ENSG00000015413


Homo sapiens

Features
Gene ID: ENSG00000015413
  
Biological name :DPEP1
  
Synonyms : dipeptidase 1 / DPEP1 / P16444
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: 1
Band: q24.3
Gene start: 89613308
Gene end: 89638456
  
Corresponding Affymetrix probe sets: 205983_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000261615
Ensembl peptide - ENSP00000397313
Ensembl peptide - ENSP00000455142
Ensembl peptide - ENSP00000455916
Ensembl peptide - ENSP00000376807
NCBI entrez gene - 1800     See in Manteia.
OMIM - 179780
RefSeq - XM_017023009
RefSeq - NM_001128141
RefSeq - NM_004413
RefSeq - XM_005256285
RefSeq - XM_005256286
RefSeq - XM_011522925
RefSeq Peptide - NP_004404
RefSeq Peptide - NP_001121613
swissprot - H3BP43
swissprot - H3BQS5
swissprot - P16444
swissprot - A0A140VJI3
Ensembl - ENSG00000015413
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dpep1ENSDARG00000068181Danio rerio
 DPEP1ENSGALG00000006175Gallus gallus
 Dpep1ENSMUSG00000019278Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DPEP2 / Q9H4A9 / dipeptidase 2ENSG0000016726145
DPEP3 / Q9H4B8 / dipeptidase 3ENSG0000014109644


Protein motifs (from Interpro)
Interpro ID Name
 IPR000180  Membrane dipeptidase, active site
 IPR008257  Peptidase M19
 IPR028536  Dipeptidase 1
 IPR032466  Metal-dependent hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006691 leukotriene metabolic process TAS
 biological_processGO:0006749 glutathione metabolic process TAS
 biological_processGO:0006805 xenobiotic metabolic process TAS
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0016999 antibiotic metabolic process IDA
 biological_processGO:0030336 negative regulation of cell migration IMP
 biological_processGO:0035690 cellular response to drug IDA
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
 biological_processGO:0050667 homocysteine metabolic process IDA
 biological_processGO:0071277 cellular response to calcium ion ISS
 biological_processGO:0071732 cellular response to nitric oxide ISS
 biological_processGO:0072340 cellular lactam catabolic process TAS
 cellular_componentGO:0005615 extracellular space ISS
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0030054 cell junction IDA
 cellular_componentGO:0031225 anchored component of membrane IEA
 cellular_componentGO:0031528 microvillus membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0045177 apical part of cell IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008235 metalloexopeptidase activity TAS
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008239 dipeptidyl-peptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IDA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016805 dipeptidase activity TAS
 molecular_functionGO:0034235 GPI anchor binding ISS
 molecular_functionGO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process IMP
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070573 metallodipeptidase activity IDA
 molecular_functionGO:0072341 modified amino acid binding IDA


Pathways (from Reactome)
Pathway description
Synthesis of Leukotrienes (LT) and Eoxins (EX)
Aflatoxin activation and detoxification


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000015413 DPEP1 / P16444 / dipeptidase 1  / complex






 

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