ENSG00000146233


Homo sapiens

Features
Gene ID: ENSG00000146233
  
Biological name :CYP39A1
  
Synonyms : CYP39A1 / cytochrome P450 family 39 subfamily A member 1 / Q9NYL5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: p12.3
Gene start: 46549580
Gene end: 46652830
  
Corresponding Affymetrix probe sets: 1553977_a_at (Human Genome U133 Plus 2.0 Array)   220432_s_at (Human Genome U133 Plus 2.0 Array)   244407_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000477769
Ensembl peptide - ENSP00000275016
NCBI entrez gene - 51302     See in Manteia.
OMIM - 605994
RefSeq - XM_017010925
RefSeq - NM_001278738
RefSeq - NM_001278739
RefSeq - NM_016593
RefSeq - XM_011514658
RefSeq - XM_017010921
RefSeq - XM_017010922
RefSeq - XM_017010923
RefSeq - XM_017010924
RefSeq - XM_005249171
RefSeq Peptide - NP_001265667
RefSeq Peptide - NP_001265668
RefSeq Peptide - NP_057677
swissprot - Q9NYL5
swissprot - A0A087WTD2
Ensembl - ENSG00000146233
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cyp39a1ENSDARG00000017982Danio rerio
 CYP39A1ENSGALG00000016710Gallus gallus
 Q9JKJ9ENSMUSG00000023963Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CYP8B1 / Q9UNU6 / cytochrome P450 family 8 subfamily B member 1ENSG0000018043225
CYP7A1 / P22680 / cytochrome P450 family 7 subfamily A member 1ENSG0000016791023
CYP7B1 / O75881 / cytochrome P450 family 7 subfamily B member 1ENSG0000017281723
PTGIS / Q16647 / prostaglandin I2 synthaseENSG0000012421222


Protein motifs (from Interpro)
Interpro ID Name
 IPR001128  Cytochrome P450
 IPR002403  Cytochrome P450, E-class, group IV
 IPR024204  Cytochrome P450, cholesterol 7-alpha-monooxygenase-type
 IPR036396  Cytochrome P450 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006699 bile acid biosynthetic process IEA
 biological_processGO:0006707 cholesterol catabolic process IEA
 biological_processGO:0007586 digestion TAS
 biological_processGO:0008202 steroid metabolic process IEA
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0016125 sterol metabolic process TAS
 biological_processGO:0030573 bile acid catabolic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031090 organelle membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle TAS
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0008387 steroid 7-alpha-hydroxylase activity IEA
 molecular_functionGO:0008396 oxysterol 7-alpha-hydroxylase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Synthesis of bile acids and bile salts via 24-hydroxycholesterol
Endogenous sterols


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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