ENSG00000180432


Homo sapiens

Features
Gene ID: ENSG00000180432
  
Biological name :CYP8B1
  
Synonyms : CYP8B1 / cytochrome P450 family 8 subfamily B member 1 / Q9UNU6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: p22.1
Gene start: 42856005
Gene end: 42876165
  
Corresponding Affymetrix probe sets: 232494_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000318867
Ensembl peptide - ENSP00000404499
NCBI entrez gene - 1582     See in Manteia.
OMIM - 602172
RefSeq - NM_004391
RefSeq Peptide - NP_004382
swissprot - C9JFR9
swissprot - Q9UNU6
Ensembl - ENSG00000180432
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cyp8b1ENSDARG00000053068Danio rerio
 cyp8b2ENSDARG00000097556Danio rerio
 cyp8b3ENSDARG00000097559Danio rerio
 CYP8B1ENSGALG00000033511Gallus gallus
 Cyp8b1ENSMUSG00000050445Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PTGIS / Q16647 / prostaglandin I2 synthaseENSG0000012421241
CYP7A1 / P22680 / cytochrome P450 family 7 subfamily A member 1ENSG0000016791033
CYP7B1 / O75881 / cytochrome P450 family 7 subfamily B member 1ENSG0000017281733
Q9NYL5 / CYP39A1 / cytochrome P450 family 39 subfamily A member 1ENSG0000014623323


Protein motifs (from Interpro)
Interpro ID Name
 IPR001128  Cytochrome P450
 IPR002403  Cytochrome P450, E-class, group IV
 IPR024204  Cytochrome P450, cholesterol 7-alpha-monooxygenase-type
 IPR030686  Cytochrome P450 8B1
 IPR036396  Cytochrome P450 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006699 bile acid biosynthetic process TAS
 biological_processGO:0016125 sterol metabolic process TAS
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031090 organelle membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0008397 sterol 12-alpha-hydroxylase activity TAS
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0019825 oxygen binding TAS
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0033778 7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity TAS
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
Synthesis of bile acids and bile salts via 24-hydroxycholesterol
Synthesis of bile acids and bile salts via 27-hydroxycholesterol
Nicotinamide salvaging
Eicosanoids
Sterols are 12-hydroxylated by CYP8B1
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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