ENSMUSG00000005625


Mus musculus

Features
Gene ID: ENSMUSG00000005625
  
Biological name :Psmd4
  
Synonyms : 26S proteasome non-ATPase regulatory subunit 4 / O35226 / Psmd4
  
Possible biological names infered from orthology : P55036 / proteasome 26S subunit, non-ATPase 4
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: F2.1
Gene start: 95032694
Gene end: 95042614
  
Corresponding Affymetrix probe sets: 10500054 (MoGene1.0st)   1418874_a_at (Mouse Genome 430 2.0 Array)   1425859_a_at (Mouse Genome 430 2.0 Array)   1451725_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000071589
Ensembl peptide - ENSMUSP00000102857
Ensembl peptide - ENSMUSP00000113554
Ensembl peptide - ENSMUSP00000114545
NCBI entrez gene - 19185     See in Manteia.
MGI - MGI:1201670
RefSeq - XM_006501137
RefSeq - NM_001282017
RefSeq - NM_008951
RefSeq Peptide - NP_001268946
RefSeq Peptide - NP_032977
swissprot - O35226
swissprot - Q3ULG4
swissprot - F7AI87
Ensembl - ENSMUSG00000005625
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PSMD4 (1 of many)ENSDARG00000104952Danio rerio
 psmd4aENSDARG00000101295Danio rerio
 psmd4bENSDARG00000023279Danio rerio
 PSMD4ENSGALG00000028505Gallus gallus
 PSMD4ENSG00000159352Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002035  von Willebrand factor, type A
 IPR003903  Ubiquitin interacting motif
 IPR027040  Proteasome subunit Rpn10
 IPR036465  von Willebrand factor A-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA
 biological_processGO:0043248 proteasome assembly IBA
 cellular_componentGO:0000502 proteasome complex ISO
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IBA
 cellular_componentGO:0008540 proteasome regulatory particle, base subcomplex IBA
 cellular_componentGO:0022624 proteasome accessory complex IDA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0031593 polyubiquitin modification-dependent protein binding IBA
 molecular_functionGO:0042802 identical protein binding ISO


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog on state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
Ubiquitin-dependent degradation of Cyclin D1
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Interleukin-1 signaling
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gad1tm1.1Rpa/Gad1+
Genetic Background: Not Specified

 MP:0001695 abnormal gastrulation "anomalous development and invagination of the embryonic germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Psmd4tm2Smta/Psmd4tm2Smta,Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic Background: involves: C57BL/6 * CBA * DBA

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Psmd4tm2Smta/Psmd4tm2Smta,Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic Background: involves: C57BL/6 * CBA * DBA

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Psmd4tm2Smta/Psmd4tm2Smta,Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic Background: involves: C57BL/6 * CBA * DBA

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gad1tm1.1Rpa/Gad1+
Genetic Background: Not Specified

 MP:0004180 failure of initiation of embryo turning "failure to begin the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gad1tm1.1Rpa/Gad1+
Genetic Background: Not Specified

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Gad1tm1.1Rpa/Gad1+
Genetic Background: Not Specified

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Psmd4tm2Smta/Psmd4tm2Smta,Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic Background: involves: C57BL/6 * CBA * DBA

 MP:0012114 absent inner cell mass proliferation 
Show

Allelic Composition: Psmd4tm2Smta/Psmd4tm2Smta,Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic Background: involves: C57BL/6 * CBA * DBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr