ENSDARG00000053068


Danio rerio

Features
Gene ID: ENSDARG00000053068
  
Biological name :cyp8b1
  
Synonyms : cyp8b1 / cytochrome P450, family 8, subfamily B, polypeptide 1
  
Possible biological names infered from orthology : cytochrome P450 family 8 subfamily B member 1 / Q9UNU6
  
Species: Danio rerio
  
Chr. number: 2
Strand: -1
Band:
Gene start: 3435888
Gene end: 3437862
  
Corresponding Affymetrix probe sets: Dr.20589.1.S1_at (Zebrafish Array)   Dr.4242.1.A1_at (Zebrafish Array)   NM_001003736_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000091773
NCBI entrez gene - 445281     See in Manteia.
RefSeq - NM_001003736
RefSeq Peptide - NP_001003736
swissprot - F1QIJ9
ZFIN ID - ZDB-GENE-040808-53
Ensembl - ENSDARG00000053068
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CYP8B1ENSGALG00000033511Gallus gallus
 CYP8B1ENSG00000180432Homo sapiens
 Cyp8b1ENSMUSG00000050445Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
cyp8b3 / cytochrome P450, family 8, subfamily B, polypeptide 3 / CYP8B1* / Q9UNU6* / cytochrome P450 family 8 subfamily B member 1*ENSDARG0000009755990
cyp8b2 / cytochrome P450, family 8, subfamily B, polypeptide 2 / CYP8B1* / Q9UNU6* / cytochrome P450 family 8 subfamily B member 1*ENSDARG0000009755690
ptgis / F1RE08 / prostaglandin I2 (prostacyclin) synthase / O35074* / Q16647* / prostaglandin I2 synthase*ENSDARG0000006009438
cyp7a1 / cytochrome P450, family 7, subfamily A, polypeptide 1 / P22680* / Q64505* / Cholesterol 7-alpha-monooxygenase * / cytochrome P450 family 7 subfamily A member 1*ENSDARG0000006901834
CR354540.1ENSDARG0000000405132
cyp7b1 / cytochrome P450, family 7, subfamily B, polypeptide 1 / O75881* / Q60991* / 25-hydroxycholesterol 7-alpha-hydroxylase * / cytochrome P450 family 7 subfamily B member 1*ENSDARG0000000885832
cyp39a1 / cytochrome P450, family 39, subfamily A, polypeptide 1 / Q9NYL5* / cytochrome P450 family 39 subfamily A member 1*ENSDARG0000001798221


Protein motifs (from Interpro)
Interpro ID Name
 IPR001128  Cytochrome P450
 IPR002403  Cytochrome P450, E-class, group IV
 IPR017972  Cytochrome P450, conserved site
 IPR024204  Cytochrome P450, cholesterol 7-alpha-monooxygenase-type
 IPR030686  Cytochrome P450 8B1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0008397 sterol 12-alpha-hydroxylase activity IBA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
Synthesis of bile acids and bile salts via 24-hydroxycholesterol
Synthesis of bile acids and bile salts via 27-hydroxycholesterol
Nicotinamide salvaging
Eicosanoids
Sterols are 12-hydroxylated by CYP8B1
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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