ENSDARG00000069018


Danio rerio

Features
Gene ID: ENSDARG00000069018
  
Biological name :cyp7a1
  
Synonyms : cyp7a1 / cytochrome P450, family 7, subfamily A, polypeptide 1
  
Possible biological names infered from orthology : Cholesterol 7-alpha-monooxygenase / cytochrome P450 family 7 subfamily A member 1 / P22680 / Q64505
  
Species: Danio rerio
  
Chr. number: 2
Strand: -1
Band:
Gene start: 22150134
Gene end: 22152797
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000113850
NCBI entrez gene - 394148     See in Manteia.
RefSeq - NM_201173
RefSeq Peptide - NP_957467
swissprot - F1QU76
ZFIN ID - ZDB-GENE-040426-1296
Ensembl - ENSDARG00000069018
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CYP7A1ENSGALG00000041222Gallus gallus
 CYP7A1ENSG00000167910Homo sapiens
 Cyp7a1ENSMUSG00000028240Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CR354540.1ENSDARG0000000405143
cyp7b1 / cytochrome P450, family 7, subfamily B, polypeptide 1 / O75881* / Q60991* / 25-hydroxycholesterol 7-alpha-hydroxylase * / cytochrome P450 family 7 subfamily B member 1*ENSDARG0000000885838
cyp8b1 / cytochrome P450, family 8, subfamily B, polypeptide 1 / Q9UNU6* / cytochrome P450 family 8 subfamily B member 1*ENSDARG0000005306835
cyp8b2 / cytochrome P450, family 8, subfamily B, polypeptide 2 / CYP8B1* / Q9UNU6* / cytochrome P450 family 8 subfamily B member 1*ENSDARG0000009755635
cyp8b3 / cytochrome P450, family 8, subfamily B, polypeptide 3 / CYP8B1* / Q9UNU6* / cytochrome P450 family 8 subfamily B member 1*ENSDARG0000009755935
ptgis / F1RE08 / prostaglandin I2 (prostacyclin) synthase / O35074* / Q16647* / prostaglandin I2 synthase*ENSDARG0000006009430
cyp39a1 / cytochrome P450, family 39, subfamily A, polypeptide 1 / Q9NYL5* / cytochrome P450 family 39 subfamily A member 1*ENSDARG0000001798220


Protein motifs (from Interpro)
Interpro ID Name
 IPR001128  Cytochrome P450
 IPR002403  Cytochrome P450, E-class, group IV
 IPR017972  Cytochrome P450, conserved site
 IPR024204  Cytochrome P450, cholesterol 7-alpha-monooxygenase-type
 IPR030681  Cholesterol 7-alpha-monooxygenase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006699 bile acid biosynthetic process IEA
 biological_processGO:0006707 cholesterol catabolic process IEA
 biological_processGO:0008203 cholesterol metabolic process IEA
 biological_processGO:0042632 cholesterol homeostasis IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0071333 cellular response to glucose stimulus IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0008123 cholesterol 7-alpha-monooxygenase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Synthesis of bile acids and bile salts
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
Synthesis of bile acids and bile salts via 27-hydroxycholesterol
Endogenous sterols


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr