ENSDARG00000101295


Danio rerio

Features
Gene ID: ENSDARG00000101295
  
Biological name :psmd4a
  
Synonyms : proteasome 26S subunit, non-ATPase 4a / psmd4a
  
Possible biological names infered from orthology : 26S proteasome non-ATPase regulatory subunit 4 / O35226 / P55036 / proteasome 26S subunit, non-ATPase 4 / PSMD4
  
Species: Danio rerio
  
Chr. number: 19
Strand: -1
Band:
Gene start: 10871601
Gene end: 10881508
  
Corresponding Affymetrix probe sets: Dr.22697.1.A1_at (Zebrafish Array)   NM_001002112_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000138300
Ensembl peptide - ENSDARP00000133816
NCBI entrez gene - 415202     See in Manteia.
RefSeq - NM_001002112
RefSeq Peptide - NP_001002112
swissprot - A0A0R4IJB5
swissprot - Q6IQC6
ZFIN ID - ZDB-GENE-040625-104
Ensembl - ENSDARG00000101295
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PSMD4ENSGALG00000028505Gallus gallus
 PSMD4ENSG00000159352Homo sapiens
 Psmd4ENSMUSG00000005625Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
psmd4b / proteasome 26S subunit, non-ATPase 4b / PSMD4* / O35226* / P55036* / proteasome 26S subunit, non-ATPase 4* / 26S proteasome non-ATPase regulatory subunit 4 *ENSDARG0000002327985
PSMD4 (1 of many) / proteasome 26S subunit, non-ATPase 4 / PSMD4* / P55036* / O35226* / 26S proteasome non-ATPase regulatory subunit 4 *ENSDARG0000010495227


Protein motifs (from Interpro)
Interpro ID Name
 IPR002035  von Willebrand factor, type A
 IPR003903  Ubiquitin interacting motif
 IPR027040  Proteasome subunit Rpn10


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA
 biological_processGO:0043248 proteasome assembly IBA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005829 cytosol IBA
 cellular_componentGO:0008540 proteasome regulatory particle, base subcomplex IEA
 molecular_functionGO:0031593 polyubiquitin modification-dependent protein binding IBA


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Hedgehog on state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
Ubiquitin-dependent degradation of Cyclin D1
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Interleukin-1 signaling
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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