ENSG00000035928


Homo sapiens

Features
Gene ID: ENSG00000035928
  
Biological name :RFC1
  
Synonyms : P35251 / replication factor C subunit 1 / RFC1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: -1
Band: p14
Gene start: 39287456
Gene end: 39366375
  
Corresponding Affymetrix probe sets: 208021_s_at (Human Genome U133 Plus 2.0 Array)   209085_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000422129
Ensembl peptide - ENSP00000422475
Ensembl peptide - ENSP00000491208
Ensembl peptide - ENSP00000424713
Ensembl peptide - ENSP00000422740
Ensembl peptide - ENSP00000261424
Ensembl peptide - ENSP00000371321
NCBI entrez gene - 5981     See in Manteia.
OMIM - 102579
RefSeq - XM_017008528
RefSeq - NM_001204747
RefSeq - NM_002913
RefSeq - XM_011513730
RefSeq - XM_011513731
RefSeq Peptide - NP_001191676
RefSeq Peptide - NP_002904
swissprot - D6RAD2
swissprot - A0A1W2PP02
swissprot - H0Y8U4
swissprot - P35251
swissprot - H0Y9P8
swissprot - E0CX09
Ensembl - ENSG00000035928
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rfc1ENSDARG00000054799Danio rerio
 RFC1ENSGALG00000014298Gallus gallus
 Rfc1ENSMUSG00000029191Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001357  BRCT domain
 IPR003593  AAA+ ATPase domain
 IPR003959  ATPase, AAA-type, core
 IPR008921  DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal
 IPR012178  Replication factor C subunit 1
 IPR013725  DNA replication factor RFC1, C-terminal
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR036420  BRCT domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006261 DNA-dependent DNA replication TAS
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006283 transcription-coupled nucleotide-excision repair TAS
 biological_processGO:0006296 nucleotide-excision repair, DNA incision, 5"-to lesion TAS
 biological_processGO:0006297 nucleotide-excision repair, DNA gap filling TAS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007004 telomere maintenance via telomerase TAS
 biological_processGO:0019985 translesion synthesis TAS
 biological_processGO:0032201 telomere maintenance via semi-conservative replication TAS
 biological_processGO:0033683 nucleotide-excision repair, DNA incision TAS
 biological_processGO:0042276 error-prone translesion synthesis TAS
 biological_processGO:0042769 DNA damage response, detection of DNA damage TAS
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0070987 error-free translesion synthesis TAS
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005663 DNA replication factor C complex IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding IBA
 molecular_functionGO:0003689 DNA clamp loader activity IEA
 molecular_functionGO:0003690 double-stranded DNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008047 enzyme activator activity TAS
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
Translesion synthesis by REV1
Recognition of DNA damage by PCNA-containing replication complex
Translesion Synthesis by POLH
Polymerase switching on the C-strand of the telomere
PCNA-Dependent Long Patch Base Excision Repair
Translesion synthesis by POLK
Translesion synthesis by POLI
Termination of translesion DNA synthesis
HDR through Homologous Recombination (HRR)
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Polymerase switching


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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