ENSG00000167910


Homo sapiens

Features
Gene ID: ENSG00000167910
  
Biological name :CYP7A1
  
Synonyms : CYP7A1 / cytochrome P450 family 7 subfamily A member 1 / P22680
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: -1
Band: q12.1
Gene start: 58490178
Gene end: 58500236
  
Corresponding Affymetrix probe sets: 207406_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000301645
NCBI entrez gene - 1581     See in Manteia.
OMIM - 118455
RefSeq - NM_000780
RefSeq Peptide - NP_000771
swissprot - P22680
Ensembl - ENSG00000167910
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cyp7a1ENSDARG00000069018Danio rerio
 CYP7A1ENSGALG00000041222Gallus gallus
 Cyp7a1ENSMUSG00000028240Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CYP7B1 / O75881 / cytochrome P450 family 7 subfamily B member 1ENSG0000017281738
CYP8B1 / Q9UNU6 / cytochrome P450 family 8 subfamily B member 1ENSG0000018043233
PTGIS / Q16647 / prostaglandin I2 synthaseENSG0000012421232
Q9NYL5 / CYP39A1 / cytochrome P450 family 39 subfamily A member 1ENSG0000014623321


Protein motifs (from Interpro)
Interpro ID Name
 IPR001128  Cytochrome P450
 IPR002403  Cytochrome P450, E-class, group IV
 IPR017972  Cytochrome P450, conserved site
 IPR024204  Cytochrome P450, cholesterol 7-alpha-monooxygenase-type
 IPR030681  Cholesterol 7-alpha-monooxygenase
 IPR036396  Cytochrome P450 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006699 bile acid biosynthetic process ISS
 biological_processGO:0006707 cholesterol catabolic process ISS
 biological_processGO:0008202 steroid metabolic process IEA
 biological_processGO:0008203 cholesterol metabolic process IEA
 biological_processGO:0016125 sterol metabolic process TAS
 biological_processGO:0019216 regulation of lipid metabolic process TAS
 biological_processGO:0042632 cholesterol homeostasis ISS
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0070857 regulation of bile acid biosynthetic process IEA
 biological_processGO:0071333 cellular response to glucose stimulus IDA
 biological_processGO:0071397 cellular response to cholesterol IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031090 organelle membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISS
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0008123 cholesterol 7-alpha-monooxygenase activity TAS
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Synthesis of bile acids and bile salts
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
Synthesis of bile acids and bile salts via 27-hydroxycholesterol
PPARA activates gene expression
Endogenous sterols


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0001396 Cholestasis 
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 HP:0001403 Macrovesicular steatosis 
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 HP:0001513 Obesity "A status with BODY WEIGHT that is grossly above the acceptable or desirable weight, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY)." [MeSH:D009765]
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 HP:0001677 Coronary artery disease 
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 HP:0002155 Hypertriglyceridemia 
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 HP:0003124 Hypercholesterolemia 
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 HP:0003141 Increased beta-lipoproteins "An increase in the blood concentration of beta lipoprotein, which is a low-density lipoprotein involved in the blood transport of cholesterol." [HPO:curators]
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 HP:0004943 Accelerated atherosclerosis 
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 HP:0006573 Macro- and microvesicular steatosis, acute 
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 HP:0008372 Abnormality of vitamin A metabolism 
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 HP:0011980 Cholesterol gallstones "Gallstones composed primarily of cholesterol, usually about 2-3 cm in length with an oval form and a yellow or green/brown color." [HPO:probinson, pmid:12950109, pmid:16844493]
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 HP:0012115 Hepatitis "Inflammation of the liver." [HPO:probinson]
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 HP:0012397 Aortic atherosclerosis "The presence of atheromas or atherosclerotic plaques in the `aorta` (FMA:3734)." [HPO:probinson, pmid:16818829]
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 HP:0100514 Abnormality of vitamin E metabolism 
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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