ENSDARG00000078261


Danio rerio

Features
Gene ID: ENSDARG00000078261
  
Biological name :nphp3
  
Synonyms : nephronophthisis 3 / nphp3 / P0CI65
  
Possible biological names infered from orthology : Gm28305 / nephrocystin 3 / NPHP3-ACAD11 / NPHP3-ACAD11 readthrough (NMD candidate) / Q7TNH6 / Q7Z494
  
Species: Danio rerio
  
Chr. number: 24
Strand: 1
Band:
Gene start: 9612218
Gene end: 9683374
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000101271
Ensembl peptide - ENSDARP00000143907
Ensembl peptide - ENSDARP00000119076
NCBI entrez gene - 562601     See in Manteia.
RefSeq - NM_001202441
RefSeq - XM_009297293
RefSeq Peptide - NP_001189370
swissprot - E9QBN2
swissprot - P0CI65
swissprot - A0A286Y9S2
ZFIN ID - ZDB-GENE-091204-117
Ensembl - ENSDARG00000078261
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000034586Gallus gallus
 NPHP3ENSG00000113971Homo sapiens
 NPHP3-ACAD11ENSG00000274810Homo sapiens
 Gm28305ENSMUSG00000101152Mus musculus
 Nphp3ENSMUSG00000032558Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
klc1a / kinesin light chain 1a / KLC1* / Q07866* / AL139300.1* / kinesin light chain 1* / kinesin light chain 1 isoform 1G *ENSDARG0000000979612
klc3 / kinesin light chain 3 / Q6P597* / Q91W40*ENSDARG0000005596510
klc4 / kinesin light chain 4 / Q9DBS5* / Q9NSK0* / Mus musculus kinesin light chain 4 (Klc4), transcript variant 2, mRNA.*ENSDARG000000869852


Protein motifs (from Interpro)
Interpro ID Name
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR011991  ArsR-like helix-turn-helix domain
 IPR013026  Tetratricopeptide repeat-containing domain
 IPR019734  Tetratricopeptide repeat
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003146 heart jogging IMP
 biological_processGO:0007601 visual perception IMP
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0048793 pronephros development IGI
 biological_processGO:0060026 convergent extension IMP
 biological_processGO:0060271 cilium assembly IMP
 biological_processGO:0060972 left/right pattern formation IMP
 biological_processGO:0070121 Kupffer"s vesicle development IMP
 cellular_componentGO:0005929 cilium ISS
 cellular_componentGO:0042995 cell projection IEA


Pathways (from Reactome)
Pathway description
Trafficking of myristoylated proteins to the cilium


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000001 Kupffer s vesicle Kupffers vesicle cilium decreased length , abnormal
Kupffers vesicle cilium decreased amount , abnormal
Kupffers vesicle morphology , abnormal
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 ZFA:0000009 cardiac ventricle cardiac ventricle mislocalised , abnormal
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 ZFA:0000110 fourth ventricle fourth ventricle hydrocephalic , abnormal
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 ZFA:0000114 heart heart centered , abnormal
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 ZFA:0000123 liver liver mislocalised , abnormal
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 ZFA:0000140 pancreas pancreas mislocalised , abnormal
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 ZFA:0000151 pronephros pronephros cystic , abnormal
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 ZFA:0000471 atrium atrium mislocalised , abnormal
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 ZFA:0001094 whole organism whole organism curved ventral , abnormal
whole organism decreased length , abnormal
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 ZFA:0001115 trunk trunk curved ventral , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000009629 Q90Z08 / unc119.1 / unc-119 homolog 1 / A6NIH7* / Q8C4B4* / UNC119B* / unc-119 lipid binding chaperone B*  / complex / reaction
 ENSDARG00000056794 zgc:110197 / ARL3 (1 of many) / ARL3* / P36405* / Q9WUL7* / ADP ribosylation factor like GTPase 3* / ADP-ribosylation factor-like protein 3 *  / complex / reaction
 ENSDARG00000071409 arl3 / Q1MTE5 / ADP-ribosylation factor-like 3 / P36405* / Q9WUL7* / ADP ribosylation factor like GTPase 3* / ADP-ribosylation factor-like protein 3 *  / reaction / complex






 

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