ENSMUSG00000039519


Mus musculus

Features
Gene ID: ENSMUSG00000039519
  
Biological name :Cyp7b1
  
Synonyms : 25-hydroxycholesterol 7-alpha-hydroxylase / Cyp7b1 / Q60991
  
Possible biological names infered from orthology : cytochrome P450 family 7 subfamily B member 1 / O75881
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: A1
Gene start: 18071950
Gene end: 18243338
  
Corresponding Affymetrix probe sets: 10497381 (MoGene1.0st)   1421074_at (Mouse Genome 430 2.0 Array)   1421075_s_at (Mouse Genome 430 2.0 Array)   1446995_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000037487
NCBI entrez gene - 13123     See in Manteia.
MGI - MGI:104978
RefSeq - XM_006535384
RefSeq - NM_007825
RefSeq - XM_006535383
RefSeq Peptide - NP_031851
swissprot - Q60991
Ensembl - ENSMUSG00000039519
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cyp7b1ENSDARG00000008858Danio rerio
 CYP7B1ENSGALG00000029435Gallus gallus
 CYP7B1ENSG00000172817Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cyp7a1 / Q64505 / Cholesterol 7-alpha-monooxygenase / P22680* / cytochrome P450 family 7 subfamily A member 1*ENSMUSG0000002824037
Cyp8b1 / cytochrome P450 family 8 subfamily B member 1 / Q9UNU6*ENSMUSG0000005044531
Ptgis / O35074 / prostaglandin I2 (prostacyclin) synthase / Q16647* / prostaglandin I2 synthase*ENSMUSG0000001796929
Q9JKJ9 / Cyp39a1 / 24-hydroxycholesterol 7-alpha-hydroxylase / Q9NYL5* / cytochrome P450 family 39 subfamily A member 1*ENSMUSG0000002396321


Protein motifs (from Interpro)
Interpro ID Name
 IPR001128  Cytochrome P450
 IPR002403  Cytochrome P450, E-class, group IV
 IPR024204  Cytochrome P450, cholesterol 7-alpha-monooxygenase-type
 IPR036396  Cytochrome P450 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006699 bile acid biosynthetic process IEA
 biological_processGO:0007586 digestion TAS
 biological_processGO:0008202 steroid metabolic process IEA
 biological_processGO:0008203 cholesterol metabolic process IEA
 biological_processGO:0033147 negative regulation of intracellular estrogen receptor signaling pathway IMP
 biological_processGO:0035754 B cell chemotaxis IMP
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0060740 prostate gland epithelium morphogenesis IMP
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031090 organelle membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle TAS
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0008396 oxysterol 7-alpha-hydroxylase activity IMP
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Synthesis of bile acids and bile salts
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
Synthesis of bile acids and bile salts via 27-hydroxycholesterol
Endogenous sterols


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000367 abnormal coat/ hair morphology "anomalous color, structure, growth, or texture of the hair" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cyp27b1tm1b(EUCOMM)Hmgu/Cyp27b1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Cyp27b1tm1b(EUCOMM)Hmgu/Tcp

 MP:0000628 abnormal mammary gland development "aberration in the differentiation of the mammary gland during early embryogenesis or during sexual maturity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Eno2-Ighmbp2)17Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

 MP:0001510 abnormal coat appearance "coat that looks different from the usual state " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cyp27b1tm1b(EUCOMM)Hmgu/Cyp27b1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Cyp27b1tm1b(EUCOMM)Hmgu/Tcp

 MP:0001807 decreased IgA "less than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: 129X1Bom.129S7-Gnai2tm1Lbi

 MP:0001927 abnormal oestrous cycle (sensu Rodentia) "failure of or aberrant timing of the sexual cycle of female animals" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Eno2-Ighmbp2)17Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

 MP:0003378 early sexual maturation "pubertal changes occur at an earlier than normal age" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Eno2-Ighmbp2)17Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

 MP:0003507 abnormal ovary physiology "anomaly or loss either the production of female germ cells or the endocrine cells for the production of estrogen and progesterone" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Eno2-Ighmbp2)17Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

 MP:0003572 abnormal uterus development "abnormal morphogenesis of the female muscular organ of gestation" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Eno2-Ighmbp2)17Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

 MP:0004894 uterus atrophy "wasting of the uterus due to injury or disease resulting in reduced size" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Eno2-Ighmbp2)17Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

 MP:0005278 abnormal cholesterol homeostasis "anomaly in the state of equilibrium in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:71350]
Show

Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: 129X1Bom.129S7-Gnai2tm1Lbi

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cyp27b1tm1b(EUCOMM)Hmgu/Cyp27b1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Cyp27b1tm1b(EUCOMM)Hmgu/Tcp

 MP:0009009 absent estrous cycle "failure of female animals to enter or progress through their sexual cycle" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Eno2-Ighmbp2)17Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cyp27b1tm1b(EUCOMM)Hmgu/Cyp27b1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Cyp27b1tm1b(EUCOMM)Hmgu/Tcp

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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