ENSMUSG00000079487


Mus musculus

Features
Gene ID: ENSMUSG00000079487
  
Biological name :Med12
  
Synonyms : A2AGH6 / Med12 / Mediator of RNA polymerase II transcription subunit 12
  
Possible biological names infered from orthology : mediator complex subunit 12 / Q93074
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: D
Gene start: 101274030
Gene end: 101297465
  
Corresponding Affymetrix probe sets: 10601099 (MoGene1.0st)   10601150 (MoGene1.0st)   1425585_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000085260
Ensembl peptide - ENSMUSP00000112852
Ensembl peptide - ENSMUSP00000112729
Ensembl peptide - ENSMUSP00000085269
NCBI entrez gene - 59024     See in Manteia.
MGI - MGI:1926212
RefSeq - NM_021521
RefSeq Peptide - NP_067496
swissprot - A2AGH9
swissprot - A2AGH8
swissprot - A2AGH6
Ensembl - ENSMUSG00000079487
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 med12ENSDARG00000103953Danio rerio
 MED12ENSGALG00000036322Gallus gallus
 MED12ENSG00000184634Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Med12l / Q8BQM9 / Mediator of RNA polymerase II transcription subunit 12-like protein / Q86YW9* / mediator complex subunit 12 like*ENSMUSG0000005647658


Protein motifs (from Interpro)
Interpro ID Name
 IPR019035  Mediator complex, subunit Med12
 IPR021989  Mediator complex, subunit Med12, catenin-binding
 IPR021990  Mediator complex, subunit Med12, LCEWAV-domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001756 somitogenesis IMP
 biological_processGO:0001843 neural tube closure IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006367 transcription initiation from RNA polymerase II promoter ISO
 biological_processGO:0007492 endoderm development IMP
 biological_processGO:0007507 heart development IMP
 biological_processGO:0014003 oligodendrocyte development IMP
 biological_processGO:0014044 Schwann cell development IMP
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0019827 stem cell population maintenance IMP
 biological_processGO:0021510 spinal cord development IMP
 biological_processGO:0021915 neural tube development IMP
 biological_processGO:0030178 negative regulation of Wnt signaling pathway ISO
 biological_processGO:0030518 intracellular steroid hormone receptor signaling pathway ISO
 biological_processGO:0030521 androgen receptor signaling pathway ISO
 biological_processGO:0036342 post-anal tail morphogenesis IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0048568 embryonic organ development IMP
 biological_processGO:0048702 embryonic neurocranium morphogenesis IMP
 biological_processGO:0060070 canonical Wnt signaling pathway IMP
 biological_processGO:0060071 Wnt signaling pathway, planar cell polarity pathway IMP
 biological_processGO:0090245 axis elongation involved in somitogenesis IMP
 biological_processGO:1990403 embryonic brain development IMP
 cellular_componentGO:0000151 ubiquitin ligase complex IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0016592 mediator complex ISO
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding IGI
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003712 transcription coregulator activity ISO
 molecular_functionGO:0003713 transcription coactivator activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008013 beta-catenin binding IEA
 molecular_functionGO:0008022 protein C-terminus binding ISO
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0019904 protein domain specific binding ISO
 molecular_functionGO:0046966 thyroid hormone receptor binding ISO
 molecular_functionGO:0061630 ubiquitin protein ligase activity IEA


Pathways (from Reactome)
Pathway description
Generic Transcription Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000074 abnormal neurocranium morphology "malformed bones of the skull enclosing the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]
Show

Allelic Composition: Med12tm1.1Hsch/Med12+,Tg(CMV-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
Show

Allelic Composition: Erbb2tm8(Erbb2)Mul/Erbb2+,Ptentm1Hwu/Ptentm1Hwu,Tg(MMTV-cre)7Mul/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Med12tm1.1Hsch/Med12+,Tg(CMV-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
Show

Allelic Composition: Erbb2tm8(Erbb2)Mul/Erbb2+,Ptentm1Hwu/Ptentm1Hwu,Tg(MMTV-cre)7Mul/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N

 MP:0001688 abnormal somite development "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Erbb2tm8(Erbb2)Mul/Erbb2+,Ptentm1Hwu/Ptentm1Hwu,Tg(MMTV-cre)7Mul/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N

 MP:0001691 abnormal somite shape "atypical characteristic surface configuration of a segmental mass along the notochord of the developing embryo" [J:37888]
Show

Allelic Composition: Erbb2tm8(Erbb2)Mul/Erbb2+,Ptentm1Hwu/Ptentm1Hwu,Tg(MMTV-cre)7Mul/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Erbb2tm8(Erbb2)Mul/Erbb2+,Ptentm1Hwu/Ptentm1Hwu,Tg(MMTV-cre)7Mul/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N

Allelic Composition: Med12tm1.1Hsch/Med12+,Tg(CMV-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Erbb2tm8(Erbb2)Mul/Erbb2+,Ptentm1Hwu/Ptentm1Hwu,Tg(MMTV-cre)7Mul/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N

Allelic Composition: Med12tm1.1Hsch/Med12tm1.1Hsch
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

