ENSDARG00000052696


Danio rerio

Features
Gene ID: ENSDARG00000052696
  
Biological name :bdh2
  
Synonyms : 3-hydroxybutyrate dehydrogenase, type 2 / bdh2 / Q561X9
  
Possible biological names infered from orthology : 3-hydroxybutyrate dehydrogenase 2 / Q8JZV9 / Q9BUT1
  
Species: Danio rerio
  
Chr. number: 1
Strand: -1
Band:
Gene start: 43714149
Gene end: 43727576
  
Corresponding Affymetrix probe sets: Dr.15584.1.S1_at (Zebrafish Array)   NM_001017809_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000146933
Ensembl peptide - ENSDARP00000069085
Ensembl peptide - ENSDARP00000117736
Ensembl peptide - ENSDARP00000119021
NCBI entrez gene - 550507     See in Manteia.
RefSeq - NM_001017809
RefSeq - XM_005160067
RefSeq Peptide - NP_001017809
swissprot - Q561X9
swissprot - Z4YIQ5
swissprot - B2GSA5
ZFIN ID - ZDB-GENE-050417-343
Ensembl - ENSDARG00000052696
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BDH2ENSGALG00000012338Gallus gallus
 BDH2ENSG00000164039Homo sapiens
 Bdh2ENSMUSG00000028167Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
zgc:113054ENSDARG0000005348335
zgc:101858ENSDARG0000003512931
hsd17b8 / hydroxysteroid (17-beta) dehydrogenase 8 / H2-Ke6* / P50171* / Q92506* / H2-K region expressed gene 6*ENSDARG0000000116931
dhrs4 / dehydrogenase/reductase (SDR family) member 4 / DHRS2* / Q13268* / Q99LB2* / Q6PKH6* / Q9BTZ2* / DHRS4L2* / dehydrogenase/reductase 2* / dehydrogenase/reductase 4* / dehydrogenase/r...ENSDARG0000002113529
hpgd / 15-hydroxyprostaglandin dehydrogenase / P15428* / Q8VCC1* / 15-hydroxyprostaglandin dehydrogenase [NAD(+)] *ENSDARG0000001201627
dcxr / dicarbonyl/L-xylulose reductase / Cbr2* / Q91X52* / P08074* / Q7Z4W1* / L-xylulose reductase * / Carbonyl reductase [NADPH] 2 * / dicarbonyl and L-xylulose reductase*ENSDARG0000007927127
hsd17b14 / hydroxysteroid (17-beta) dehydrogenase 14 / Q9BPX1*ENSDARG0000005484227
hsd17b10 / hydroxysteroid (17-beta) dehydrogenase 10 / Q99714*ENSDARG0000001778127
cbr4 / carbonyl reductase 4 / Q8N4T8* / Q91VT4* / Carbonyl reductase family member 4 *ENSDARG0000000907426
zgc:56585ENSDARG0000002623626


Protein motifs (from Interpro)
Interpro ID Name
 IPR002347  Short-chain dehydrogenase/reductase SDR
 IPR016040  NAD(P)-binding domain
 IPR020904  Short-chain dehydrogenase/reductase, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0019290 siderophore biosynthetic process ISS
 biological_processGO:0042168 heme metabolic process IMP
 biological_processGO:0042541 hemoglobin biosynthetic process IMP
 biological_processGO:0043249 erythrocyte maturation IMP
 biological_processGO:0055072 iron ion homeostasis ISS
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0003858 3-hydroxybutyrate dehydrogenase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor ISS


Pathways (from Reactome)
Pathway description
Synthesis of Ketone Bodies


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0005237 erythroblast erythroblast nucleus increased size , abnormal
erythroblast mitophagy premature , abnormal
erythroblast mitophagy increased occurrence , abnormal
erythroblast nucleus size , ameliorated
erythroblast mitochondrion decreased amount , abnormal
erythroblast lysosome has extra parts of type erythroblast mitochondrion, abnormal
erythroblast mitophagy occurrence , ameliorated
erythroblast mitochondrion amount , ameliorated
Show

 ZFA:0009256 nucleate erythrocyte nucleate erythrocyte hemoglobin complex decreased amount , abnormal
nucleate erythrocyte increased amount , abnormal
nucleate erythrocyte hemoglobin biosynthetic process occurrence , ameliorated
nucleate erythrocyte hemoglobin biosynthetic process decreased occurrence , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000052696 bdh2 / Q561X9 / 3-hydroxybutyrate dehydrogenase, type 2 / Q8JZV9* / Q9BUT1* / 3-hydroxybutyrate dehydrogenase 2*  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr