ENSG00000001630


Homo sapiens

Features
Gene ID: ENSG00000001630
  
Biological name :CYP51A1
  
Synonyms : CYP51A1 / cytochrome P450 family 51 subfamily A member 1 / Q16850
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: q21.2
Gene start: 92112151
Gene end: 92142952
  
Corresponding Affymetrix probe sets: 202314_at (Human Genome U133 Plus 2.0 Array)   216607_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000003100
Ensembl peptide - ENSP00000412536
Ensembl peptide - ENSP00000406757
Ensembl peptide - ENSP00000394268
NCBI entrez gene - 1595     See in Manteia.
OMIM - 601637
RefSeq - NM_001146152
RefSeq - NM_000786
RefSeq Peptide - NP_000777
RefSeq Peptide - NP_001139624
swissprot - Q16850
swissprot - A0A0C4DFL7
swissprot - H7C0D0
swissprot - C9IYR8
Ensembl - ENSG00000001630
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cyp51ENSDARG00000042641Danio rerio
 CYP51A1ENSGALG00000009365Gallus gallus
 Cyp51ENSMUSG00000001467Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O43174 / CYP26A1 / cytochrome P450 family 26 subfamily A member 1ENSG0000009559621
Q6V0L0 / CYP26C1 / cytochrome P450 family 26 subfamily C member 1ENSG0000018755321
Q9NR63 / CYP26B1 / cytochrome P450 family 26 subfamily B member 1ENSG0000000313720


Protein motifs (from Interpro)
Interpro ID Name
 IPR001128  Cytochrome P450
 IPR002403  Cytochrome P450, E-class, group IV
 IPR017972  Cytochrome P450, conserved site
 IPR036396  Cytochrome P450 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006694 steroid biosynthetic process IEA
 biological_processGO:0006695 cholesterol biosynthetic process TAS
 biological_processGO:0008202 steroid metabolic process IEA
 biological_processGO:0008203 cholesterol metabolic process IEA
 biological_processGO:0016125 sterol metabolic process TAS
 biological_processGO:0016126 sterol biosynthetic process IEA
 biological_processGO:0033488 cholesterol biosynthetic process via 24,25-dihydrolanosterol IBA
 biological_processGO:0045540 regulation of cholesterol biosynthetic process TAS
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0070988 demethylation IEA
 cellular_componentGO:0005783 endoplasmic reticulum IBA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031090 organelle membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0008398 sterol 14-demethylase activity TAS
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Cholesterol biosynthesis
Endogenous sterols
Activation of gene expression by SREBF (SREBP)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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