ENSMUSG00000017969


Mus musculus

Features
Gene ID: ENSMUSG00000017969
  
Biological name :Ptgis
  
Synonyms : O35074 / prostaglandin I2 (prostacyclin) synthase / Ptgis
  
Possible biological names infered from orthology : prostaglandin I2 synthase / Q16647
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: H3
Gene start: 167191805
Gene end: 167240604
  
Corresponding Affymetrix probe sets: 10489878 (MoGene1.0st)   1448816_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000018113
Ensembl peptide - ENSMUSP00000085357
NCBI entrez gene - 19223     See in Manteia.
MGI - MGI:1097156
RefSeq - NM_008968
RefSeq Peptide - NP_032994
swissprot - O35074
swissprot - Q8BXC0
Ensembl - ENSMUSG00000017969
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptgisENSDARG00000060094Danio rerio
 PTGISENSG00000124212Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cyp8b1 / cytochrome P450 family 8 subfamily B member 1 / Q9UNU6*ENSMUSG0000005044540
Cyp7a1 / Q64505 / Cholesterol 7-alpha-monooxygenase / P22680* / cytochrome P450 family 7 subfamily A member 1*ENSMUSG0000002824031
Cyp7b1 / Q60991 / 25-hydroxycholesterol 7-alpha-hydroxylase / O75881* / cytochrome P450 family 7 subfamily B member 1*ENSMUSG0000003951929
Q9JKJ9 / Cyp39a1 / 24-hydroxycholesterol 7-alpha-hydroxylase / Q9NYL5* / cytochrome P450 family 39 subfamily A member 1*ENSMUSG0000002396320


Protein motifs (from Interpro)
Interpro ID Name
 IPR001128  Cytochrome P450
 IPR002403  Cytochrome P450, E-class, group IV
 IPR024204  Cytochrome P450, cholesterol 7-alpha-monooxygenase-type
 IPR027286  Prostacyclin synthase
 IPR036396  Cytochrome P450 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001516 prostaglandin biosynthetic process IEA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006633 fatty acid biosynthetic process IEA
 biological_processGO:0006693 prostaglandin metabolic process IEA
 biological_processGO:0007566 embryo implantation IDA
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway IEA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0045019 negative regulation of nitric oxide biosynthetic process IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0046697 decidualization IDA
 biological_processGO:0050728 negative regulation of inflammatory response IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0071347 cellular response to interleukin-1 IEA
 biological_processGO:0071354 cellular response to interleukin-6 IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:0097190 apoptotic signaling pathway IEA
 biological_processGO:1900119 positive regulation of execution phase of apoptosis IEA
 cellular_componentGO:0005615 extracellular space ISS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005901 caveola IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0008116 prostaglandin-I synthase activity IEA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0016853 isomerase activity IEA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
Synthesis of bile acids and bile salts via 24-hydroxycholesterol
Synthesis of bile acids and bile salts via 27-hydroxycholesterol
Nicotinamide salvaging
Eicosanoids
Sterols are 12-hydroxylated by CYP8B1
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000532 kidney vascular congestion "obstruction of the normal flux of blood within the blood vessel network of the organ of secretion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: ae/ae
Genetic Background: (P x S)F1

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: ae/ae
Genetic Background: (P x S)F1

 MP:0002703 abnormal renal tubules "anomalous structure or development of the loops of Henle and collecting ducts in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: ae/ae
Genetic Background: (P x S)F1

 MP:0002842 increased blood pressure "increased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: ae/ae
Genetic Background: (P x S)F1

 MP:0003670 dilated glomerular capsule "an expansion in volume of the expanded beginning of a nephron that contains the glomerulus" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:91499]
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Allelic Composition: ae/ae
Genetic Background: (P x S)F1

 MP:0003675 kidney cysts "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: ae/ae
Genetic Background: (P x S)F1

 MP:0003946 renal necrosis "pathological cell death in the kidney, usually due to irreversible damage" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: ae/ae
Genetic Background: (P x S)F1

 MP:0003985 renal fibrosis "formation of fibrous tissue in the kidney as a result of repair or a reactive process" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: ae/ae
Genetic Background: (P x S)F1

 MP:0004970 kidney atrophy "wasting of the kidney due to injury or disease, resulting in reduced size" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: ae/ae
Genetic Background: (P x S)F1

 MP:0005553 increased circulating creatinine level "greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: ae/ae
Genetic Background: (P x S)F1

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: ae/ae
Genetic Background: (P x S)F1

 MP:0009814 increased prostaglandin level "increase in the amount in the body of any of a class of mediators with effects of vasodilation, vasoconstriction, and smooth muscle stimulation" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: ae/ae
Genetic Background: (P x S)F1

 MP:0009815 decreased prostaglandin level "reduction in the amount in the body of any of a class of mediators with effects of vasodilation, vasoconstriction, and smooth muscle stimulation" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: ae/ae
Genetic Background: (P x S)F1

 MP:0009818 abnormal thromboxane level 
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Allelic Composition: ae/ae
Genetic Background: (P x S)F1

 MP:0009866 abnormal aorta wall morphology "any structural anomaly of the part of the aorta that encloses the luminal space" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: ae/ae
Genetic Background: (P x S)F1

 MP:0009871 abnormal aorta tunica adventitia morphology "any structural anomaly of the outermost layer of the aorta wall, containing connective tissue and collagen and elastic fibers" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: ae/ae
Genetic Background: (P x S)F1

 MP:0009873 abnormal aorta tunica media morphology "any structural anomaly of the middle layer of the aorta wall, containing the smooth muscle layer and elastic fibers" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: ae/ae
Genetic Background: (P x S)F1

 MP:0010468 abnormal thoracic aorta morphology "any structural anomaly of the part of the aorta that extends from the origin at the heart to the diaphragm, and from which arises numerous branches that supply oxygenated blood to the chest cage and the organs within the chest" [http://www.medterms.com "MedicineNet.com"]
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Allelic Composition: ae/ae
Genetic Background: (P x S)F1

 MP:0011423 kidney cortex atrophy "acquired diminution of the size of the outer portion of the kidney located between the renal capsule and the renal medulla, associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]
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Allelic Composition: ae/ae
Genetic Background: (P x S)F1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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