ENSMUSG00000028240


Mus musculus

Features
Gene ID: ENSMUSG00000028240
  
Biological name :Cyp7a1
  
Synonyms : Cholesterol 7-alpha-monooxygenase / Cyp7a1 / Q64505
  
Possible biological names infered from orthology : cytochrome P450 family 7 subfamily A member 1 / P22680
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: A1
Gene start: 6265612
Gene end: 6275633
  
Corresponding Affymetrix probe sets: 10511375 (MoGene1.0st)   1422100_at (Mouse Genome 430 2.0 Array)   1438743_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029905
NCBI entrez gene - 13122     See in Manteia.
MGI - MGI:106091
RefSeq - XM_006537604
RefSeq - NM_007824
RefSeq - XM_006537603
RefSeq Peptide - NP_031850
swissprot - Q64505
Ensembl - ENSMUSG00000028240
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cyp7a1ENSDARG00000069018Danio rerio
 CYP7A1ENSGALG00000041222Gallus gallus
 CYP7A1ENSG00000167910Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cyp7b1 / Q60991 / 25-hydroxycholesterol 7-alpha-hydroxylase / O75881* / cytochrome P450 family 7 subfamily B member 1*ENSMUSG0000003951938
Cyp8b1 / cytochrome P450 family 8 subfamily B member 1 / Q9UNU6*ENSMUSG0000005044533
Ptgis / O35074 / prostaglandin I2 (prostacyclin) synthase / Q16647* / prostaglandin I2 synthase*ENSMUSG0000001796931
Q9JKJ9 / Cyp39a1 / 24-hydroxycholesterol 7-alpha-hydroxylase / Q9NYL5* / cytochrome P450 family 39 subfamily A member 1*ENSMUSG0000002396321


Protein motifs (from Interpro)
Interpro ID Name
 IPR001128  Cytochrome P450
 IPR002403  Cytochrome P450, E-class, group IV
 IPR017972  Cytochrome P450, conserved site
 IPR024204  Cytochrome P450, cholesterol 7-alpha-monooxygenase-type
 IPR030681  Cholesterol 7-alpha-monooxygenase
 IPR036396  Cytochrome P450 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006699 bile acid biosynthetic process ISO
 biological_processGO:0006707 cholesterol catabolic process ISS
 biological_processGO:0008202 steroid metabolic process IEA
 biological_processGO:0008203 cholesterol metabolic process IEA
 biological_processGO:0042632 cholesterol homeostasis ISS
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0070857 regulation of bile acid biosynthetic process IEA
 biological_processGO:0070859 positive regulation of bile acid biosynthetic process TAS
 biological_processGO:0071333 cellular response to glucose stimulus ISO
 biological_processGO:0071397 cellular response to cholesterol IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031090 organelle membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISS
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0008123 cholesterol 7-alpha-monooxygenase activity IDA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Synthesis of bile acids and bile salts
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
Synthesis of bile acids and bile salts via 27-hydroxycholesterol
Endogenous sterols


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
Show

Allelic Composition: Catsper1tm1Clph/Catsper1tm1Clph
Genetic Background: involves: 129S4/SvJae

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Catsper1tm1Clph/Catsper1tm1Clph
Genetic Background: involves: 129S4/SvJae

 MP:0001191 abnormal skin condition "anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Catsper1tm1Clph/Catsper1tm1Clph
Genetic Background: involves: 129S4/SvJae

 MP:0001195 flaky skin "shedding scales on the skin " [J:56641]
Show

Allelic Composition: Catsper1tm1Clph/Catsper1tm1Clph
Genetic Background: involves: 129S4/SvJae

 MP:0001197 oily skin 
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Allelic Composition: Catsper1tm1Clph/Catsper1tm1Clph
Genetic Background: involves: 129S4/SvJae

 MP:0001231 abnormal basal cell layer morphology "structural anomaly of the deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Catsper1tm1Clph/Catsper1tm1Clph
Genetic Background: involves: 129S4/SvJae

 MP:0001238 thin epidermal spinous layer "reduced thickness of the stratum spinosum; the polyhedral cell layer" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:15108]
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Allelic Composition: Catsper1tm1Clph/Catsper1tm1Clph
Genetic Background: involves: 129S4/SvJae

