ENSG00000124212


Homo sapiens

Features
Gene ID: ENSG00000124212
  
Biological name :PTGIS
  
Synonyms : prostaglandin I2 synthase / PTGIS / Q16647
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: -1
Band: q13.13
Gene start: 49503874
Gene end: 49568146
  
Corresponding Affymetrix probe sets: 208131_s_at (Human Genome U133 Plus 2.0 Array)   210702_s_at (Human Genome U133 Plus 2.0 Array)   211892_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000244043
NCBI entrez gene - 5740     See in Manteia.
OMIM - 601699
RefSeq - NM_000961
RefSeq Peptide - NP_000952
swissprot - Q16647
Ensembl - ENSG00000124212
  
Related genetic diseases (OMIM): 145500 - Hypertension, essential, 145500
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptgisENSDARG00000060094Danio rerio
 PtgisENSMUSG00000017969Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CYP8B1 / Q9UNU6 / cytochrome P450 family 8 subfamily B member 1ENSG0000018043241
CYP7B1 / O75881 / cytochrome P450 family 7 subfamily B member 1ENSG0000017281732
CYP7A1 / P22680 / cytochrome P450 family 7 subfamily A member 1ENSG0000016791032
Q9NYL5 / CYP39A1 / cytochrome P450 family 39 subfamily A member 1ENSG0000014623320


Protein motifs (from Interpro)
Interpro ID Name
 IPR001128  Cytochrome P450
 IPR002403  Cytochrome P450, E-class, group IV
 IPR024204  Cytochrome P450, cholesterol 7-alpha-monooxygenase-type
 IPR027286  Prostacyclin synthase
 IPR036396  Cytochrome P450 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001516 prostaglandin biosynthetic process IDA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006633 fatty acid biosynthetic process IEA
 biological_processGO:0006690 icosanoid metabolic process TAS
 biological_processGO:0006693 prostaglandin metabolic process IEA
 biological_processGO:0007566 embryo implantation IEA
 biological_processGO:0019371 cyclooxygenase pathway TAS
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IDA
 biological_processGO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway TAS
 biological_processGO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway IDA
 biological_processGO:0045019 negative regulation of nitric oxide biosynthetic process IDA
 biological_processGO:0045766 positive regulation of angiogenesis IMP
 biological_processGO:0046697 decidualization IEA
 biological_processGO:0050728 negative regulation of inflammatory response IDA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0071347 cellular response to interleukin-1 IEP
 biological_processGO:0071354 cellular response to interleukin-6 IEP
 biological_processGO:0071456 cellular response to hypoxia IDA
 biological_processGO:0097190 apoptotic signaling pathway IDA
 biological_processGO:1900119 positive regulation of execution phase of apoptosis IDA
 cellular_componentGO:0005615 extracellular space ISS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0005901 caveola IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008116 prostaglandin-I synthase activity TAS
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0016853 isomerase activity IEA
 molecular_functionGO:0020037 heme binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
Synthesis of bile acids and bile salts via 24-hydroxycholesterol
Synthesis of bile acids and bile salts via 27-hydroxycholesterol
Nicotinamide salvaging
Eicosanoids
Sterols are 12-hydroxylated by CYP8B1
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0001426 Multifactorial 
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 HP:0004421 Elevated systolic blood pressure 
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 HP:0004972 Elevated mean arterial pressure 
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 HP:0005117 Elevated diastolic blood pressure 
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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