
Ensembl - ENSMUSG00000055932
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ftoENSDARG00000044216Danio rerio
 FTOENSGALG00000041036Gallus gallus
 FTOENSG00000140718Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR024366  Alpha-ketoglutarate-dependent dioxygenase FTO, C-terminal
 IPR024367  Alpha-ketoglutarate-dependent dioxygenase FTO, catalytic domain
 IPR032868  Alpha-ketoglutarate-dependent dioxygenase FTO
 IPR037151  Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001659 temperature homeostasis IMP
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006307 DNA dealkylation involved in DNA repair IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0010883 regulation of lipid storage ISO
 biological_processGO:0035552 oxidative single-stranded DNA demethylation IEA
 biological_processGO:0035553 oxidative single-stranded RNA demethylation IEA
 biological_processGO:0040014 regulation of multicellular organism growth IEA
 biological_processGO:0042245 RNA repair IEA
 biological_processGO:0044065 regulation of respiratory system process IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0060612 adipose tissue development IMP
 biological_processGO:0070350 regulation of white fat cell proliferation IMP
 biological_processGO:0070989 oxidative demethylation IDA
 biological_processGO:0080111 DNA demethylation IDA
 biological_processGO:0090335 regulation of brown fat cell differentiation ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0016607 nuclear speck ISO
 molecular_functionGO:0008198 ferrous iron binding ISS
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0035515 oxidative RNA demethylase activity IEA
 molecular_functionGO:0035516 oxidative DNA demethylase activity IEA
 molecular_functionGO:0043734 DNA-N1-methyladenine dioxygenase activity ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051213 dioxygenase activity IEA
 molecular_functionGO:1990931 RNA N6-methyladenosine dioxygenase activity ISO


Pathways (from Reactome)
Pathway description
Reversal of alkylation damage by DNA dioxygenases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000003 abnormal adipose tissue morphology "structural anomaly of the connective tissue composed of fat cells enmeshed in areolar tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ftotm1Urt/Ftotm1Urt,Lepob/Lepob
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Ftotm1.3Pzg/Ftotm1.3Pzg
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Ftotm1.2Pzg/Ftotm1.2Pzg
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Ftotm1.1Pzg/Ftotm1.1Pzg,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0000183 decreased circulating LDL cholesterol level "less than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ftotm1a(EUCOMM)Wtsi/Ftotm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Ftotm1a(EUCOMM)Wtsi/Wtsi

 MP:0001194 dermatitis "inflammation of the skin" [J:65146]
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Allelic Composition: Ftotm1.3Pzg/Ftotm1.3Pzg
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Ftotm1.2Pzg/Ftotm1.2Pzg
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Gdi1tm1Ytk/Gdi1tm1Ytk
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * C57BL/6 * DBA/2)

Allelic Composition: Ftotm1.3Pzg/Ftotm1.3Pzg
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Ftotm1.2Pzg/Ftotm1.2Pzg
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Ftotm1.1Pzg/Ftotm1.1Pzg,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * SJL

Allelic Composition: Ftotm1Urt/Ftotm1Urt,Lepob/Lepob
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Ftotm1Urt/Ftotm1Urt,Lepob/Lepob
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Gdi1tm1Ytk/Gdi1tm1Ytk
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * C57BL/6 * DBA/2)

Allelic Composition: FtoI367F/FtoI367F
Genetic Background: involves: C3H/HeH * C57BL/6J

Allelic Composition: FtoI367F/Fto+
Genetic Background: involves: C3H/HeH * C57BL/6J

Allelic Composition: Ftotm1.3Pzg/Ftotm1.3Pzg
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Ftotm1.2Pzg/Ftotm1.2Pzg
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Ftotm1.1Rdc/Ftotm1.1Rdc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Ftotm1.1Rdc/Ftotm1.1Rdc,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Ftotm1.2Rdc/Ftotm1.2Rdc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Ftotm1a(EUCOMM)Wtsi/Ftotm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Ftotm1a(EUCOMM)Wtsi/Wtsi

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Ftotm1a(EUCOMM)Wtsi/Ftotm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Ftotm1a(EUCOMM)Wtsi/Wtsi

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Gdi1tm1Ytk/Gdi1tm1Ytk
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * C57BL/6 * DBA/2)

Allelic Composition: Ftotm1Urt/Ftotm1Urt,Lepob/Lepob
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001431 abnormal eating behavior "inability to consume or atypical consumption pattern" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:19212]
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Allelic Composition: Dmbt1tm2Qaa/Dmbt1tm2Qaa,Tg(ATP6V1B1-cre)45Rnel/0
Genetic Background: involves: C57BL/6 * C57BL/6J * CBA

Allelic Composition: Ftotm1.2Pzg/Ftotm1.2Pzg
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Ftotm1.1Pzg/Ftotm1.1Pzg,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0001433 polyphagia "eating to excess" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gdi1tm1Ytk/Gdi1tm1Ytk
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * C57BL/6 * DBA/2)