 MP:0002884 abnormal branchial arches "malformation or anomaly in the transient structures of the embryo that develop into regions of the head, neck and ears" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Erbb2tm8(Erbb2)Mul/Erbb2+,Ptentm1Hwu/Ptentm1Hwu,Tg(MMTV-cre)7Mul/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N

 MP:0002950 abnormal neural crest cell migration "defect in the dispersion of the transient and migratory group of cells that emerge from the dorsal region of the neural tube and migrate to many peripheral locations to form various tissues of the adult" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Erbb2tm8(Erbb2)Mul/Erbb2+,Ptentm1Hwu/Ptentm1Hwu,Tg(MMTV-cre)7Mul/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N

 MP:0003051 curly tail "a loop or corkscrew-like curl in the tail" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Med12tm1.1Hsch/Med12+,Tg(CMV-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0003400 kinked neural tube "twists or kinks in the embryonic neural tube" [J:66514, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Erbb2tm8(Erbb2)Mul/Erbb2+,Ptentm1Hwu/Ptentm1Hwu,Tg(MMTV-cre)7Mul/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N

 MP:0004073 caudal body truncation "caudal part of body truncated with anterior portion relatively normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Erbb2tm8(Erbb2)Mul/Erbb2+,Ptentm1Hwu/Ptentm1Hwu,Tg(MMTV-cre)7Mul/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N

 MP:0004251 failure of looping morphogenesis "failure of the primitive heart tube to initiate or complete looping" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Erbb2tm8(Erbb2)Mul/Erbb2+,Ptentm1Hwu/Ptentm1Hwu,Tg(MMTV-cre)7Mul/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N

 MP:0004601 abnormal vertebral spinous process "any structural anomaly of the dorsal projection of the vertebral arch that projects backward and downward from the junction of the laminae, and serves for the attachment of muscles and ligaments" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Med12tm1.1Hsch/Med12+,Tg(CMV-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004603 absent vertebral arch "loss of the dorsal part of a vertebra, consisting of a pair of pedicles, a pair of laminae, and seven processes (four articular processes, two transverse processes, and one spinous process)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Med12tm1.1Hsch/Med12+,Tg(CMV-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005223 abnormal anterior-posterior polarity of the somites "anomalous development or formation of the somites along the axis that runs from the front to the back surface of the body " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:72325]
Show

Allelic Composition: Erbb2tm8(Erbb2)Mul/Erbb2+,Ptentm1Hwu/Ptentm1Hwu,Tg(MMTV-cre)7Mul/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N

 MP:0006337 abnormal first branchial arch morphology "anomaly in the structure of the first arch which contributes to development of mastication muscles, maxilla, mandible, incus, malleus, Meckel s cartilage, trigeminal nerve, and maxillary artery" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Erbb2tm8(Erbb2)Mul/Erbb2+,Ptentm1Hwu/Ptentm1Hwu,Tg(MMTV-cre)7Mul/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N

 MP:0006345 absent second branchial arch "missing the second branchial arch" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Erbb2tm8(Erbb2)Mul/Erbb2+,Ptentm1Hwu/Ptentm1Hwu,Tg(MMTV-cre)7Mul/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N

 MP:0008784 craniorachischisis "congenital fissure of the skull and vertebral column" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Med12tm1.1Hsch/Med12+,Tg(CMV-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0010642 absent third branchial arch "absence of the structure of the third are which contributes to the development of the hyoid bone, stylopharyngeus muscle, inferior parathyroid gland, and thymus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Erbb2tm8(Erbb2)Mul/Erbb2+,Ptentm1Hwu/Ptentm1Hwu,Tg(MMTV-cre)7Mul/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Erbb2tm8(Erbb2)Mul/Erbb2+,Ptentm1Hwu/Ptentm1Hwu,Tg(MMTV-cre)7Mul/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Med12tm1.1Hsch/Med12tm1.1Hsch
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Erbb2tm8(Erbb2)Mul/Erbb2+,Ptentm1Hwu/Ptentm1Hwu,Tg(MMTV-cre)7Mul/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Med12tm1.1Hsch/Med12+,Tg(CMV-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Med12tm1.1Hsch/Med12+,Tg(CMV-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0011260 abnormal head mesenchyme morphology "any structural anomaly of the primordial embryonic connective tissue of the developing head, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to head connective tissue, bone and musculature in conjunction with cranial neural crest cells" [ISBN:0-683-40008-8]
Show

Allelic Composition: Erbb2tm8(Erbb2)Mul/Erbb2+,Ptentm1Hwu/Ptentm1Hwu,Tg(MMTV-cre)7Mul/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N

 MP:0011732 decreased somite size "reduced size of any of the segmental masses along the notochord of the developing embryo" [MGI:smb]
Show

Allelic Composition: Erbb2tm8(Erbb2)Mul/Erbb2+,Ptentm1Hwu/Ptentm1Hwu,Tg(MMTV-cre)7Mul/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N

 MP:0012159 absent anterior visceral endoderm "absence of the extraembryonic tissue that is responsible for the proper orientation of the anterior-posterior axis of the embryo and for appropriate patterning of adjacent embryonic tissue" [MGI:anna]
Show

Allelic Composition: Med12tm1.1Hsch/Med12tm1.1Hsch
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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