ENSG00000052344


Homo sapiens

Features
Gene ID: ENSG00000052344
  
Biological name :PRSS8
  
Synonyms : PRSS8 / Q16651 / serine protease 8
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: -1
Band: p11.2
Gene start: 31131433
Gene end: 31135762
  
Corresponding Affymetrix probe sets: 202525_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000457750
Ensembl peptide - ENSP00000458056
Ensembl peptide - ENSP00000319730
Ensembl peptide - ENSP00000457673
NCBI entrez gene - 5652     See in Manteia.
OMIM - 600823
RefSeq - NM_002773
RefSeq Peptide - NP_002764
swissprot - H3BUJ8
swissprot - H3BVC8
swissprot - Q16651
Ensembl - ENSG00000052344
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CU571315.2ENSDARG00000101956Danio rerio
 CU571315.3ENSDARG00000101990Danio rerio
 prss60.1ENSDARG00000070713Danio rerio
 prss60.2ENSDARG00000055644Danio rerio
 prss60.3ENSDARG00000070710Danio rerio
 si:ch73-182e20.4ENSDARG00000102727Danio rerio
 si:dkey-16l2.17ENSDARG00000027196Danio rerio
 si:dkey-32n7.7ENSDARG00000063444Danio rerio
 si:dkey-32n7.9ENSDARG00000071841Danio rerio
 si:dkeyp-93a5.2ENSDARG00000052064Danio rerio
 si:dkeyp-93a5.2ENSDARG00000100953Danio rerio
 si:dkeyp-93a5.3ENSDARG00000096975Danio rerio
 zgc:100868ENSDARG00000004748Danio rerio
 zgc:112038ENSDARG00000046140Danio rerio
 zgc:123217ENSDARG00000059026Danio rerio
 zgc:123295ENSDARG00000056324Danio rerio
 zgc:153968ENSDARG00000061858Danio rerio
 zgc:163079ENSDARG00000056773Danio rerio
 zgc:165423ENSDARG00000052905Danio rerio
 zgc:92313ENSDARG00000040513Danio rerio
 Prss8ENSMUSG00000030800Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TPSG1 / Q9NRR2 / tryptase gamma 1ENSG0000011617637
PRSS33 / Q8NF86 / serine protease 33ENSG0000010335537
PRSS21 / Q9Y6M0 / serine protease 21ENSG0000000703836
PRSS22 / Q9GZN4 / serine protease 22ENSG0000000500136
PRSS27 / Q9BQR3 / serine protease 27ENSG0000017238234
PRSS41 / Q7RTY9 / serine protease 41ENSG0000021514833
PRSS48 / Q7RTY5 / serine protease 48ENSG0000018909933
A1L453 / PRSS38 / serine protease 38ENSG0000018588831
PRSS42 / Q7Z5A4 / serine protease 42ENSG0000017805527
PRSS45 / Q7RTY3 / serine protease 45ENSG0000018808624
AC109583.3ENSG0000028467212


Protein motifs (from Interpro)
Interpro ID Name
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR009003  Peptidase S1, PA clan
 IPR018114  Serine proteases, trypsin family, histidine active site
 IPR033116  Serine proteases, trypsin family, serine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0010765 positive regulation of sodium ion transport IBA
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0070268 cornification TAS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0019897 extrinsic component of plasma membrane IBA
 cellular_componentGO:0046658 anchored component of plasma membrane IBA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004175 endopeptidase activity TAS
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity TAS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0017080 sodium channel regulator activity IBA


Pathways (from Reactome)
Pathway description
Formation of the cornified envelope


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000052344 PRSS8 / Q16651 / serine protease 8  / complex
 ENSG00000143631 FLG / P20930 / filaggrin  / reaction






 

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