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: FtoI367F/FtoI367F
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0001556 increased circulating HDL cholesterol level "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]
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Allelic Composition: FtoI367F/FtoI367F
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gdi1tm1Ytk/Gdi1tm1Ytk
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * C57BL/6 * DBA/2)

Allelic Composition: Ftotm1.3Pzg/Ftotm1.3Pzg
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Ftotm1.2Pzg/Ftotm1.2Pzg
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Ftotm1.1Pzg/Ftotm1.1Pzg,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ftotm1.1Rdc/Ftotm1.1Rdc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ftotm1Urt/Ftotm1Urt,Lepob/Lepob
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002712 increased circulating glucagon level "greater than normal blood concentration of this peptide hormone" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: FtoI367F/FtoI367F
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: FtoI367F/FtoI367F
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0002942 decreased circulating alanine transaminase level "decreased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ftotm1a(EUCOMM)Wtsi/Ftotm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Ftotm1a(EUCOMM)Wtsi/Wtsi

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Ftotm1Urt/Ftotm1Urt,Lepob/Lepob
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: FtoI367F/FtoI367F
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Gdi1tm1Ytk/Gdi1tm1Ytk
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * C57BL/6 * DBA/2)

Allelic Composition: Ftotm1.3Pzg/Ftotm1.3Pzg
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Ftotm1.2Pzg/Ftotm1.2Pzg
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Ftotm1.1Pzg/Ftotm1.1Pzg,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * SJL

Allelic Composition: Ftotm1.1Rdc/Ftotm1.1Rdc,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Ftotm1.2Rdc/Ftotm1.2Rdc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * SJL

 MP:0004151 hypoferremia "less than the normal concentration of this metallic element in the blood" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Ftotm1a(EUCOMM)Wtsi/Ftotm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Ftotm1a(EUCOMM)Wtsi/Wtsi

 MP:0004701 decreased circulating insulin-like growth factor I level "reduced blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ftotm1.3Pzg/Ftotm1.3Pzg
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Ftotm1.2Pzg/Ftotm1.2Pzg
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Ftotm1.1Pzg/Ftotm1.1Pzg,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0004889 increased energy expenditure "increase in the number of calories used per unit time or decrease in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gdi1tm1Ytk/Gdi1tm1Ytk
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * C57BL/6 * DBA/2)

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ftotm1.3Pzg/Ftotm1.3Pzg
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Ftotm1.2Pzg/Ftotm1.2Pzg
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: FtoI367F/FtoI367F
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0005266 abnormal metabolism "anomalous chemical and physical changes occurring in tissue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: FtoI367F/FtoI367F
Genetic Background: involves: C3H/HeH * C57BL/6J

Allelic Composition: FtoI367F/Fto+
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0005288 abnormal oxygen consumption "deviation from the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ftotm1.3Pzg/Ftotm1.3Pzg
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Ftotm1.2Pzg/Ftotm1.2Pzg
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Ftotm1.1Pzg/Ftotm1.1Pzg,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gdi1tm1Ytk/Gdi1tm1Ytk
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * C57BL/6 * DBA/2)

Allelic Composition: FtoI367F/FtoI367F
Genetic Background: involves: C3H/HeH * C57BL/6J

Allelic Composition: FtoI367F/Fto+
Genetic Background: involves: C3H/HeH * C57BL/6J

Allelic Composition: Ftotm1.2Rdc/Ftotm1.2Rdc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * SJL

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ftotm1.2Rdc/Ftotm1.2Rdc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * SJL

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ftotm1Urt/Ftotm1Urt,Lepob/Lepob
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005418 abnormal circulating hormone level "anomalous blood concentration of any of the chemical substances that have specific regulatory effects on the activity of a certain organ or organs; originally applied to substances secreted by various endocrine glands and transported in the bloodstream to the target organs, it is sometimes extended to include substances that are not produced by the endocrine glands but that have similar effects" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gdi1tm1Ytk/Gdi1tm1Ytk
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * C57BL/6 * DBA/2)

 MP:0005458 increased percent body fat "more fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ftotm1Urt/Ftotm1Urt,Lepob/Lepob
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005459 decreased percent body fat "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: FtoI367F/FtoI367F
Genetic Background: involves: C3H/HeH * C57BL/6J

Allelic Composition: FtoI367F/Fto+
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: FtoI367F/FtoI367F
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0005571 decreased lactate dehydrogenase level "less than the normal concentration of this enzyme, which catalyzes the interconversion of lactate and pyruvate" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ftotm1a(EUCOMM)Wtsi/Ftotm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Ftotm1a(EUCOMM)Wtsi/Wtsi

 MP:0005632 decreased circulating aspartate transaminase level "less than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Ftotm1a(EUCOMM)Wtsi/Ftotm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Ftotm1a(EUCOMM)Wtsi/Wtsi

