ENSG00000014641


Homo sapiens

Features
Gene ID: ENSG00000014641
  
Biological name :MDH1
  
Synonyms : malate dehydrogenase 1 / MDH1 / P40925
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: p15
Gene start: 63588609
Gene end: 63607197
  
Corresponding Affymetrix probe sets: 200978_at (Human Genome U133 Plus 2.0 Array)   235374_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000386743
Ensembl peptide - ENSP00000394504
Ensembl peptide - ENSP00000446395
Ensembl peptide - ENSP00000438144
Ensembl peptide - ENSP00000410073
Ensembl peptide - ENSP00000409027
Ensembl peptide - ENSP00000400937
Ensembl peptide - ENSP00000399004
Ensembl peptide - ENSP00000233114
Ensembl peptide - ENSP00000386719
NCBI entrez gene - 4190     See in Manteia.
OMIM - 154200
RefSeq - NM_001316374
RefSeq - NM_005917
RefSeq - NM_001199111
RefSeq - NM_001199112
RefSeq Peptide - NP_001303303
RefSeq Peptide - NP_005908
RefSeq Peptide - NP_001186040
RefSeq Peptide - NP_001186041
swissprot - C9JRL4
swissprot - V9HWF2
swissprot - C9JLV6
swissprot - C9JF79
swissprot - C9IZI0
swissprot - B9A041
swissprot - B8ZZ51
swissprot - F8WFC2
swissprot - P40925
Ensembl - ENSG00000014641
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mdh1aaENSDARG00000017772Danio rerio
 mdh1abENSDARG00000103849Danio rerio
 MDH1ENSGALG00000008858Gallus gallus
 Mdh1ENSMUSG00000020321Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MDH1B / Q5I0G3 / malate dehydrogenase 1BENSG0000013840027


Protein motifs (from Interpro)
Interpro ID Name
 IPR001236  Lactate/malate dehydrogenase, N-terminal
 IPR001252  Malate dehydrogenase, active site
 IPR001557  L-lactate/malate dehydrogenase
 IPR010945  Malate dehydrogenase, type 2
 IPR011274  Malate dehydrogenase, NAD-dependent, cytosolic
 IPR015955  Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
 IPR022383  Lactate/malate dehydrogenase, C-terminal
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0006094 gluconeogenesis TAS
 biological_processGO:0006099 tricarboxylic acid cycle IBA
 biological_processGO:0006107 oxaloacetate metabolic process IBA
 biological_processGO:0006108 malate metabolic process IBA
 biological_processGO:0006734 NADH metabolic process IBA
 biological_processGO:0019674 NAD metabolic process IEA
 biological_processGO:0019752 carboxylic acid metabolic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005615 extracellular space HDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IBA
 cellular_componentGO:0005829 cytosol IBA
 cellular_componentGO:0043209 myelin sheath IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004470 malic enzyme activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016615 malate dehydrogenase activity IEA
 molecular_functionGO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
 molecular_functionGO:0030060 L-malate dehydrogenase activity TAS
 molecular_functionGO:0047860 diiodophenylpyruvate reductase activity IEA
 molecular_functionGO:0051287 NAD binding IEA


Pathways (from Reactome)
Pathway description
Gluconeogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000014641 MDH1 / P40925 / malate dehydrogenase 1  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr