ENSMUSG00000020321


Mus musculus

Features
Gene ID: ENSMUSG00000020321
  
Biological name :Mdh1
  
Synonyms : Malate dehydrogenase, cytoplasmic / Mdh1 / P14152
  
Possible biological names infered from orthology : malate dehydrogenase 1 / P40925
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: A3.1
Gene start: 21556787
Gene end: 21572367
  
Corresponding Affymetrix probe sets: 10384603 (MoGene1.0st)   1434319_at (Mouse Genome 430 2.0 Array)   1436834_x_at (Mouse Genome 430 2.0 Array)   1438338_at (Mouse Genome 430 2.0 Array)   1448172_at (Mouse Genome 430 2.0 Array)   1454925_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099938
Ensembl peptide - ENSMUSP00000119816
NCBI entrez gene - 17449     See in Manteia.
MGI - MGI:97051
RefSeq - NM_001316675
RefSeq - NM_008618
RefSeq Peptide - NP_001303604
RefSeq Peptide - NP_032644
swissprot - P14152
swissprot - B1ATQ3
Ensembl - ENSMUSG00000020321
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mdh1aaENSDARG00000017772Danio rerio
 mdh1abENSDARG00000103849Danio rerio
 MDH1ENSGALG00000008858Gallus gallus
 MDH1ENSG00000014641Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mdh1b / Q5F204 / Putative malate dehydrogenase 1B / Q5I0G3* / malate dehydrogenase 1B*ENSMUSG0000002596329


Protein motifs (from Interpro)
Interpro ID Name
 IPR001236  Lactate/malate dehydrogenase, N-terminal
 IPR001252  Malate dehydrogenase, active site
 IPR001557  L-lactate/malate dehydrogenase
 IPR010945  Malate dehydrogenase, type 2
 IPR011274  Malate dehydrogenase, NAD-dependent, cytosolic
 IPR015955  Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
 IPR022383  Lactate/malate dehydrogenase, C-terminal
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0006099 tricarboxylic acid cycle IBA
 biological_processGO:0006107 oxaloacetate metabolic process IEA
 biological_processGO:0006108 malate metabolic process IEA
 biological_processGO:0006734 NADH metabolic process IEA
 biological_processGO:0019674 NAD metabolic process IEA
 biological_processGO:0019752 carboxylic acid metabolic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005829 cytosol IBA
 cellular_componentGO:0043209 myelin sheath IDA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016615 malate dehydrogenase activity IEA
 molecular_functionGO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
 molecular_functionGO:0030060 L-malate dehydrogenase activity IBA
 molecular_functionGO:0051287 NAD binding IEA


Pathways (from Reactome)
Pathway description
Gluconeogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020321 Mdh1 / P14152 / Malate dehydrogenase, cytoplasmic / P40925* / malate dehydrogenase 1*  / complex






 

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