 MP:0005658 susceptibility to diet-induced obesity "more likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Ftotm1.3Pzg/Ftotm1.3Pzg
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Ftotm1.2Pzg/Ftotm1.2Pzg
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Gdi1tm1Ytk/Gdi1tm1Ytk
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * C57BL/6 * DBA/2)

Allelic Composition: Ftotm1Urt/Fto+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005662 increased circulating adrenaline level "greater than the normal concentration in the blood of this catacholamine hormone that stimulates the adrenergic receptors and that causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Gdi1tm1Ytk/Gdi1tm1Ytk
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * C57BL/6 * DBA/2)

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Gdi1tm1Ytk/Gdi1tm1Ytk
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * C57BL/6 * DBA/2)

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: FtoI367F/FtoI367F
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0006094 adipocyte hypertrophy "increase in the size of fat cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:90802]
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Allelic Composition: Ftotm1Urt/Ftotm1Urt,Lepob/Lepob
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008962 abnormal carbon dioxide production "deviation from the normal rate at which carbon dioxide leaves the blood and enters the alveolar gas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ftotm1.3Pzg/Ftotm1.3Pzg
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Ftotm1.2Pzg/Ftotm1.2Pzg
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Ftotm1.1Pzg/Ftotm1.1Pzg,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0008963 increased carbon dioxide production "increase in the rate at which carbon dioxide leaves the blood and enters the alveolar gas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gdi1tm1Ytk/Gdi1tm1Ytk
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * C57BL/6 * DBA/2)

Allelic Composition: FtoI367F/FtoI367F
Genetic Background: involves: C3H/HeH * C57BL/6J

Allelic Composition: FtoI367F/Fto+
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0008964 decreased carbon dioxide production "reduction in the rate at which carbon dioxide leaves the blood and enters the alveolar gas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: FtoI367F/FtoI367F
Genetic Background: involves: C3H/HeH * C57BL/6J

Allelic Composition: Ftotm1.1Rdc/Ftotm1.1Rdc,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0008965 increased basal metabolism "increase in heat production of an organism at the lowest level of cell chemistry in an inactive, awake, and fasting state" [MESH:E01.370.374.750.100]
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Allelic Composition: Gdi1tm1Ytk/Gdi1tm1Ytk
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * C57BL/6 * DBA/2)

 MP:0009133 decreased white fat cell size "reduction in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gdi1tm1Ytk/Gdi1tm1Ytk
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * C57BL/6 * DBA/2)

 MP:0009171 enlarged pancreatic islets "increase in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
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Allelic Composition: Ftotm1Urt/Ftotm1Urt,Lepob/Lepob
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009283 decreased gonadal fat pad weight "less than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gdi1tm1Ytk/Gdi1tm1Ytk
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * C57BL/6 * DBA/2)

 MP:0009285 increased gonadal fat pad weight "greater than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ftotm1Urt/Ftotm1Urt,Lepob/Lepob
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009292 increased inguinal fat pad weight 
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Allelic Composition: Ftotm1Urt/Ftotm1Urt,Lepob/Lepob
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009294 increased interscapular fat pad weight 
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Allelic Composition: Ftotm1Urt/Ftotm1Urt,Lepob/Lepob
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ftotm1.3Pzg/Ftotm1.3Pzg
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Ftotm1.2Pzg/Ftotm1.2Pzg
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Ftotm1.1Rdc/Ftotm1.1Rdc,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gdi1tm1Ytk/Gdi1tm1Ytk
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * C57BL/6 * DBA/2)

Allelic Composition: FtoI367F/FtoI367F
Genetic Background: involves: C3H/HeH * C57BL/6J

Allelic Composition: FtoI367F/Fto+
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0010378 increased respiratory quotient "increase in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: FtoI367F/FtoI367F
Genetic Background: involves: C3H/HeH * C57BL/6J

Allelic Composition: FtoI367F/Fto+
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0010379 decreased respiratory quotient "reduction in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ftotm1.1Rdc/Ftotm1.1Rdc,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Ftotm1.2Rdc/Ftotm1.2Rdc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * SJL

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Gdi1tm1Ytk/Gdi1tm1Ytk
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * C57BL/6 * DBA/2)

Allelic Composition: Ftotm1.3Pzg/Ftotm1.3Pzg
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Ftotm1.2Pzg/Ftotm1.2Pzg
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Ftotm1.2Rdc/Ftotm1.2Rdc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * SJL

 MP:0011478 abnormal urine catecholamine level "any anomaly in the urinary amount of catecholamines, including adrenaline, noradrenaline and L-dopamine; catecholamines are act as hormones or neurotransmitters and are derived from the amino acid tyrosine" [MGI:csmith]
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Allelic Composition: FtoI367F/FtoI367F
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Ftotm1.2Rdc/Ftotm1.2Rdc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * SJL

 MP:0011940 decreased food intake "reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Ftotm1.1Rdc/Ftotm1.1Rdc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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