ENSDARG00000103953


Danio rerio

Features
Gene ID: ENSDARG00000103953
  
Biological name :med12
  
Synonyms : med12 / mediator complex subunit 12
  
Possible biological names infered from orthology : A2AGH6 / Mediator of RNA polymerase II transcription subunit 12 / Q93074
  
Species: Danio rerio
  
Chr. number: 14
Strand: 1
Band:
Gene start: 23593989
Gene end: 23679139
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000130194
Ensembl peptide - ENSDARP00000133775
NCBI entrez gene - 566632     See in Manteia.
RefSeq - NM_001039461
RefSeq - XM_009291037
RefSeq - XM_009291038
RefSeq Peptide - NP_001034550
swissprot - A0A0R4IEY1
swissprot - A0A0R4IBL3
ZFIN ID - ZDB-GENE-060125-1
Ensembl - ENSDARG00000103953
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MED12ENSGALG00000036322Gallus gallus
 MED12ENSG00000184634Homo sapiens
 Med12ENSMUSG00000079487Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR019035  Mediator complex, subunit Med12
 IPR021989  Mediator complex, subunit Med12, catenin-binding
 IPR021990  Mediator complex, subunit Med12, LCEWAV-domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 cellular_componentGO:0016592 mediator complex IEA
 molecular_functionGO:0008013 beta-catenin binding IEA


Pathways (from Reactome)
Pathway description
Generic Transcription Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain quality , abnormal
brain apoptotic , abnormal
brain morphology , abnormal
brain neuron apoptotic , abnormal
Show

 ZFA:0000013 cranial ganglion cranial ganglion has fewer parts of type sensory neuron , abnormal
Show

 ZFA:0000029 hindbrain hindbrain decreased size , abnormal
hindbrain malformed , abnormal
hindbrain lacks all parts of type fourth ventricle , abnormal
hindbrain has fewer parts of type serotonergic neuron , abnormal
Show

 ZFA:0000032 hypothalamus hypothalamus dopaminergic neuron decreased amount , abnormal
hypothalamus lacks parts or has fewer parts of type dopaminergic neuron , abnormal
Show

 ZFA:0000042 midbrain hindbrain boundary midbrain hindbrain boundary quality , abnormal
midbrain hindbrain boundary morphology , abnormal
Show

 ZFA:0000075 spinal cord spinal cord molecular quality , abnormal
Show

 ZFA:0000079 telencephalon telencephalon lacks parts or has fewer parts of type dopaminergic neuron , abnormal
Show

 ZFA:0000094 blood island blood island aplastic , abnormal
Show

 ZFA:0000095 pharyngeal arch 3-7 skeleton pharyngeal arch 3-7 skeleton quality , abnormal
Show

 ZFA:0000101 diencephalon diencephalon lacks parts or has fewer parts of type dopaminergic neuron , abnormal
Show

 ZFA:0000106 extension extension decreased thickness , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
eye quality , abnormal
Show

 ZFA:0000109 forebrain forebrain quality , abnormal
forebrain decreased size , abnormal
forebrain has fewer parts of type dopaminergic neuron , abnormal
Show

 ZFA:0000110 fourth ventricle fourth ventricle decreased size , abnormal
Show

 ZFA:0000114 heart heart morphology , abnormal
Show

 ZFA:0000123 liver liver morphology , abnormal
liver decreased size , abnormal
Show

 ZFA:0000128 midbrain midbrain decreased size , abnormal
midbrain malformed , abnormal
midbrain deformed , abnormal
Show

 ZFA:0000140 pancreas pancreas morphology , abnormal
pancreas decreased size , abnormal
Show

 ZFA:0000141 pectoral fin bud pectoral fin bud embryonic pectoral fin morphogenesis decreased process quality , abnormal
Show

 ZFA:0000151 pronephros pronephros quality , abnormal
Show

 ZFA:0000159 tectal ventricle tectal ventricle decreased size , abnormal
Show

 ZFA:0000175 posterior lateral line nerve posterior lateral line nerve axon decreased length , abnormal
Show

 ZFA:0000217 inner ear inner ear morphology , abnormal
inner ear decreased size , abnormal
Show

 ZFA:0000257 pectoral fin cartilage pectoral fin cartilage malformed , abnormal
Show

 ZFA:0000282 sensory system sensory system quality , abnormal
Show

 ZFA:0000339 digestive system digestive system morphology , abnormal
Show

 ZFA:0000396 nervous system nervous system quality , abnormal
Show

 ZFA:0000539 locus coeruleus locus coeruleus has fewer parts of type norepinephrine secreting cell , abnormal
locus coeruleus lacks parts or has fewer parts of type neuron , abnormal
Show

 ZFA:0000944 posterior lateral line posterior lateral line molecular quality , abnormal
Show

 ZFA:0001094 whole organism whole organism dead , abnormal
whole organism lethal (sensu genetics) , abnormal
whole organism viability , abnormal
Show

 ZFA:0001100 hepatic duct hepatic duct morphology , abnormal
Show

 ZFA:0001161 pectoral fin pectoral fin decreased length , abnormal
Show

 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton morphology , abnormal
Show

 ZFA:0001249 exocrine pancreas exocrine pancreas morphology , abnormal
exocrine pancreas increased amount , abnormal
Show

 ZFA:0001259 forebrain ventricle forebrain ventricle decreased size , abnormal
Show

 ZFA:0001261 ventricular system ventricular system structure , abnormal
ventricular system morphology , abnormal
ventricular system collapsed , abnormal
Show

 ZFA:0001359 pineal complex pineal complex has fewer parts of type photoreceptor cell , abnormal
Show

 ZFA:0001360 parapineal organ parapineal organ aplastic , abnormal
Show

 ZFA:0001369 anterior pancreatic bud anterior pancreatic bud increased amount , abnormal
Show

 ZFA:0001372 pancreatic duct pancreatic duct morphology , abnormal
Show

 ZFA:0001576 sympathetic nervous system sympathetic nervous system has fewer parts of type norepinephrine secreting cell , abnormal
sympathetic nervous system lacks parts or has fewer parts of type sympathetic neuron , abnormal
Show

 ZFA:0001692 hindbrain commissure hindbrain commissure neuron decreased amount , abnormal
Show

 ZFA:0009046 T cell T cell absent , abnormal
Show

 ZFA:0009090 pigment cell pigment cell irregular spatial pattern , abnormal
Show

 ZFA:0009111 hepatocyte hepatocyte morphology , abnormal
Show

 ZFA:0009301 dopaminergic neuron dopaminergic neuron axon absent , abnormal
dopaminergic neuron neuron development disrupted , abnormal
dopaminergic neuron axon development disrupted , abnormal
Show

 ZFA:0009323 thrombocyte thrombocyte absent , abnormal
Show

 ZFA:0009326 myeloid leukocyte myeloid leukocyte decreased amount , abnormal
Show

 ZFA:0009327 neutrophil neutrophil decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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