ENSGALG00000028505


Gallus gallus

Features
Gene ID: ENSGALG00000028505
  
Biological name :PSMD4
  
Synonyms : proteasome 26S subunit, non-ATPase 4 / PSMD4
  
Possible biological names infered from orthology : 26S proteasome non-ATPase regulatory subunit 4 / O35226 / P55036
  
Species: Gallus gallus
  
Chr. number: 25
Strand: 1
Band:
Gene start: 2694151
Gene end: 2698197
  
Corresponding Affymetrix probe sets: Gga.6030.1.S1_s_at (Chicken Array)   GgaAffx.13073.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000043088
NCBI entrez gene - 100216364     See in Manteia.
RefSeq - NM_001142390
RefSeq Peptide - NP_001135862
swissprot - R4GLK3
Ensembl - ENSGALG00000028505
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PSMD4 (1 of many)ENSDARG00000104952Danio rerio
 psmd4aENSDARG00000101295Danio rerio
 psmd4bENSDARG00000023279Danio rerio
 PSMD4ENSG00000159352Homo sapiens
 Psmd4ENSMUSG00000005625Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002035  von Willebrand factor, type A
 IPR003903  Ubiquitin interacting motif
 IPR027040  Proteasome subunit Rpn10


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA
 biological_processGO:0043248 proteasome assembly IBA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0008540 proteasome regulatory particle, base subcomplex IEA
 cellular_componentGO:0022624 proteasome accessory complex IEA
 molecular_functionGO:0031593 polyubiquitin modification-dependent protein binding IBA


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog on state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
Ubiquitin-dependent degradation of Cyclin D1
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Interleukin-1 signaling
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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