 MP:0001239 abnormal granular layer morphology "structural or developmental anomaly of the layer of flattened cells containing basophilic granules of keratohyalin and lying just above the stratum spinosum (spiny layer) of the epidermis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Catsper1tm1Clph/Catsper1tm1Clph
Genetic Background: involves: 129S4/SvJae

 MP:0001242 hyperkeratosis "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]
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Allelic Composition: Catsper1tm1Clph/Catsper1tm1Clph
Genetic Background: involves: 129S4/SvJae

 MP:0001244 thin dermal layer "reduced thickness of the dermis" [J:65030]
Show

Allelic Composition: Catsper1tm1Clph/Catsper1tm1Clph
Genetic Background: involves: 129S4/SvJae

 MP:0001290 delayed eyelid opening "late average time for the first postnatal eye opening" [J:17792]
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Allelic Composition: Catsper1tm1Clph/Catsper1tm1Clph
Genetic Background: involves: 129S4/SvJae

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Catsper1tm1Clph/Catsper1tm1Clph
Genetic Background: involves: 129S4/SvJae

 MP:0001417 decreased exploration in new environment "less amount of time spent investigating a new location" [J:79870]
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Allelic Composition: Catsper1tm1Clph/Catsper1tm1Clph
Genetic Background: involves: 129S4/SvJae

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Catsper1tm1Clph/Catsper1tm1Clph
Genetic Background: involves: 129S4/SvJae

 MP:0002060 abnormal skin morphology "malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]
Show

Allelic Composition: Catsper1tm1Clph/Catsper1tm1Clph
Genetic Background: involves: 129S4/SvJae

 MP:0002090 abnormal vision "inability or decreased ability to see " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Catsper1tm1Clph/Catsper1tm1Clph
Genetic Background: involves: 129S4/SvJae

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Catsper1tm1Clph/Catsper1tm1Clph
Genetic Background: involves: 129S4/SvJae

 MP:0002647 decreased cholesterol absorption "reduced ability of the body to take in these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Catsper1tm1Clph/Catsper1tm1Clph
Genetic Background: involves: 129S4/SvJae

 MP:0002791 steatorrhea "passage of large amounts of fat in the feces due to the inability to digest and absorb it" [J:75167]
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Allelic Composition: Catsper1tm1Clph/Catsper1tm1Clph
Genetic Background: involves: 129S4/SvJae

 MP:0003849 greasy coat "fur is oily in appearance or texture" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Catsper1tm1Clph/Catsper1tm1Clph
Genetic Background: involves: 129S4/SvJae

 MP:0003853 dry skin "skin characterized by the lack of natural or normal moisture" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Catsper1tm1Clph/Catsper1tm1Clph
Genetic Background: involves: 129S4/SvJae

 MP:0004773 abnormal bile composition "any alteration in the chemical make up of the greenish-yellow fluid secreted by the liver; normally contains bile acids and salts such as sodium glycocholate and sodium taurocholate as well as cholesterol, biliverdin and bilirubin, mucus, fat, lecithin, and cells and cellular debris" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Catsper1tm1Clph/Catsper1tm1Clph
Genetic Background: involves: 129S4/SvJae

 MP:0004774 abnormal bile salt level "anomalous concentration of the steroid salts derived from cholesterol in the liver, produced as bile acids and secreted in the biliary sytem as bile salts; these play an important role in the digestion and absorption of fats" [MESH:D04.808.105, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Catsper1tm1Clph/Catsper1tm1Clph
Genetic Background: involves: 129S4/SvJae

 MP:0005365 abnormal bile salt homeostasis "anomalous regulation of the steroid salts derived from cholesterol in the liver and which play an important role in the digestion and absorption of fats" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:86154]
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Allelic Composition: Catsper1tm1Clph/Catsper1tm1Clph
Genetic Background: involves: 129S4/SvJae

 MP:0005401 abnormal fat-soluble vitamin level "anomalous concentration of any of the organic substances found in food that are necessary in trace amounts for normal metabolic function and which require the presence of lipids for assimilation in the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Catsper1tm1Clph/Catsper1tm1Clph
Genetic Background: involves: 129S4/SvJae

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
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Allelic Composition: Catsper1tm1Clph/Catsper1tm1Clph
Genetic Background: involves: 129S4/SvJae

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Catsper1tm1Clph/Catsper1tm1Clph
Genetic Background: involves: 129S4/SvJae

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Catsper1tm1Clph/Catsper1tm1Clph
Genetic Background: involves: 129S4/SvJae

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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