ENSMUSG00000023963


Mus musculus

Features
Gene ID: ENSMUSG00000023963
  
Biological name :Cyp39a1
  
Synonyms : 24-hydroxycholesterol 7-alpha-hydroxylase / Cyp39a1 / Q9JKJ9
  
Possible biological names infered from orthology : cytochrome P450 family 39 subfamily A member 1 / Q9NYL5
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: B3
Gene start: 43667425
Gene end: 43751431
  
Corresponding Affymetrix probe sets: 10445308 (MoGene1.0st)   1418780_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000130073
NCBI entrez gene - 56050     See in Manteia.
MGI - MGI:1927096
RefSeq - NM_018887
RefSeq - NM_001285947
RefSeq - NM_001285948
RefSeq Peptide - NP_001272876
RefSeq Peptide - NP_001272877
RefSeq Peptide - NP_061375
swissprot - Q544S6
swissprot - Q9JKJ9
Ensembl - ENSMUSG00000023963
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cyp39a1ENSDARG00000017982Danio rerio
 CYP39A1ENSGALG00000016710Gallus gallus
 Q9NYL5ENSG00000146233Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cyp8b1 / cytochrome P450 family 8 subfamily B member 1 / Q9UNU6*ENSMUSG0000005044524
Cyp7b1 / Q60991 / 25-hydroxycholesterol 7-alpha-hydroxylase / O75881* / cytochrome P450 family 7 subfamily B member 1*ENSMUSG0000003951923
Cyp7a1 / Q64505 / Cholesterol 7-alpha-monooxygenase / P22680* / cytochrome P450 family 7 subfamily A member 1*ENSMUSG0000002824023
Ptgis / O35074 / prostaglandin I2 (prostacyclin) synthase / Q16647* / prostaglandin I2 synthase*ENSMUSG0000001796921


Protein motifs (from Interpro)
Interpro ID Name
 IPR001128  Cytochrome P450
 IPR002403  Cytochrome P450, E-class, group IV
 IPR024204  Cytochrome P450, cholesterol 7-alpha-monooxygenase-type
 IPR036396  Cytochrome P450 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006699 bile acid biosynthetic process IEA
 biological_processGO:0006707 cholesterol catabolic process IDA
 biological_processGO:0007586 digestion TAS
 biological_processGO:0008202 steroid metabolic process IEA
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0030573 bile acid catabolic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031090 organelle membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle TAS
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0008387 steroid 7-alpha-hydroxylase activity IDA
 molecular_functionGO:0008396 oxysterol 7-alpha-hydroxylase activity ISO
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Synthesis of bile acids and bile salts via 24-hydroxycholesterol
Endogenous sterols


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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