ENSG00000006712


Homo sapiens

Features
Gene ID: ENSG00000006712
  
Biological name :PAF1
  
Synonyms : PAF1 / PAF1 homolog, Paf1/RNA polymerase II complex component / Q8N7H5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: q13.2
Gene start: 39385852
Gene end: 39391195
  
Corresponding Affymetrix probe sets: 202093_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000221265
Ensembl peptide - ENSP00000469742
Ensembl peptide - ENSP00000468874
Ensembl peptide - ENSP00000396412
NCBI entrez gene - 54623     See in Manteia.
OMIM - 610506
RefSeq - NM_019088
RefSeq - NM_001256826
RefSeq Peptide - NP_001243755
RefSeq Peptide - NP_061961
swissprot - Q8N7H5
swissprot - A0A024R0H6
swissprot - M0QYC7
swissprot - B4DGJ5
Ensembl - ENSG00000006712
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 paf1ENSDARG00000098432Danio rerio
 PAF1ENSGALG00000037879Gallus gallus
 Paf1ENSMUSG00000003437Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007133  RNA polymerase II associated factor Paf1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISS
 biological_processGO:0001711 endodermal cell fate commitment ISS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II TAS
 biological_processGO:0006368 transcription elongation from RNA polymerase II promoter IEA
 biological_processGO:0006378 mRNA polyadenylation IMP
 biological_processGO:0010390 histone monoubiquitination IDA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0016567 protein ubiquitination TAS
 biological_processGO:0016570 histone modification IEA
 biological_processGO:0016584 nucleosome positioning IMP
 biological_processGO:0019827 stem cell population maintenance IEA
 biological_processGO:0031062 positive regulation of histone methylation IMP
 biological_processGO:0031442 positive regulation of mRNA 3"-end processing IMP
 biological_processGO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter IDA
 biological_processGO:0033523 histone H2B ubiquitination IDA
 biological_processGO:0034504 protein localization to nucleus IMP
 biological_processGO:0045638 negative regulation of myeloid cell differentiation IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0071222 cellular response to lipopolysaccharide ISS
 biological_processGO:1902808 positive regulation of cell cycle G1/S phase transition IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016593 Cdc73/Paf1 complex IEA
 cellular_componentGO:0030054 cell junction IDA
 molecular_functionGO:0000993 RNA polymerase II core binding IDA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Formation of RNA Pol II elongation complex
RNA Polymerase II Pre-transcription Events
RNA Polymerase II Transcription Elongation
E3 ubiquitin ligases ubiquitinate target proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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