ENSG00000008394


Homo sapiens

Features
Gene ID: ENSG00000008394
  
Biological name :MGST1
  
Synonyms : MGST1 / microsomal glutathione S-transferase 1 / P10620
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: p12.3
Gene start: 16347142
Gene end: 16609259
  
Corresponding Affymetrix probe sets: 1565162_s_at (Human Genome U133 Plus 2.0 Array)   224918_x_at (Human Genome U133 Plus 2.0 Array)   231736_x_at (Human Genome U133 Plus 2.0 Array)   239001_at (Human Genome U133 Plus 2.0 Array)   240688_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000442767
Ensembl peptide - ENSP00000442557
Ensembl peptide - ENSP00000442970
Ensembl peptide - ENSP00000010404
Ensembl peptide - ENSP00000379510
Ensembl peptide - ENSP00000379512
Ensembl peptide - ENSP00000379513
Ensembl peptide - ENSP00000437988
Ensembl peptide - ENSP00000438308
Ensembl peptide - ENSP00000440443
NCBI entrez gene - 4257     See in Manteia.
OMIM - 138330
RefSeq - XM_011520674
RefSeq - NM_001260511
RefSeq - NM_001260512
RefSeq - NM_001267598
RefSeq - NM_020300
RefSeq - NM_145764
RefSeq - NM_145791
RefSeq - NM_145792
RefSeq Peptide - NP_665707
RefSeq Peptide - NP_665734
RefSeq Peptide - NP_665735
RefSeq Peptide - NP_001247440
RefSeq Peptide - NP_001247441
RefSeq Peptide - NP_001254527
RefSeq Peptide - NP_064696
swissprot - F5GX73
swissprot - F5H613
swissprot - F5H6X2
swissprot - P10620
swissprot - A0A024RAX2
swissprot - F5H760
swissprot - F5H7F6
Ensembl - ENSG00000008394
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mgst1.1ENSDARG00000032618Danio rerio
 mgst1.2ENSDARG00000022165Danio rerio
 MGST1ENSGALG00000013098Gallus gallus
 Mgst1ENSMUSG00000008540Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PTGES / O14684 / prostaglandin E synthaseENSG0000014834437


Protein motifs (from Interpro)
Interpro ID Name
 IPR001129  Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein
 IPR023352  Membrane associated eicosanoid/glutathione metabolism-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006805 xenobiotic metabolic process TAS
 biological_processGO:0010243 response to organonitrogen compound IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0033327 Leydig cell differentiation IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0055114 oxidation-reduction process IDA
 biological_processGO:0070207 protein homotrimerization ISS
 biological_processGO:0071449 cellular response to lipid hydroperoxide IDA
 biological_processGO:0098869 cellular oxidant detoxification IEA
 biological_processGO:1901687 glutathione derivative biosynthetic process TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005741 mitochondrial outer membrane IEA
 cellular_componentGO:0005778 peroxisomal membrane ISS
 cellular_componentGO:0005783 endoplasmic reticulum ISS
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane ISS
 cellular_componentGO:0035577 azurophil granule membrane TAS
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0045177 apical part of cell IEA
 molecular_functionGO:0004364 glutathione transferase activity TAS
 molecular_functionGO:0004602 glutathione peroxidase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0043295 glutathione binding IEA


Pathways (from Reactome)
Pathway description
Glutathione conjugation
Aflatoxin activation and detoxification
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000008394 MGST1 / P10620 / microsomal glutathione S-transferase 1  / complex






 

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